A5052000288- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Galectins and Cancer Biology
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Alkaline Phosphatase Research Studies
- Cardiovascular Disease and Adiposity
- Stress Responses and Cortisol
- Liver physiology and pathology
- Cytokine Signaling Pathways and Interactions
- Marine Bivalve and Aquaculture Studies
- Marine Biology and Ecology Research
- Circadian rhythm and melatonin
- Aquatic Invertebrate Ecology and Behavior
- Immune Response and Inflammation
- Ginger and Zingiberaceae research
- Diet, Metabolism, and Disease
- Neuroendocrine regulation and behavior
- Metabolomics and Mass Spectrometry Studies
- Growth Hormone and Insulin-like Growth Factors
- Traditional Chinese Medicine Analysis
- Protein Kinase Regulation and GTPase Signaling
- Barrier Structure and Function Studies
The First Affiliated Hospital, Sun Yat-sen University
2025
Zhongshan Hospital
2024-2025
Fudan University
2024-2025
Sun Yat-sen University
2025
State Key Laboratory of Medical Neurobiology
2024-2025
Ministry of Agriculture and Rural Affairs
2024
Chinese Academy of Fishery Sciences
2024
Shanghai Institute of Nutrition and Health
2020-2023
University of Chinese Academy of Sciences
2020-2023
ORCID
2020
Abstract Gut microbiota is linked to human metabolic diseases. The previous work showed that leucine deprivation improved dysfunction, but whether alters certain specific species of bacterium brings these benefits remains unclear. Here, this finds gut composition, which sufficient and necessary for the improvements induced by deprivation. Among all affected bacteria, B. coccoides markedly increased in feces leucine‐deprived mice. Moreover, gavage with improves insulin sensitivity reduces...
Abstract An important role for liver in the regulation of adipose tissue thermogenesis upon cold exposure has been suggested; however, underlying mechanisms remain incompletely defined. Here, we identify elevated serum bradykinin levels response to acute male mice. A bolus anti-bradykinin antibodies reduces body temperature during exposure, whereas opposite effect. We demonstrate that induces brown and white browning, increases uncoupling protein 1 (UCP1) expression tissue. The B2 receptor...
Abstract The browning of white adipose tissue (WAT) has got much attention for its potential beneficial effects on metabolic disorders, however, the nutritional factors and neuronal signals involved remain largely unknown. We sought to investigate whether WAT is stimulated by leucine deprivation, amino acid sensor, general control non-derepressible 2 (GCN2), in amygdalar protein kinase C-δ (PKC-δ) neurons contributes this regulation. Our results show that deficiency can induce browning,...
Chronic stress induces depression- and anxiety-related behaviors, which are common mental disorders accompanied not only by dysfunction of the brain but also intestine. Activating transcription factor 4 (ATF4) is a stress-induced gene, we previously show that it important for gut functions; however, contribution intestinal ATF4 to stress-related behaviors known. Here, chronic inhibits expression in epithelial cells. overexpression colon relieves behavioral alterations male mice, as measured...
Lysosomal amino acid accumulation is implicated in several diseases, but its role insulin resistance, the central mechanism to type 2 diabetes and many metabolic unclear. In this study, we show hepatic expression of lysosomal membrane protein solute carrier family 7 member 14 (SLC7A14) increased insulin-resistant mice. The promoting effect SLC7A14 on resistance demonstrated by loss- gain-of-function experiments. further as a transporter resulting γ-aminobutyric (GABA), which induces via...
Amino acid sensing in the central nervous system plays a key role regulating energy homeostasis. The anterior piriform cortex (APC) has been implicated amino deficiency and rapidly inducing an aversive response. However, precise types of neurons involved whether they possess additional metabolic regulatory functions remain to be elucidated. study reveals that corticotropin-releasing hormone (CRH) APC (APCCRH neurons) are activated by leucine-deficient diet modulate brown adipose tissue...
Abstract Adipocyte metabolism critically regulates systemic energy homeostasis, and its dysfunction contributes to obesity pathogenesis. Notably, elevated circulating branched-chain amino acid (BCAA) levels impaired adipose tissue BCAA catabolism have been observed in both animal models humans with obesity; however, the mechanisms underlying metabolism’s regulation of adipocyte function remain incompletely understood. This review synthesizes recent advances roles catabolic enzymes, their...
Chronic inflammation in liver induces insulin resistance systemically and other tissues, including the skeletal muscle (SM); however, underlying mechanisms remain largely unknown. RNA sequencing of primary hepatocytes from wild-type mice fed long-term high-fat diet (HFD), which have severe chronic revealed that expression hepatokine endoplasmic reticulum aminopeptidase 1 (ERAP1) was upregulated by a HFD. Increased ERAP1 levels were also observed interferon-γ–treated hepatocytes. Furthermore,...
Abstract Sinosolenaia oleivora (Bivalve, Unionida, Unionidae), is a near-endangered edible mussel. In 2022, it was selected by the Ministry of Agriculture and Rural Affairs as top-ten aquatic germplasm resource, with potential for industrial development. Using Illumina, PacBio, Hi-C technology, high-quality chromosome-level genome S. assembled. The assembled spanned 2052.29 Mb contig N50 size 20.36 scaffold 103.57 Mb. 302 contigs, accounting 98.41% total genome, were anchored into 19...
We have previously shown that leucine deprivation stimulates browning and lipolysis in white adipose tissue (WAT), which helps to treat obesity. Adipose macrophages (ATMs) significantly influence WAT lipolysis. However, it is unclear whether ATMs are involved deprivation-induced WAT; the associated signals remain be elucidated. Here, we investigated role of possible mechanisms under leucine-deprivation conditions. In this study, were depleted mice by injecting clodronate-liposomes (CLOD)...
Essential amino acids (EAAs) are crucial nutrients, whose levels change in rodents and patients with depression. However, how the of a single EAA affects depressive behaviors remains elusive. Here, we demonstrate that although deprivation leucine has no effect unstressed mice, it remarkably reverses depression-like induced by chronic restraint stress (CRS). This beneficial is independent feeding applicable to dietary deficiency other EAAs. Furthermore, suppressed central injection or...
Although the hypothalamus is crucial for peripheral metabolism control, signals in specific neurons involved remain poorly understood. The aim of our current study was to explore role hypothalamic gene mothers against decapentaplegic homolog 7 (Smad7) glucose disorders. We studied high-fat diet (HFD)-fed mice and middle-aged with Cre-mediated recombination causing 1) overexpression Smad7 proopiomelanocortin (POMC) neurons, 2) deletion POMC 3) protein kinase B (AKT) arcuate nucleus (ARC)...
Impairment of gluconeogenesis is a key factor responsible for hyperglycemia in patients with type 2 diabetes. As an important member the suppressors cytokine signaling (SOCS) protein family, many physiological functions cytokine-inducible SH2-containing (CISH) have been described; however, role hepatic CISH poorly understood. In present study, we observed that expression was reduced fasted wild-type (WT) mice. Overexpression decreased glucose production mouse primary hepatocytes, while...
To investigate the hypothesis that APS can attenuate E. coli-induced microvascular dysfunction in chicken intestine, 60 0-day old male chickens were divided into three groups with 5 replications of 4 chicks. Chicken group treated 15 mg daily while others given 0 for 6 days. Then all 7-day injected intraperitoneally by coli, except control group. After h, chicken's intestinal samples collected to detect gene expressions involved inflammatory factors and adhesion molecules. Results showed...
Abstract The current study aimed to investigate the role of endoplasmic reticulum aminopeptidase 1 (ERAP1), a novel hepatokine, in whole-body glucose metabolism. Here, we found that hepatic ERAP1 levels were increased insulin-resistant leptin-receptor-mutated (db/db) and high-fat diet (HFD)-fed mice. Consistently, overexpression attenuated skeletal muscle (SM) insulin sensitivity, whereas knockdown ameliorated SM resistance. Furthermore, serum positively correlated, recombinant mouse or...
Chronic inflammation in liver induces insulin resistance systemically and other tissues, including the skeletal muscle (SM); however, underlying mechanisms remain largely unknown. By performing RNA-seq of primary hepatocytes from wild-type mice fed long term high-fat diet (HFD), which have severe chronic resistance, we found that expression hepatokine endoplasmic reticulum aminopeptidase 1 (ERAP1) was upregulated by HFD. Increased ERAP1 levels were also observed interferon-γ-treated...
Chronic inflammation in liver induces insulin resistance systemically and other tissues, including the skeletal muscle (SM); however, underlying mechanisms remain largely unknown. By performing RNA-seq of primary hepatocytes from wild-type mice fed long term high-fat diet (HFD), which have severe chronic resistance, we found that expression hepatokine endoplasmic reticulum aminopeptidase 1 (ERAP1) was upregulated by HFD. Increased ERAP1 levels were also observed interferon-γ-treated...