A5003861240- Plant Molecular Biology Research
- Plant Reproductive Biology
- Plant nutrient uptake and metabolism
- Plant Stress Responses and Tolerance
- Plant Gene Expression Analysis
- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- Photosynthetic Processes and Mechanisms
- Plant Virus Research Studies
- Chromatin Remodeling and Cancer
- Plant biochemistry and biosynthesis
- Plant tissue culture and regeneration
- Plant Genetic and Mutation Studies
- Esophageal Cancer Research and Treatment
- Immune Cell Function and Interaction
- Seed and Plant Biochemistry
- Polysaccharides and Plant Cell Walls
- Direction-of-Arrival Estimation Techniques
- Light effects on plants
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- RNA Research and Splicing
- Genetics and Plant Breeding
- Sparse and Compressive Sensing Techniques
- Healthcare and Venom Research
Ajou University
2025
Nagoya University
2018-2024
Seattle University
2017-2023
Virginia Mason Medical Center
2023
University of Pennsylvania
2012-2021
Daegu Gyeongbuk Institute of Science and Technology
2021
Howard Hughes Medical Institute
2016-2018
University of Washington
1968-2018
Gyeongsang National University
2006-2018
Sogang University
2003-2017
Abstract The transcriptional coactivator ANGUSTIFOLIA3 (AN3) stimulates cell proliferation during Arabidopsis thaliana leaf development, but the molecular mechanism is largely unknown. Here, we show that inducible nuclear localization of AN3 initial growth results in differential expression important regulators, including GROWTH REGULATING FACTORs (GRFs). Chromatin purification further revealed presence at loci GRF5, GRF6, CYTOKININ RESPONSE FACTOR2, CONSTANS-LIKE5 (COL5), HECATE1 (HEC1),...
Abstract We analyzed 6,749 lines tagged by the gene trap vector pGA2707. This resulted in isolation of 3,793 genomic sequences flanking T-DNA. Among insertions, 1,846 T-DNAs were integrated into genic regions, and 1,864 located intergenic regions. Frequencies also higher at beginning end coding regions upstream near ATG start codon. The overall GC content insertion sites was close to that measured from entire rice (Oryza sativa) genome. Functional classification these genes showed a...
Patterning of the floral organs is exquisitely controlled and executed by four classes homeotic regulators. Among these, class B C regulators are central importance as they specify male female reproductive organs. Inappropriate induction gene APETALA3 ( AP3 ) AGAMOUS AG causes reduced fitness prevented polycomb repression. At onset flower patterning, repression needs to be overcome allow formation We show that SWI2/SNF2 chromatin-remodeling ATPases SPLAYED (SYD) BRAHMA (BRM) redundantly...
Abstract The survival of plants as sessile organisms depends on their ability to cope with environmental challenges. Of key importance in this regard is the phytohormone abscisic acid (ABA). ABA not only promotes seed dormancy but also triggers growth arrest postgermination embryos that encounter water stress. This accompanied by increased desiccation tolerance. Postgermination responses Arabidopsis thaliana are mediated large part ABA-induced basic domain/leucine zipper transcription factor...
Summary To cope with a lifetime of exposure to variety pathogens, plants have developed exquisite and refined defense mechanisms that vary depending on the type attacking pathogen. Defense‐associated transcriptional reprogramming is central part plant mechanisms. Chromatin modification has recently been shown be another layer regulation for Here, we show RPD3/HDA1‐class histone deacetylase HDA19 involved in repression salicylic acid (SA)‐mediated responses Arabidopsis. Loss activity...
Abstract Master transcription factors reprogram cell fate in multicellular eukaryotes. Pioneer have prominent roles this process because of their ability to contact cognate binding motifs closed chromatin. Reprogramming is pervasive plants, whose development plastic and tuned by the environment, yet little known about pioneer kingdom. Here, we show that master factor LEAFY (LFY), which promotes floral through upregulation commitment APETALA1 ( AP1 ), a factor. In vitro, LFY binds endogenous...
Differentiation of specialized cell types requires precise cell-cycle control. Plant stomata are generated through asymmetric divisions a stem-cell-like precursor followed by single symmetric division that creates paired guard cells surrounding pore. The stomatal-lineage-specific transcription factor MUTE terminates the and commits to differentiation. However, role machineries in this transition remains unknown. We discover is slower than Arabidopsis. identify plant-specific cyclin-dependent...
Development of stomata, valves on the plant epidermis for optimal gas exchange and water control, is fine-tuned by multiple signaling peptides with unique, overlapping, or antagonistic activities. EPIDERMAL PATTERNING FACTOR1 (EPF1) a founding member secreted peptide ligands enforcing stomatal patterning. Yet, its exact role remains unclear. Here, we report that EPF1 primary receptor ERECTA-LIKE1 (ERL1) target MUTE, transcription factor specifying proliferation-to-differentiation switch...
CREB-binding protein (CBP) and its homolog p300 possess histone acetyltransferase activity function as key transcriptional co-activators in the regulation of gene expression that controls differentiation development animals. However, role CBP/p300-like genes plants has not yet been elucidated. Here, we show Arabidopsis promote flowering by affecting a major floral repressor FLOWERING LOCUS C (FLC). Although animal CBP generally co-activators, proteins are required for negative FLC. This...
Abstract Chromatin architecture and transcription factor (TF) binding underpin cell-fate specification during development, but their mutual regulatory relationships remain unclear. Here we report an atlas of dynamic chromatin landscapes stomatal cell-lineage progression, in which sequential cell-state transitions are governed by lineage-specific bHLH TFs. Major reprogramming accessibility occurs at the proliferation-to-differentiation transition. We discover novel co- cis elements (CREs)...
Summary The mechanism of macrophage migration-inhibition was studied with alveolar macrophages obtained from BCG-sensitized guinea pigs. Sensitivity to conferred upon normal pigs or trypsinized sensitized by incubation either serum heat eluates prepared animals. migration passively inhibited only in the presence specific antigen. Mixtures PPD and immune were cytophilic for but not demonstrably cytotoxic mouse L cells. In contrast, supernatants cultures antigen-stimulated lymphocytes derived...
Selective perturbation of protein interactions with chemical compounds enables dissection and control developmental processes. Differentiation stomata, cellular valves vital for plant growth survival, is specified by the basic-helix-loop-helix (bHLH) heterodimers. Harnessing a new amination reaction, we here report synthesis, derivatization, target identification, mode action an atypical doubly-sulfonylated imidazolone, Stomidazolone, which triggers stomatal stem cell arrest. Our forward...
SUMMARY Precise cell division control is critical for developmental patterning. For the differentiation of a functional stoma, cellular valve efficient gas exchange, single symmetric an immediate precursor absolutely essential. Yet, mechanism governing event remains unclear. Here we report complete inventories gene expression by Arabidopsis bHLH protein MUTE, potent inducer stomatal differentiation. MUTE switches program initiated its sister bHLH, SPEECHLESS. directly induces suite...
Selective perturbation of protein interactions with chemical compounds enables dissection and control developmental processes. Differentiation stomata, cellular valves vital for plant growth survival, is specified by the basic-helix-loop-helix (bHLH) heterodimers. Harnessing a new amination reaction, we here report synthesis, derivatization, target identification, mode action an atypical doubly-sulfonylated imidazolone, Stomidazolone, which triggers stomatal stem cell arrest. Our forward...
ABSTRACT Master transcription factors reprogram cell fate in multicellular eukaryotes. Pioneer have prominent roles this process because of their ability to contact cognate binding motifs closed chromatin. Reprogramming is pervasive plants, whose development plastic and tuned by the environment, yet no bonafide pioneer factor has - been identified kingdom. Here we show that master LEAFY (LFY), which promotes floral through upregulation commitment APETALA1 ( AP1 ), a factor. In vitro, LFY...