A5033953776- Plant Molecular Biology Research
- Plant Reproductive Biology
- Marine Invertebrate Physiology and Ecology
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Plant Gene Expression Analysis
- Photosynthetic Processes and Mechanisms
- Genomics and Chromatin Dynamics
- Planarian Biology and Electrostimulation
- Plant nutrient uptake and metabolism
- Marine Ecology and Invasive Species
- Cardiomyopathy and Myosin Studies
- Plant Genetic and Mutation Studies
- RNA and protein synthesis mechanisms
- Protist diversity and phylogeny
Pfizer (United States)
2024-2025
National Human Genome Research Institute
2023-2024
National Institutes of Health
2023
University of Pennsylvania
2017-2022
Abstract Plants monitor seasonal cues to optimize reproductive success by tuning onset of reproduction and inflorescence architecture. TERMINAL FLOWER 1 (TFL1) FLOWERING LOCUS T (FT) their orthologs antagonistically regulate these life history traits, yet mechanism action, antagonism targets remain poorly understood. Here, we show that TFL1 is recruited thousands loci the bZIP transcription factor FD. We identify master regulator floral fate, LEAFY ( LFY ) as a target under dual opposite...
Abstract Master transcription factors reprogram cell fate in multicellular eukaryotes. Pioneer have prominent roles this process because of their ability to contact cognate binding motifs closed chromatin. Reprogramming is pervasive plants, whose development plastic and tuned by the environment, yet little known about pioneer kingdom. Here, we show that master factor LEAFY (LFY), which promotes floral through upregulation commitment APETALA1 ( AP1 ), a factor. In vitro, LFY binds endogenous...
Hydractinia is a colonial marine hydroid that shows remarkable biological properties, including the capacity to regenerate its entire body throughout lifetime, process made possible by adult migratory stem cells, known as i-cells. Here, we provide an in-depth characterization of genomic structure and gene content two species, symbiolongicarpus echinata , placing them in comparative evolutionary framework with other cnidarian genomes. We also generated annotated single-cell transcriptomic...
Cardiomyopathy presents a significant medical burden due to frequent hospitalizations and invasive interventions. While cardiomyopathy is considered rare monogenic disorder caused by pathogenic variants in few genes, emerging evidence suggests that common genetic modifiers influence disease penetrance clinical variability. Quantifying the interplay between challenging rarity of cases variant carriers. In this study, we utilized large-scale phenotypic data from UK Biobank refine architecture...
Abstract Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is widely used to identify factor binding genomic DNA and chromatin modifications. ChIP-seq data analysis affected regions that generate ultra-high artifactual signals. To remove these signals from data, the Encyclopedia of Elements (ENCODE) project developed comprehensive sets defined low mappability called blacklists for human, mouse (Mus musculus), nematode (Caenorhabditis elegans), fruit fly (Drosophila...
ABSTRACT Hydractinia is a colonial marine hydroid that exhibits remarkable biological properties, including the capacity to regenerate its entire body throughout lifetime, process made possible by adult migratory stem cells, known as i-cells. Here, we provide an in-depth characterization of genomic structure and gene content two species, H. symbiolongicarpus echinata , placing them in comparative evolutionary framework with other cnidarian genomes. We also generated annotated single-cell...
ABSTRACT Master transcription factors reprogram cell fate in multicellular eukaryotes. Pioneer have prominent roles this process because of their ability to contact cognate binding motifs closed chromatin. Reprogramming is pervasive plants, whose development plastic and tuned by the environment, yet no bonafide pioneer factor has - been identified kingdom. Here we show that master LEAFY (LFY), which promotes floral through upregulation commitment APETALA1 ( AP1 ), a factor. In vitro, LFY...
Cardiomyopathy presents significant medical burden due to frequent hospitalizations and invasive interventions. While cardiomyopathy is considered a rare monogenic disorder caused by pathogenic variants in few genes, emerging evidence suggests that common genetic modifiers influence disease penetrance clinical variability. Quantifying the interplay between challenging rarity of cases variant carriers. In this study, we utilized large-scale phenotypic data from UK Biobank refine architecture...
Abstract Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is used widely to identify both factor binding genomic DNA and chromatin modifications. Analysis of ChIP-seq data impacted regions the genome which generate ultra-high artifactual signals. To remove these signals from data, ENCODE developed blacklists, comprehensive sets defined low mappability for human, mouse, worm, flies. Currently, blacklists are not available many model non-model species. Here we describe an...
Abstract Plants monitor seasonal cues, such as day-length, to optimize life history traits including onset of reproduction and inflorescence architecture 1–3 . Florigen family transcriptional co-regulators TERMINAL FLOWER 1 (TFL1) FLOWERING LOCUS T (FT) antagonistically regulate these vital processes 4–6 yet how TFL1 FT execute their roles what the mechanism is for antagonism remains poorly understood. We show genome-wide, that recruited chromatin by bZIP transcription factor D (FD) in...