A5049327895- Autophagy in Disease and Therapy
- Mycobacterium research and diagnosis
- Gut microbiota and health
- Calcium signaling and nucleotide metabolism
- Adenosine and Purinergic Signaling
- Inflammasome and immune disorders
- Dietary Effects on Health
- Tuberculosis Research and Epidemiology
- Mast cells and histamine
- Spine and Intervertebral Disc Pathology
- Cancer, Hypoxia, and Metabolism
- COVID-19 Clinical Research Studies
- Quinazolinone synthesis and applications
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Pain Mechanisms and Treatments
- Retinoids in leukemia and cellular processes
- Pneumocystis jirovecii pneumonia detection and treatment
- Electron Spin Resonance Studies
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Asthma and respiratory diseases
- Heme Oxygenase-1 and Carbon Monoxide
Chungnam National University
2012-2025
University of Pittsburgh
2022-2024
University of Pittsburgh Medical Center
2024
University of Manitoba
2023
Korea Basic Science Institute
2022
Gyeongsang National University
2022
Weatherford College
2022
Keimyung University
2022
Observational studies of the ongoing coronavirus disease 2019 (COVID-19) outbreak suggest that a 'cytokine storm' is involved in pathogenesis severe illness. However, molecular mechanisms underlying altered pathological inflammation COVID-19 are largely unknown. We report here toll-like receptor (TLR) 4-mediated inflammatory signaling molecules upregulated peripheral blood mononuclear cells (PBMCs) from patients, compared with healthy controls (HC).
Nontuberculous mycobacterial pulmonary diseases (NTM-PDs) are emerging as global health threats with issues of antibiotic resistance. Accumulating evidence suggests that the gut–lung axis may provide novel candidates for host-directed therapeutics against various infectious diseases. However, little is known about in context host protective immunity to identify new NTM-PDs. This study was performed gut microbes and metabolites capable conferring Using metabolomics analysis sera from NTM-PD...
The orphan nuclear receptor ESRRA (estrogen related alpha) is critical in mitochondrial biogenesis and macroautophagy/autophagy function; however, the roles of intestinal function remain uncharacterized. Herein we identified that acts as a key regulator homeostasis by amelioration colonic inflammation through activation autophagic flux control host gut microbiota. Esrra-deficient mice presented with increased susceptibility to dextran sodium sulfate (DSS)-induced colitis upregulation...
Low back pain is a global health problem that originated mainly from intervertebral disc degeneration (IDD). Autophagy, negatively regulated by the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway, prevents metabolic and degenerative diseases removing recycling damaged cellular components. Despite growing evidence autophagy occurs in disc, regulation still poorly understood.
Itaconate, a crucial immunometabolite, plays critical role in linking immune and metabolic functions to influence host defense inflammation. Due its polar structure, the esterified cell-permeable derivatives of itaconate are being developed provide therapeutic opportunities infectious inflammatory diseases. Yet, it remains largely uncharacterized whether have potentials promoting host-directed therapeutics (HDT) against mycobacterial infections. Here, we report dimethyl (DMI) as promising...
Abstract Infection with rapidly growing nontuberculous mycobacteria is emerging as a global health issue; however, key host factors remain elusive. Here, we investigated the characteristic immune profiles of peripheral blood mononuclear cells (PBMCs) from patients infected Mycobacteroides abscessus subsp . (Mabc) and M. subsp. massiliense (Mmass). Using an integrated analysis mRNA microRNA expression profiles, found that several inflammatory cytokines/chemokines [interleukin (IL)-1β, IL-6 ,...
Abstract Background The gut microbiota plays a pivotal role in maintaining intestinal homeostasis and mitigating inflammation. orphan nuclear receptor ESRRA (estrogen-related alpha) has been identified as critical regulator of mitochondrial function autophagy, yet its modulation health remains unclear. Methods We investigated using Esrra-deficient mice dextran sodium sulfate (DSS)-induced colitis model. Colitis severity is through survival rate body weight. Gut barrier was evaluated...
Abstract Mitochondrial function and innate immunity are intimately linked; however, the mechanisms how mitochondrion-shaping proteins regulate host defense remains largely unknown. Herein we show that mitofusin-2 (MFN2), a mitochondrial fusion protein, promotes through maintenance of aerobic glycolysis xenophagy via hypoxia-inducible factor (HIF)-1α during intracellular bacterial infection. Myeloid-specific MFN2 deficiency in mice impaired antimicrobial inflammatory responses against...