A5049662665- Cancer and Skin Lesions
- Genetic and rare skin diseases.
- Dermatology and Skin Diseases
- Advancements in Transdermal Drug Delivery
- Nail Diseases and Treatments
- Skin Protection and Aging
- Neurofibromatosis and Schwannoma Cases
- Contact Dermatitis and Allergies
- melanin and skin pigmentation
- Dermatological and Skeletal Disorders
- Tumors and Oncological Cases
- Nonmelanoma Skin Cancer Studies
- Dermatologic Treatments and Research
- Skin and Cellular Biology Research
- Vascular Malformations and Hemangiomas
- Skin Diseases and Diabetes
- Hedgehog Signaling Pathway Studies
- Psoriasis: Treatment and Pathogenesis
- Autoimmune Bullous Skin Diseases
- Healthcare and Venom Research
- Acne and Rosacea Treatments and Effects
- Hair Growth and Disorders
- Soft tissue tumor case studies
- Dermatological and COVID-19 studies
- Cutaneous Melanoma Detection and Management
Yonsei University
2013-2023
Wonju Severance Christian Hospital
2017-2019
Samsung (United States)
2019
University of Ulsan
2008
University of California, San Francisco
2002
Avon (United States)
2001
Ursolic acid (UA) and oleanolic (ONA) are pentacyclic triterpenoids, which naturally occur in many medicinal herbs plants. Recent research revealed that several pharmacological effects could be attributed to UA ONA, such as anti-tumor, anti-inflammatory anti-microbial activities. To evaluate the of ONA on epidermal permeability barrier recovery normal skin, both flanks hairless mice were topically treated with either 0.01-0.1 mg/mL or 0.1-1.0 after tape stripping transepidermal water loss...
Abstract Background There has been little research on extramammary Paget’s disease (EMPD) conducted in Asia. Methods The aim of this multicenter study was to investigate the clinicopathological features, biological behavior, and treatment EMPD 194 Korean patients over a five‐year period. Results As expected, exhibited male dominance (3.9:1) pattern. To distinguish true association malignancy with from coincidental occurrence malignancy, we modified Chanda’s guidelines. This analysis...
Summary Background Even with the widespread clinical use of cannabinoid receptor ( CBR ) stimulating compounds, such as palmitoylethanolamine, role agonists on inflammatory skin diseases is not yet fully understood. This study was performed to investigate effects inflammation, using acute and chronic inflammation animal models. Methods The effectiveness newly synthesized 1 CB 1R) determined in vitro assays. Markers for epidermal permeability barrier function were measured, histological...
Reportedly, decreases in fatty acid (FA) chain length of ceramide (CER) are associated with interferon-γ (IFN-γ), which shows increased expression psoriasis. However, the underlying mechanism this association remains unclear. Therefore, study, we aimed to clarify between FA CER, IFN-γ, and major transcriptional factors involving CER profiling according class was performed murine epidermis (n = 10 BALB/c mice topically treated imiquimod, n controls) human stratum corneum (SC) 12 psoriasis, 11...
The transdermal drug delivery (TDD) system has largely been divided into physical, biochemical and chemical methods. Recently, combinations of these methods were introduced for more effective with less side effects. We performed this study to identify the effectiveness mechanism TDD using physical method, 'iontophoresis', plus 'pretreatment enhancer'. action sites enhancers in stratum corneum (SC) observed by electron microscope. also studied whether combined method synergistically impaired...
An analysis of Nimbus 7 solar backscattered ultraviolet (SBUV) monthly average total ozone data for changes over the 7‐year period from November 1978 through September 1985 is considered. Regression‐time series models, which include seasonal components, a linear trend term, an F 10.7 flux and autocorrelated autoregressive noise term to account variations in ozone, are estimated both latitudinal zonal averages global this time period. The resulting coefficient estimates examined. A comparison...
Acupuncture and cupping have a public reputation as being safe even though these practices can lead to complications such trauma or infection.We report here on case of herpes simplex virus (HSV) infection secondary acupuncture in 56-year-old woman.The patient, who had history her left forearm for treating myalgia, developed painful papules.Histologically, the biopsy specimen showed characteristic ballooning degeneration inclusion bodies epidermis mid-dermis.These clinical histological...
Psoriasis is an immune-mediated, chronic inflammatory disease affecting multiple aspects of patients' lives. Its epidemiology varies regionally; however, nationwide epidemiologic data on psoriasis depicting profile Korean patients has not been available to date.
Abstract: Neonatal hypocalcemia is not an uncommon condition, especially in the premature neonate. It effectively treated by intravenous administration of calcium gluconate. Complications extravasation during infusion include localized calcification and occasionally necrosis. When this occurs, however, there no specific mode treatment except supportive management skin graft. This experiment was designed to evaluate efficacy safety with triamcinolone acetonide calcinosis cutis following...
Background α‐hydroxyacids (AHA), such as glycolic acid and lactic acid, have recently been used in cosmetic dermatological formulations. However, the mechanisms of action these substances not well documented. Objectives This study was done to investigate effects AHA on skin barrier hairless mice clarify contribution formation secretion lamellar bodies (LB), which are known be critical structure for function epidermis. Methods 5% Lactic were applied normal daily 14 days. Results Changes...
Abstract Background Although occlusive dressings have great potential in the management of psoriasis vulgaris, therapeutic mechanism is not completely understood. Occlusion artificially restores and corrects defective barrier plaques. Additionally, occlusion know to normalize epidermal calcium gradients hyperproliferative murine skin models. Methods To investigate basis effect on psoriatic plaques, we investigated ultrastructural morphology intercorneocyte lipid layers, lamellar bodies,...
Cherry angiomas are a common cutaneous vascular proliferation which manifests as single or multiple spots and occurs predominantly on the upper trunk arms. They typically appear round-to-oval, bright, red, dome-shaped papules pinpoint macules measuring up to several millimeters in diameter. The histopathologic findings of cherry angioma consistent with true capillary hemangioma, is formed by numerous, newly developed capillaries narrow lumens prominent endothelial cells arranged lobular...
Abstract Three female patients affected by intradermal vascular tumors were presented. The lesions acquired and developed from preexisting port‐wine stains (PWS). Among the three observed, two had a pyogenic granuloma (PG) third patient tufted anigomas. As reported earlier, formation of PG within lesion PWS supports assumption that arteriovenous anastomoses are associated with its pathogenesis. Occurrence angioma PWS, as well coexisting but separate has been reported. However, angiomas our...
Three cases of a solitary neurofibroma showing focal fatty changes are reported. Fatty in rarely observed and have not been reported, also, the pathogenesis has clarified. We postulate that may be result so-called senescent change or chronic injury. The origin adipose cells attributable to infiltration from abutting tissues metaplasia tumor resident fibroblasts.
Abstract Abnormal follicular keralinization is important for comedo formation in acne, but the precise mechanism not known. A recent report about acne vulgaris suggested that an impaired water barrier function may be responsible formation, since dysfunction accompanied by hyperkeratosis of epithelium. Furthermore, integrity crucial maintenance epidermal calcium gradient. Yet stratum corneum intercellular lipid structures, a major factor skin function, and distribution epithelium comedones,...