A5035733499- PI3K/AKT/mTOR signaling in cancer
- Bone Metabolism and Diseases
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- Bone health and treatments
- Osteoarthritis Treatment and Mechanisms
- Mast cells and histamine
- Autophagy in Disease and Therapy
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Venous Thromboembolism Diagnosis and Management
- Cancer-related molecular mechanisms research
- Tuberous Sclerosis Complex Research
- Protein Kinase Regulation and GTPase Signaling
- Acute Myocardial Infarction Research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cell death mechanisms and regulation
- Hematopoietic Stem Cell Transplantation
- Insect-Plant Interactions and Control
- Genetic factors in colorectal cancer
- Biochemical effects in animals
- Natural product bioactivities and synthesis
- Protein Hydrolysis and Bioactive Peptides
Southern Medical University
2016-2025
Guizhou University
2025
Zhengzhou University
2023
Jiangxi Academy of Agricultural Sciences
2020-2022
Animal Science Research Institute
2020-2022
Nanjing University of Finance and Economics
2019-2022
Third Affiliated Hospital of Southern Medical University
2021
Yantaishan Hospital
2016
Binzhou University
2016
Binzhou Medical University
2016
It has been established that reactive oxygen species (ROS) such as H2O2 or superoxide anion is involved in bone loss-related diseases by stimulating osteoclast differentiation and resorption receptor activator of NF-κB ligand (RANKL) a critical osteoclastogenic factor expressed on stromal/osteoblastic cells. However, the roles ROS RANKL expression signaling mechanisms through which regulates genes are not known. Here we report increased intracellular levels xanthine/xanthine...
Abstract Exosomes are small membrane‐bound vesicles released into extracellular spaces by many types of cells. These nanovesicles carry proteins, mRNA, and miRNA, involved in cell waste management intercellular communication. In the present study, it is shown that exosome release, which leads to net loss cellular membrane protein content, negatively regulated mechanistic target rapamycin complex 1 (mTORC1). It found cells animal models release inhibited sustained activation mTORC1, leading...
Abstract Clinical evidence has established that concomitant traumatic brain injury (TBI) accelerates bone healing, but the underlying mechanism is unclear. This study shows after TBI, injured neurons, mainly those in hippocampus, release osteogenic microRNA (miRNA)-enriched small extracellular vesicles (sEVs), which targeted osteoprogenitors to stimulate formation. We show miR-328a-3p and miR-150-5p, enriched sEVs promote osteogenesis by directly targeting 3′UTR of FOXO4 or CBL ,...
Although protein kinase D3 (PKD3) has been shown to contribute prostate cancer cell growth and survival, the role of PKD in motility remains unclear. Here, we show that PKD2 PKD3 promote nuclear factor kappa B (NF-κB) signaling urokinase-type plasminogen activator (uPA) expression/activation, which are crucial for invasion. Silencing endogenous and/or markedly decreased migration invasion, reduced uPA receptor (uPAR) expression increased inhibitor-2 (PAI-2) expression. These results were...
Bioactive peptides from plant protein sources have been continuously identified as nutrient supplements for low toxicity but multiple physiological activities such antihypertensive, antioxidant, and anti-inflammatory. In this study, wheat bran isolate was digested with alcalase to produce hydrolysate (WPH) that then separated into different peptide fractions (<1, 1–3, 3–5, 5–10 kDa) by membrane ultrafiltration. WPH the were evaluated in vitro renin inhibition, angiotensin-converting enzyme...
Various food-derived bioactive peptides have been found with potential anti-inflammatory effects. Millet bran peptide is a extracted from millet bran, by-product of processing. In this study, the effect was investigated. A lipopolysaccharide (LPS)-induced RAW264.7 cell and an animal experiment model were established to test activity in vitro. As indicated by results, could significantly reduce levels inflammatory factors, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β)...
Abstract Accumulation of obsolete biomolecules can accelerate cell senescence and organism aging. The two efficient intracellular systems, namely the ubiquitin‐proteasome system autophagy‐lysosome system, play important roles in dealing with cellular wastes. However, how multicellular organisms orchestrate processing molecules delay aging remains unclear. Herein, it is shown that prevention exosome release by GW4869 or Rab27a −/− accelerated various cells mice, while stimulating nutrient...
Abnormal subchondral bone remodeling plays a pivotal role in the progression of osteoarthritis (OA). Here, we analyzed samples from OA patients and observed significant upregulation ubiquitin carboxy-terminal hydrolase L1 (UCHL1) specifically osteoclasts. Notably, found strong correlation between UCHL1 expression osteoclast activity during both human murine models. Conditional deletion precursors exacerbated progression, while its overexpression, mediated by adeno-associated virus 9,...
Sertoli cells (SCs) play a central role in testis development, and their normal number functions are required for spermatogenesis. Although the canonical tuberous sclerosis complex-mammalian target of rapamycin complex 1(TSC-mTORC1) pathway is critical development spermatogenesis, signaling mechanisms governing SC remain unclear. In this study, we generated two SC-specific mouse mutants using Cre-LoxP system. Loss Raptor (a key component mTORC1) caused severe tubular degeneration neonatal...
Previous studies have reported that mTORC2 promotes cell survival through phosphorylating AKT and enhancing its activity. We reveal another mechanism by which controls apoptosis. Inactivation of binding CIP2A to PP2A, leading reduced PP2A activity toward c-Myc serine 62 and, consequently, enhancement phosphorylation expression. Increased induces transcription pri-miR-9-2/miR-9-3p, in turn inhibiting expression E2F1, a transcriptional factor critical for cancer tumor progression, resulting...
The mechanism by which brown adipose tissue (BAT) regulates bone metabolism is unclear. Here, we reveal that BAT secretes S100A8/A9, a previously unidentified adipokine (batokine), to impair formation. Brown adipocytes-specific knockout of
Antheraea pernyi Guerin-Meneville eggs have become an important host for rearing Trichogramma and are the preferred mass production of dendrolimi Mausumura, a widely used natural enemy in pest control practices. However, effects fertilization on their remains unclear. In this study, we evaluated parasitism biological parameters T. reared A. with five different treatments under laboratory conditions. The were manually-extracted unfertilized washed (MUW), naturally-laid (NUW) unwashed (NUUW)...
Trichogramma wasps are mass-produced widely for biological control of various lepidoptera pests in agroforestry ecosystem. During the production, quality can be affected by many factors. One critical factor is clutch size reared on large host eggs. This study evaluated effect dendrolimi Antheraea pernyi Optimal sizes (40-60 or 60-80 eggs/clutch) resulted higher fecundity (174.5 135.6 eggs/female), emergence rate (91.14% 90.69%), adult longevity (16.85 16.55 days), flight ability (82.17%...
Non-shivering thermogenesis of brown adipose tissue (BAT) is tightly controlled by neural innervation. However, the underlying mechanism remains unclear. Here, we reveal that BAT regulates its own thermoadaptive innervation crosstalk with Schwann cells (SCs). Loss Olfm4 (encoding Olfactomedin-4), a risk gene in human obesity, causes dysfunction and reduces whole-body thermogenesis, predisposing to obesity mice. Mechanistically, BAT-derived OLFM4 traps Noggin, an endogenous inhibitor BMPs,...
Phospholipase C-γ1 (PLC-γ1) activation has been reported to enhance cell survival during the cellular response oxidative stress. We studied role of protein kinase C (PKC) pathways in mediating PLC-γ1 signalling stress by using mouse embryonic fibroblasts genetically deficient (Plcg1−/−) and its wild type (Plcg1+/+). was activated H2O2 treatment a dose- time-dependent manner. Activation PKC also markedly increased both lines treated with (1–5mM), but low doses (50–200μM), considerably...
Astrocytes respond to CNS insults through reactive astrogliosis, but the underlying mechanisms are unclear. In this study, we show that inactivation of mechanistic target rapamycin complex (mTORC1) signaling in postnatal neurons induces astrogliosis mice. Ablation Raptor (an mTORC1-specific component) postmitotic abolished mTORC1 activity and produced with smaller soma fewer dendrites, resulting microcephaly aberrant behavior adult Interestingly, extensive without significant astrocyte...