A5072876748- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Gastrointestinal Tumor Research and Treatment
- Vascular Tumors and Angiosarcomas
- Cancer Genomics and Diagnostics
- Cardiac tumors and thrombi
- Advanced Breast Cancer Therapies
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal disorders and treatments
- Soft tissue tumor case studies
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Bone Tumor Diagnosis and Treatments
- Protein Degradation and Inhibitors
- RNA Research and Splicing
- Glioma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Neurofibromatosis and Schwannoma Cases
- CAR-T cell therapy research
- RNA modifications and cancer
- Soft tissue tumors and treatment
- Lymphoma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
Memorial Sloan Kettering Cancer Center
2016-2025
Northwell Health
2023-2025
Hackensack University Medical Center
2014-2024
Cornell University
2014-2024
Kettering University
1953-2024
North Shore University Hospital
2024
Dana-Farber Cancer Institute
1993-2023
Sarcoma Oncology Center
2004-2023
University of Turku
2003-2023
Oregon Health & Science University
1996-2023
Constitutive activation of KIT receptor tyrosine kinase is critical in the pathogenesis gastrointestinal stromal tumors. Imatinib mesylate, a selective inhibitor, has been shown preclinical models and preliminary clinical studies to have activity against such
Most gastrointestinal stromal tumors (GISTs) have activating mutations in the KIT receptor tyrosine kinase, and most patients with GISTs respond well to Gleevec, which inhibits kinase activity. Here we show that ∼35% (14 of 40) lacking intragenic activation related platelet-derived growth factor α ( PDGFRA ). Tumors expressing or oncoproteins were indistinguishable respect downstream signaling intermediates cytogenetic changes associated tumor progression. Thus, appear be alternative...
Purpose: Most gastrointestinal stromal tumors (GISTs) express constitutively activated mutant isoforms of KIT or kinase platelet-derived growth factor receptor alpha (PDGFRA) that are potential therapeutic targets for imatinib mesylate. The relationship between mutations in these kinases and clinical response to was examined a group patients with advanced GIST. Patients Methods: GISTs from 127 enrolled onto phase II study were PDGFRA. Mutation types correlated outcome. Results: Activating...
Abstract Most gastrointestinal stromal tumors (GIST) have an activating mutation in either KIT or PDGFRA. Imatinib is a selective tyrosine kinase inhibitor and achieves partial response stable disease about 80% of patients with metastatic GIST. It now clear that some GIST develop resistance to imatinib during chronic therapy. To identify the mechanism resistance, we studied 31 who were treated then underwent surgical resection. There 13 nonresistant imatinib, 3 primary 15 acquired after...
Induction of terminal differentiation represents a promising therapeutic approach to certain human malignancies. The peroxisome proliferator-activated receptor γ (PPARγ) and the retinoid X α (RXRα) form heterodimeric complex that functions as central regulator adipocyte differentiation. Natural synthetic ligands for both receptors have been identified. We demonstrate here PPARγ is expressed at high levels in each major histologic types liposarcoma. Moreover, primary liposarcoma cells can be...
To test the feasibility of noninvasive magnetic resonance (MR) imaging-guided focused ultrasound surgery (FUS) benign fibroadenomas in breast.Eleven nine patients under local anesthesia were treated with MR FUS. Based on a T2-weighted definition target volumes, sequential sonications delivered to treat entire target. Temperature-sensitive phase-difference-based imaging was performed during each sonication monitor focus localization and tissue temperature changes. After procedure, contrast...
The aim of this study was to determine the pattern recurrence and prognostic significance histologic subtype in a large series patients with primary retroperitoneal liposarcoma.Classification liposarcoma into subtypes, based on morphologic features cytogenetic aberrations, is now widely accepted. Previous studies have shown that high grade incomplete gross resection are most important factors for survival sarcoma suggest 3-fold higher risk local compared other histologies.A prospective...
We conducted a Phase I clinical trial investigating the biologic activity of vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage colony-stimulating factor in patients metastatic melanoma. Immunization sites were intensely infiltrated T lymphocytes, dendritic cells, macrophages, and eosinophils all 21 evaluable patients. Although lesions resected before minimally immune system patients, after densely lymphocytes plasma showed extensive...
The prostate-specific membrane antigen (PSMA) targeted positron-emitting-tomography (PET) tracer 68Ga-PSMA-11 shows great promise in the detection of prostate cancer. However, 68Ga has several shortcomings as a radiolabel including short half-life and non-ideal energies, this motivated consideration 18F-labelled analogs. 18F-PSMA-1007 was selected among 18F-PSMA-ligand candidate compounds because it demonstrated high labelling yields, outstanding tumor uptake fast, non-urinary background...
Abstract The classification of epithelioid vascular tumors remains challenging, as there is considerable morphological overlap between tumor subtypes, across the spectrum from benign to malignant categories. A t(1;3)(p36.3;q25) translocation was reported in two cases hemangioendothelioma (EHE), however, no follow‐up studies have been performed identify gene fusion or assess its prevalence a larger cohort patients. We undertook systematic molecular analysis 17 EHE, characterized by classic...
Agonist ligands for the nuclear receptor peroxisome proliferator-activated receptor-γ have been shown to induce terminal differentiation of normal preadipocytes and human liposarcoma cells in vitro . Because status is predictive clinical outcomes, modulation a tumor may favorably impact behavior. We conducted trial treatment patients with advanced by using ligand troglitazone, which extensive correlative laboratory studies were performed. report here results three intermediate high-grade...
Abstract BACKGROUND. Gastrointestinal stromal tumor (GIST) is the most frequent sarcoma of intestinal tract and often shows constitutive activation either KIT or PDGFRA receptor tyrosine kinases because gain‐of‐function mutation. Although efficacy kinase inhibitors in metastatic GIST depends on mutation status, there have been conflicting reports prognostic importance primary GIST. METHODS. A total 127 patients were studied who presented to our institution from 1983 2002 with localized...