Calvin M. Coffin

ORCID: 0009-0007-2154-791X
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About
Contact & Profiles
Research Areas
  • Plant tissue culture and regeneration
  • Plant Molecular Biology Research
  • Plant Virus Research Studies
  • Plant Gene Expression Analysis
  • Plant nutrient uptake and metabolism

Howard Hughes Medical Institute
2023-2024

The University of Texas at Austin
2023-2024

Selective perturbation of protein interactions with chemical compounds enables dissection and control developmental processes. Differentiation stomata, cellular valves vital for plant growth survival, is specified by the basic-helix-loop-helix (bHLH) heterodimers. Harnessing a new amination reaction, we here report synthesis, derivatization, target identification, mode action an atypical doubly-sulfonylated imidazolone, Stomidazolone, which triggers stomatal stem cell arrest. Our forward...

10.1038/s41467-024-53214-4 article EN cc-by Nature Communications 2024-10-23

Selective perturbation of protein interactions with chemical compounds enables dissection and control developmental processes. Differentiation stomata, cellular valves vital for plant growth survival, is specified by the basic-helix-loop-helix (bHLH) heterodimers. Harnessing a new amination reaction, we here report synthesis, derivatization, target identification, mode action an atypical doubly-sulfonylated imidazolone, Stomidazolone, which triggers stomatal stem cell arrest. Our forward...

10.1101/2023.11.02.565226 preprint EN cc-by bioRxiv (Cold Spring Harbor Laboratory) 2023-11-04
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