A5049750727- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Epigenetics and DNA Methylation
- Heat transfer and supercritical fluids
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Stress Responses and Cortisol
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Plant Surface Properties and Treatments
- GDF15 and Related Biomarkers
- Circadian rhythm and melatonin
- Rocket and propulsion systems research
- Cardiovascular Disease and Adiposity
- Dietary Effects on Health
- Fluid Dynamics and Heat Transfer
- Remote Sensing and LiDAR Applications
- Chromatin Remodeling and Cancer
- Fibroblast Growth Factor Research
- Heat Transfer and Boiling Studies
- Birth, Development, and Health
- Protein Kinase Regulation and GTPase Signaling
Southeast University
2024
Beijing Academy of Agricultural and Forestry Sciences
2023
National Engineering Research Center for Information Technology in Agriculture
2023
Anhui University of Science and Technology
2023
Fudan University
2022-2023
Zhongshan Hospital
2022-2023
State Key Laboratory of Medical Neurobiology
2022-2023
Anhui Science and Technology University
2023
University of Chinese Academy of Sciences
2017-2022
Shanghai Institute of Nutrition and Health
2018-2022
The mechanisms underlying glucocorticoid (GC)-increased adiposity are poorly understood. Brown adipose tissue (BAT) acquires white (WAT) cell features defined as BAT whitening under certain circumstances. aim of our current study was to investigate the possibility and GC-induced whitening. Here, we showed that one-week dexamethasone (Dex) treatment induced whitening, characterized by lipid droplet accumulation, in vitro vivo. Furthermore, autophagy ATG7 (autophagy related 7) expression Dex,...
Abstract The thyroid hormone (TH)-controlled recruitment process of brown adipose tissue (BAT) is not fully understood. Here, we show that long-term treatment T3, the active form TH, increases thermogenic capacity in interscapular BAT male mice through hyperplasia by promoting TH receptor α-mediated adipocyte progenitor cell proliferation. Our single-cell analysis reveals heterogeneous nature and hierarchical trajectory within cells BAT. Further analyses suggest T3 facilitates state...
Abstract The browning of white adipose tissue (WAT) has got much attention for its potential beneficial effects on metabolic disorders, however, the nutritional factors and neuronal signals involved remain largely unknown. We sought to investigate whether WAT is stimulated by leucine deprivation, amino acid sensor, general control non-derepressible 2 (GCN2), in amygdalar protein kinase C-δ (PKC-δ) neurons contributes this regulation. Our results show that deficiency can induce browning,...
Liver steatosis, a condition in which lipid accumulates liver cells, is leading cause of many diseases. The livers patients with hepatocellular carcinoma, cancer characterized by have decreased abundance the transcription cofactor BTG1 (B cell translocation gene 1). We showed that db/db mice, are genetic model obesity, had mRNA and protein abundance. overexpression ameliorated steatosis whereas knockdown induced wild-type mice. Consistent these changes, we found triglyceride accumulation...
Although many functions of activating transcription factor 4 (ATF4) are identified, a role ATF4 in the hypothalamus regulating energy homeostasis is unknown. Here, we generated adult-onset agouti-related peptide neuron–specific knockout (AgRP-ATF4 KO) mice and found that these were lean, with improved insulin leptin sensitivity decreased hepatic lipid accumulation. Furthermore, AgRP-ATF4 KO showed reduced food intake increased expenditure, mainly because enhanced thermogenesis brown adipose...
Lysosomal amino acid accumulation is implicated in several diseases, but its role insulin resistance, the central mechanism to type 2 diabetes and many metabolic unclear. In this study, we show hepatic expression of lysosomal membrane protein solute carrier family 7 member 14 (SLC7A14) increased insulin-resistant mice. The promoting effect SLC7A14 on resistance demonstrated by loss- gain-of-function experiments. further as a transporter resulting γ-aminobutyric (GABA), which induces via...
Although many biological functions of activating transcription factor 4 (ATF4) have been identified, a role hypothalamic ATF4 in the regulation energy homeostasis is poorly understood. In this study, we showed that proopiomelanocortin (POMC) neuron-specific knockout (PAKO) mice are lean and higher expenditure. Furthermore, PAKO were resistant to high-fat diet-induced obesity, glucose intolerance, leptin resistance. Moreover, expression autophagy protein 5 (ATG5) was increased or decreased by...
The canopy volume of fruit trees is an important input for the precise and varying application pesticides in orchards. fixed mesh division method mostly used to calculate volumes with variable target-oriented spraying. To reduce influence working speed on detection accuracy under a width division, cuboid accumulation divided areas (CADAs), which light ranging (LiDAR) online tree based dynamic proposed this paper. In method, area according number unilateral nozzles sprayer height direction...
Although the central nervous system has been implicated in glucocorticoid-induced gain of fat mass, underlying mechanisms are poorly understood. The aim this study was to investigate possible involvement hypothalamic serum- and glucocorticoid-regulated kinase 1 (SGK1) glucocorticoid-increased adiposity. It is well known that SGK1 expression induced by acute glucocorticoid treatment, but it interesting we found its be decreased arcuate nucleus hypothalamus, including proopiomelanocortin...
ATF4 (activating transcription factor 4) is an important that has many biological functions, while its role in hypothalamic POMC (pro-opiomelanocortin-α) neurons the regulation of energy homeostasis not been explored. We recently discovered mice with Atf4 deletion specific to (PAKO mice) are lean and have higher expenditure. Furthermore, these resistant high-fat diet (HFD)-induced obesity obesity-related metabolic disorders. Mechanistically, we found expression ATG5 (autophagy-related 5)...
c-Jun, a prominent member of the activator protein 1 (AP-1) family, is involved in various physiology processes such as cell death and survival. However, role hepatic c-Jun whole-body metabolism poorly understood. We generated liver-specific knock-out (c-jun△li) mice to investigate effect on physiology, particularly blood glucose body temperature. Primary hepatocytes were also used explore direct regulation gluconeogenesis. c-jun△li showed higher gluconeogenic capacity compared with control...
Short-term tamoxifen treatment has effects on lipid and glucose metabolism in mice fed chow. However, its high-fat diet (HFD) the underlying mechanisms are unclear. Here, we show that for 5 days decreases fat mass as long 18 weeks HFD. Tamoxifen alters mRNA levels of some genes involved white adipose tissue improves insulin tolerance well hepatic signaling 12-20 weeks. Proopiomelanocortin (POMC) neuron-specific deletion nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) attenuates...
Abstract Background Leucine deprivation modulates the dietary amino acid composition, reducing fat content and improving glucose tolerance, thus protecting organism against obesity. However, a complete of leucine can lead to an extremely rapid loss in mice, accompanied by prolonged adverse effects such as weakness mental fatigue. Therefore, this study we aimed seek optimal concentration that reduce mass improve metabolism without onset severe effects. Methods To investigate whether there is...
We have previously shown that leucine deprivation stimulates browning and lipolysis in white adipose tissue (WAT), which helps to treat obesity. Adipose macrophages (ATMs) significantly influence WAT lipolysis. However, it is unclear whether ATMs are involved deprivation-induced WAT; the associated signals remain be elucidated. Here, we investigated role of possible mechanisms under leucine-deprivation conditions. In this study, were depleted mice by injecting clodronate-liposomes (CLOD)...
Friend of GATA 2 (FOG2) is a transcriptional cofactor involved mostly in cardiac function. The aim this study was to investigate the role hepatic FOG2 insulin sensitivity and lipid accumulation. overexpression by adenovirus-expressing (Ad-FOG2) significantly attenuates signaling hepatocytes vitro. Opposite effects were observed when knocked down through small hairpin RNA for (Ad-shFOG2). Furthermore, knockdown Ad-shFOG2 ameliorated resistance leptin receptor–mutated (db/db) mice, Ad-FOG2...
Essential amino acids (EAAs) are crucial nutrients, whose levels change in rodents and patients with depression. However, how the of a single EAA affects depressive behaviors remains elusive. Here, we demonstrate that although deprivation leucine has no effect unstressed mice, it remarkably reverses depression-like induced by chronic restraint stress (CRS). This beneficial is independent feeding applicable to dietary deficiency other EAAs. Furthermore, suppressed central injection or...
Although the hypothalamus is crucial for peripheral metabolism control, signals in specific neurons involved remain poorly understood. The aim of our current study was to explore role hypothalamic gene mothers against decapentaplegic homolog 7 (Smad7) glucose disorders. We studied high-fat diet (HFD)-fed mice and middle-aged with Cre-mediated recombination causing 1) overexpression Smad7 proopiomelanocortin (POMC) neurons, 2) deletion POMC 3) protein kinase B (AKT) arcuate nucleus (ARC)...
Abstract Angiotensin-converting enzyme 2 (ACE2) has been identified as a primary receptor for severe acute respiratory syndrome coronaviruses (SARS-CoV-2). Here, we investigated the expression regulation of ACE2 in enterocytes under amino acid deprivation conditions. In this study, found that was upregulated upon all or single essential human colonic epithelial CCD841 cells. Furthermore, knockdown general control nonderepressible ( GCN2 ) reduced intestinal mRNA and protein levels vitro...
Color image super-resolution reconstruction based on the sparse representation model usually adopts regularization norm (e.g., L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> or xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ). These methods have limited ability to keep texture detail some extent and are easy cause problem of blurring details color artifacts in reconstructed images. This paper presents a method combining /...
Leucine deprivation improves insulin sensitivity; however, whether and how this effect can be extended are unknown. We hypothesized that intermittent leucine (ILD) might produce a long-term on improved sensitivity via the formation of metabolic memory. Consistently, seven ILD cycles treatment (1-day leucine-deficient diet, 3-day control diet) in mice produced long-lasting (after diet was resumed for 49 days) whole-body hepatic mice, indicating potential Furthermore, effects depended general...
Impairment of gluconeogenesis is a key factor responsible for hyperglycemia in patients with type 2 diabetes. As an important member the suppressors cytokine signaling (SOCS) protein family, many physiological functions cytokine-inducible SH2-containing (CISH) have been described; however, role hepatic CISH poorly understood. In present study, we observed that expression was reduced fasted wild-type (WT) mice. Overexpression decreased glucose production mouse primary hepatocytes, while...