A5100410195- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Meat and Animal Product Quality
- Animal Nutrition and Physiology
- Effects of Environmental Stressors on Livestock
- Molecular Biology Techniques and Applications
- Genetic diversity and population structure
- Animal Genetics and Reproduction
- Food Quality and Safety Studies
- Diverse Approaches in Healthcare and Education Studies
- Livestock and Poultry Management
- Nutrition, Health and Food Behavior
- Diverse Topics in Contemporary Research
- melanin and skin pigmentation
- Immune Cell Function and Interaction
- Peroxisome Proliferator-Activated Receptors
- Identification and Quantification in Food
- Gene expression and cancer classification
- Agriculture, Soil, Plant Science
- Biochemical Analysis and Sensing Techniques
- Animal Behavior and Welfare Studies
- Bioinformatics and Genomic Networks
- Forensic and Genetic Research
- Reproductive Physiology in Livestock
Chungnam National University
2016-2025
Korea Basic Science Institute
2017-2025
Sungkyunkwan University
2025
Catholic University of Korea
2021-2023
Seoul St. Mary's Hospital
2021-2023
Gyeongsang National University
2015-2023
National Institute of Fisheries Science
2023
International Vaccine Institute
2023
University of Ottawa
2001-2022
McMaster University
2022
Changes in the expression levels of avian β-defensin (AvBD) mRNA were evaluated necrotic enteritis (NE) disease model 2 genetically disparate commercial broiler chicken lines: Ross and Cobb. The NE was initiated gut by a previously established co-infection using oral Eimeria maxima infection followed Clostridium perfringens challenge. Among 14 AvBD types examined, there tissue-specific transcripts: AvBD1, AvBD7, AvBD9 crop; AvBD8, AvBD10, AvBD13; intestine AvBD1 AvBD7 spleen. different lines...
Abstract Cmv1 was the first mouse cytomegalovirus (MCMV) resistance locus identified in C57BL/6 mice. It encodes Ly49H, a NK cell-activating receptor that specifically recognizes m157 viral protein at surface of MCMV-infected cells. To dissect effect Ly49h gene host-pathogen interactions, we generated mice lacking region. We found 36 h after MCMV infection, lack resulted high replication spleen and dramatically enhanced proinflammatory cytokine production serum spleen. At later points time,...
This genome-wide association study (GWAS) was conducted to identify major loci that are significantly associated with carcass weight, and their effects, in order provide increased understanding of the genetic architecture weight Hanwoo. identified one chromosome region ranging from 23 Mb 25 on 14 as being Significant Bonferroni-corrected associations (P<1.52×10−6) were detected for 6 Single Nucleotide Polymorphic (SNP) 14. The most significant SNP BTB-01280026 (P = 4.02×10−11), located Bos...
Face morphology is strongly determined by genetic factors. However, only a small number of genes related to face have been identified date. Here, we performed two-stage genome-wide association study (GWAS) 85 morphological traits in 7569 Koreans (5643 the discovery set and 1926 replication set). In this study, analyzed facial traits, including angles. After GWAS, 128 single nucleotide polymorphisms (SNPs) showing an P < 5 × 10− 6 were selected determine associations, meta-analysis GWAS...
MicroRNAs (miRNA) are a class of small (∼22 nucleotides) noncoding RNAs that regulate diverse biological processes at the post‐transcriptional level. MiRNAs have great potential for forensic body fluid identification because they expressed in tissue specific manner and less prone to degradation. Previous studies reported several miRNAs as specific, but there few overlaps among them. Here, we used genome‐wide miRNA microarray containing over 1700 assay 20 samples identify novel useful...
Non-synonymous SNPs and protein coding within the promoter region of genes (regulatory SNPs) might have a significant effect on carcass traits. Imputed sequence level data 10,215 Hanwoo bulls, annotated filtered to include only regulatory (450,062 SNPs), were used in genome-wide association study (GWAS) identify loci associated with backfat thickness (BFT), weight (CWT), eye muscle area (EMA), marbling score (MS). A total 15, 176, 1 found be significantly (p < 1.11 × 10−7) BFT, CWT, EMA,...
Synthetic double-stranded RNA analogs recognized by Toll-like receptor 3 (TLR3) are an attractive adjuvant candidate for vaccines, especially against intracellular pathogens or tumors, because of their ability to enhance T cell and antibody responses. Although poly(I:C) is a representative dsRNA with potent adjuvanticity, its clinical application has been limited due heterogeneous molecular size, inconsistent activity, poor stability, toxicity. To overcome these limitations, we developed...
Natural resistance to infection with mouse cytomegalovirus (MCMV) is controlled by a dominant locus, Cmv1. Cmv1 linked the Ly49 family of natural killer receptors on distal chromosome 6. While some studies localized as gene cluster, genetic and functional analysis identified Ly49h pivotal factor in MCMV. The role these two independent genomic domains MCMV was evaluated complementation using transgenesis bacterial artificial chromosomes (BAC) genetically susceptible mice. Phenotypic...
The protective effect of hyperimmune IgY fraction egg yolk prepared from hens hyperimmunized with multiple species Eimeria oocysts on experimental coccidiosis was evaluated in young broilers. Chickens were continuously fed hatch a standard diet containing powder or nonsupplemented control and orally challenged at d 7 posthatch 5.0 × 103 sporulated acervulina oocysts. Body weight gain between 0 10 fecal oocyst shedding 5 postinfection determined as parameters immunity. given 20% showed...
Among dietary phytonutrients, carvacrol, cinnamaldehyde, and Capsicum oleoresin are well known for their antiinflammatory antibiotic effects in human veterinary medicine. To further define the molecular genetic mechanisms responsible these properties, broiler chickens were fed a standard diet supplemented with either of 3 phytochemicals intestinal intraepithelial lymphocytes examined changes gene expression by microarray analysis. When compared nonsupplemented diet, carvacrol-fed showed...
Hanwoo (Korean cattle), which originated from natural crossbreeding between taurine and zebu cattle, migrated to the Korean peninsula through North China. were raised as draft animals until 1970s without introduction of foreign germplasm. Since 1979, has been bred beef cattle. Genetic variation was analyzed by whole-genome deep resequencing a bull. The genome compared that two other breeds, Black Angus Holstein, genes within regions homozygosity investigated elucidate genetic genomic...