A5035385618- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Influenza Virus Research Studies
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Infection Control and Ventilation
- Animal Virus Infections Studies
- Nosocomial Infections in ICU
- Flood Risk Assessment and Management
- Long-Term Effects of COVID-19
- Dermatological and COVID-19 studies
- Viral Infections and Immunology Research
- Antibiotic Resistance in Bacteria
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis B Virus Studies
- Viral Infections and Vectors
- Hydrology and Watershed Management Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Virus-based gene therapy research
- Travel-related health issues
- Precipitation Measurement and Analysis
Korea University
2016-2025
International Vaccine Institute
2022-2025
Korea University Medical Center
2020-2024
Weatherford College
2022
Samsung Medical Center
2021
Sungkyunkwan University
2021
Korea Meteorological Administration
2015
Inje University Busan Paik Hospital
2009
Maria Fertility Hospital
2006
Background: Patients with coronavirus disease 2019 (COVID-19) can unknowingly spread the virus to several people during early subclinical period.Methods: We evaluated viral dynamics in various body fluid specimens, such as nasopharyngeal swab, oropharyngeal saliva, sputum, and urine of two patients COVID-19 from hospital day 1 9. Additional samples saliva were taken at hour, 2 hours, 4 hours after using a chlorhexidine mouthwash.The severe acute respiratory syndrome (SARS-CoV-2) load was...
Social distancing has been adopted as one of basic protective measures against coronavirus disease 2019 (COVID-19).During 2019-2020 season, influenza epidemic period was exceptionally short and peak low in comparison with previous seasons Korea.Influenza pattern bimodal 2016-2017 2018-2019 seasons, however, viruses have rarely circulating spring, 2020 Korea.Although multiple factors could affect the size epidemic, extensive application nonpharmaceutical interventions including mask wearing...
Since it first emerged in December 2019, coronavirus disease 2019 (COVID-19) has spread rapidly worldwide. During the pandemic of an emerging infectious disease, is very important to prevent nosocomial outbreaks and operate hospitals safely maintain their functions. In this article, we present strategies for safe hospital operations based on experiences Republic Korea early COVID-19 pandemic. Each should multiple layers defenses even small cracks hospital's quarantine system.
Abstract The disease burden of respiratory syncytial virus (RSV) infection in the adult population has not been well characterized compared to children. Investigation clinical characteristics and RSV would help establish public health policy a future vaccine strategy. We retrospectively collected medical records hospitalized patients who were diagnosed with from January 2012 December 2015 three tertiary hospitals. Baseline characteristics, outcomes economic charge during hospitalization by...
Despite use of the 13-valent pneumococcal conjugate vaccine (PCV13) and 23-valent polysaccharide (PPSV23) over last decade, disease burden pneumonia is still high. We evaluated field effectiveness PCV13, PPSV23, sequential vaccination against in older adults.This prospective multicenter study was conducted adults aged ≥65 years hospitalized with community-acquired (CAP) between September 2015 August 2017. The case-control test-negative design used to estimate (VE) CAP.Of 1525 cases CAP...
In the 2023-2024 season, influenza epidemic in South Korea peaked earlier than recent years. this study, we aimed to estimate interim vaccine effectiveness (VE) of vaccination prevent during early season. From November 1, 2023, December 31, enrolled 2,632 subjects with influenza-like illness from eight hospitals participating hospital-based morbidity and mortality surveillance. A retrospective test-negative case-control study was conducted VE. The results showed an adjusted VE 22.5% (95%...
Background The assessment of long-term humoral and cellular immunity post-vaccination is crucial for establishing an optimal vaccination strategy. Methods This prospective cohort study evaluated adults (≥18 years) who received a BA.4/5 bivalent vaccine. We measured the anti-receptor binding domain immunoglobulin G antibody neutralizing antibodies (NAb) against wild-type Omicron subvariants (BA.5, BQ.1.1, BN.1, XBB.1 EG.5) up to 9 months post-vaccination. T-cell immune responses were before 4...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are pivotal in combating disease 2019 (COVID-19); however, the declining antibody titers postvaccination pose challenges for sustained protection and herd immunity. Although gut microbiome is reported to affect early response after vaccination, its impact on longevity of vaccine-induced antibodies remains unexplored.
Pneumonia is a leading infectious cause of morbidity and mortality among adults. Pneumococcal pneumonia (PP) the most common vaccine-preventable bacterial etiology pneumonia. In this study, we estimated incidence community-acquired (CAP) pneumococcal diseases Korean adults.Clinical microbiological databases from three hospitals were retrospectively reviewed to determine case fatality rates CAP in adults aged ≥19 years 2011 2014. Incidence CAP, PP invasive (IPD) evaluated based on catchment...
Serosurveillance studies reveal the actual disease burden and herd immunity level in population. In Seoul, Korea, a cross-sectional investigation showed 0.07% anti-severe acute respiratory syndrome coronavirus-2 antibody seropositivity among 1,500 outpatients of university hospitals. Low seroprevalence reflects well-implemented social distancing. should be repeated as pandemic progresses.
There is insufficient data on the longevity of immunity acquired after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Objectives Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects gut luminal cells through the angiotensin-converting enzyme-2 receptor and disrupts microbiome. We investigated whether microbiome in early stage of SARS-CoV-2 infection was associated with prognosis disease (COVID-19). Methods Thirty COVID-19 patients 16 healthy controls were prospectively enrolled. Blood stool samples clinical details collected on days 0 (enrollment), 7, 14, 28. Participants categorized into...
Abstract Background Influenza imposes a significant healthcare burden in Korea, leading the government to initiate national immunization program. Previous studies on vaccine effectiveness (VE) were limited single-season estimation Korea. Matching status of epidemic influenza virus strains and each season from 2011/2012 2020/2021 seasons Methods This multicenter prospective cohort study enrolled patients with influenza-like illnesses at 10 medical centers Korea 2011–2021. The demographic...
Abstract Background On May 5, 2023, the World Health Organization declared end of public health emergency for COVID-19, marking transition into endemic era. In situation, there is limited data on epidemiological respiratory virus infections. This study aimed to compare epidemiology and clinical outcomes three representative viral infections (COVID-19, influenza RSV).Table 1.Baseline characteristics influenza, RSV.Data are presented as mean±SD or No (%).HTN, Hypertension; DM, Diabetes...
During the 2023-2024 season, influenza epidemic in South Korea peaked earlier, and vaccination rate among individuals aged ≥ 65 was high (82.2%). However, data on real-world vaccine effectiveness against are lacking. From November 2023 to April 2024, we conducted a multicenter retrospective case-control study adult patients 18 years who presented with influenza-like illness at seven medical centers as part of hospital-based morbidity mortality surveillance (HIMM) program Korea. Demographic...
South Korea's current vaccination policies leave a surveillance gap for non-National Immunization Program (NIP) vaccines. In this study, we proposed sentinel approach monitoring the safety of non-NIP Vaccination data were collected retrospectively among patients hospitalized with pre-defined adverse events special interest (AESI) by reviewing electronic medical records in five university hospitals. This incorporates expert assessment to determine causal relationship. We confirmed that 16 had...
Pneumonia is a leading cause of hospitalization and mortality worldwide. Despite recognition the importance community-acquired pneumonia (CAP) in adults, limited epidemiologic information available South Korea. This study aimed to evaluate disease burden hospitalized CAP adults aged ≥19 years its trend using Health Insurance Review Assessment (HIRA) data. retrospective HIRA database from year 2009 2013. We estimated incidence rate direct medical cost These were further analyzed with respect...
Face masks are used to protect the wearer from harmful external air and prevent transmission of viruses exhaled by potentially infected wearers surrounding people. In this study, we examined potential utility for collecting contained in breath detected collected via various molecular tests. Using KF94 masks, inner electrostatic filter was selected virus collection, an RNA extraction protocol developed face mask. Virus detection worn mask samples performed using PCR rolling circle...
Background Whether or not a single-dose Ad26.COV2.S prime and boost vaccination induces sufficient immunity is unclear. Concerns about the increased risk of breakthrough infections in Ad26.COV2.S-primed population have also been raised. Methods A prospective cohort study was conducted. Participants included healthy adults who were primed scheduled to receive booster with BNT162b2, mRNA-1273, Ad26.COV2.S. The IgG anti-receptor binding domain (RBD) antibody titers, neutralizing (NAb) titers...
Carbapenem-resistant Acinetobacter baumannii (CRAB) pneumonia has been a serious problem in the intensive care unit (ICU). However, defined characteristics of respiratory microbiome CRAB are lacking nowadays. This study aimed to analyze compared non-CRAB and reveal clinical significance data these patients. Patients diagnosed with severe mechanical ventilation were enrolled ICU tertiary hospital. Respiratory specimens collected on days 1, 4, 7, 14 each participant via tracheal aspiration....