A5088918521- Osteoarthritis Treatment and Mechanisms
- Bone health and treatments
- Marine and fisheries research
- Mycotoxins in Agriculture and Food
- Microbial Metabolism and Applications
- Bone Metabolism and Diseases
- Total Knee Arthroplasty Outcomes
- Cephalopods and Marine Biology
- Spine and Intervertebral Disc Pathology
- Radiomics and Machine Learning in Medical Imaging
- Bone health and osteoporosis research
- Inflammatory mediators and NSAID effects
- Isotope Analysis in Ecology
- Rheumatoid Arthritis Research and Therapies
- Essential Oils and Antimicrobial Activity
- Genomics and Phylogenetic Studies
- Microbial Natural Products and Biosynthesis
- Medicinal Plants and Neuroprotection
- Musculoskeletal synovial abnormalities and treatments
- Plant-Microbe Interactions and Immunity
- Spinal Fractures and Fixation Techniques
- Genetic Associations and Epidemiology
- Identification and Quantification in Food
- Fungal and yeast genetics research
- Ichthyology and Marine Biology
Chinese Academy of Fishery Sciences
2003-2025
Zhujiang Hospital
2022-2025
Southern Medical University
2015-2025
Chengdu Third People's Hospital
2024-2025
Chongqing Medical University
2024-2025
Southwest Jiaotong University
2024-2025
Ministry of Agriculture and Rural Affairs
2023-2025
Yunnan University
2024
Xishuangbanna Tropical Botanical Garden
2024
Huazhong Agricultural University
2023-2024
Abstract Precise coordination of cell growth, proliferation and differentiation is essential for the development multicellular organisms. Here, we report that although mechanistic target rapamycin complex 1 (mTORC1) activity required chondrocyte growth proliferation, its inactivation differentiation. Hyperactivation mTORC1 via TSC1 gene deletion in chondrocytes causes uncoupling normal programme within plate, resulting uncontrolled blockage chondrodysplasia mice. Rapamycin promotes restores...
This study aims to identify circulating proteins that are causally associated with osteoarthritis (OA)-related traits through Mendelian randomisation (MR)-based analytical framework.Large-scale two-sample MR was employed estimate the effects of thousands plasma on 12 OA-related traits. Additional analyses including Bayesian colocalisation, Steiger filtering analysis, assessment protein-altering variants and mapping expression quantitative trait loci protein were performed investigate...
<h3>Background</h3> An exogenous supplement of n-3 polyunsaturated fatty acids (PUFAs) has been reported to prevent osteoarthritis (OA) through undefined mechanisms. <h3>Objective</h3> This study investigated the effect alterations in composition endogenous PUFAs on OA, and associations with mammalian target rapamycin complex 1 (mTORC1) signalling, a critical autophagy pathway <i>fat-1</i> transgenic (TG) mice. <h3>Methods</h3> TG wild-type mice were used create an OA model by resecting...
Autophagy maintains cellular homeostasis by stimulating the lysosomal degradation of cytoplasmic structures, including damaged organelles and dysfunctional proteins. The role autophagy in renewal regeneration injured peripheral nerves remains poorly understood. current study investigated nerve motor function recovery following sciatic crush injury rats or suppressing detecting presence autophagosomes LC3-II expression electron microscopy Western blotting, respectively. Neurobehavioral was...
Abstract Monascus pilosus has been used to produce lipid-lowering drugs rich in monacolin K (MK) for a long period. Genome mining reveals there are still many potential genes worth be explored this fungus. Thereby, efficient genetic manipulation tools will greatly accelerate progress. In study, we firstly developed the protocol prepare protoplasts recipient of CRISPR/Cas9 system. Subsequently, vector and donor DNA were co-transformed into recipients (10 6 protoplasts/mL) 60–80 transformants...
Accurately predicting knee osteoarthritis (KOA) is essential for early detection and personalized treatment. We aimed to develop test a magnetic resonance imaging (MRI)-based joint space (JS) radiomic model (RM) predict radiographic KOA incidence through neural networks by integrating meniscus femorotibial cartilage features.
Fungal contamination poses a threat to agriculture, food production and human health, safe effective method limit fungal is still needed. In this study, the inhibitory potency of heptanal, natural volatile chemical, against Aspergillus flavus growth was evaluated, its mechanism action explored. The minimum concentrations (MICs) heptanal vapor fumigation liquid contact culture were 0.085 0.8 μL/mL, respectively. A total 79 significant differentially abundant metabolites, including 37...
The use of a mechanically robust and fast degradable POC-M-click–HA matchstick scaffold resulted in high fusion rates bone strengths rabbit lumbar interbody model.
Abstract: Osteoporosis is a systemic skeletal disease that characterized by low bone density and microarchitectural deterioration of tissue. The increasing prevalence osteoporosis has attracted much attention. In this study, MC3T3-E1 pre-osteoblasts were treated with the natural compound, baicalein (0.1 µmol/L, 1 10 µmol/L), to stimulate differentiation over 14-day period. addition, canonical ovariectomized (OVX) mouse model was used investigate effect 3-month treatment (10 mg/kg per day) in...
The mechanism by which brown adipose tissue (BAT) regulates bone metabolism is unclear. Here, we reveal that BAT secretes S100A8/A9, a previously unidentified adipokine (batokine), to impair formation. Brown adipocytes-specific knockout of
The genus Neobythites is the most diverse group in family Ophidiidae. In this study, we assembled and reported complete mitochondrial genome of N. sivicola for first time. 17,316 bp length contains 13 PCGs, 2 rRNAs, 22 tRNAs. Phylogenetic analysis revealed that was sister species to unimaculatus, closer Sirembo. This study significantly contributes genomic resources available Ophidiidae Neobythites, providing a valuable molecular resource further research on taxonomy phylogenetics family.
Although the reduced muscle quality is common in elderly people, its role development of knee osteoarthritis (OA) remains unclear. Magnetic Resonance Imaging (MRI) considered gold standard imaging modality to assess quality, which might holistically capture underlying pathology. This study aimed apply MRI-based radiomics thigh muscles comprehensively, and examine prediction performance for incident OA. The participants at risk OA during 48-month visit were selected from a multicenter cohort...
In order to understand the diel vertical migration and transport pattern during their early life stages, distribution of larvae juveniles small yellow croaker (Larimichthys polyactis) in Yangtze River estuary was investigated. Four sampling cycles were carried out at station (122°39′ E, 31° N) May June 2015. The samples collected by vertically discrete plankton hauls three strata water column: surface (0~2 m depth), middle (8~10 bottom (18~20 depth). total number 5523, which 65.2% 25.8%...
Dickkopf-1 (DKK-1) has been proved dysfunctional in ankylosing spondylitis (AS), and decreased serum functional DKK-1 levels have identified to be AS patients. This study aims examine the relation of binding (functional) with radiographic severity AS.Total Dkk1 were assessed by commercial sandwich enzyme-linked immunosorbent assay measured using method 84 patients 79 healthy controls. The progression was classified according events modified New York Criteria for sacroiliac joints evaluation...