A5101578705- Heterotopic Ossification and Related Conditions
- Orthopaedic implants and arthroplasty
- Gestational Diabetes Research and Management
- Bone Tissue Engineering Materials
- Spine and Intervertebral Disc Pathology
- Tendon Structure and Treatment
- Magnesium Oxide Properties and Applications
- Concrete and Cement Materials Research
- Maternal Mental Health During Pregnancy and Postpartum
- Bone Metabolism and Diseases
- TGF-β signaling in diseases
- Birth, Development, and Health
- Eating Disorders and Behaviors
- Gout, Hyperuricemia, Uric Acid
- Amoebic Infections and Treatments
- Lipid metabolism and biosynthesis
- Shoulder Injury and Treatment
- Genetic Syndromes and Imprinting
- Pregnancy and preeclampsia studies
- NF-κB Signaling Pathways
- Infectious Diseases and Tuberculosis
- Endometriosis Research and Treatment
- Connective tissue disorders research
- Ion Transport and Channel Regulation
- Asthma and respiratory diseases
Central South University
2024
China University of Petroleum, East China
2024
Second Xiangya Hospital of Central South University
2024
Nanjing University of Information Science and Technology
2024
Guangxi University
2024
Guangxi University of Chinese Medicine
2024
Nanjing Agricultural University
2020-2024
Nanchang University
2024
Third Affiliated Hospital of Southern Medical University
2014-2021
Guangzhou Academy of Fine Arts
2021
Leptin, an adipocyte-derived cytokine associated with bone metabolism, is believed to play a critical role in the pathogenesis of heterotopic ossification (HO). The effect and underlying action mechanism leptin were investigated on osteogenic differentiation tendon-derived stem cells (TDSCs) vitro HO formation rat tendons. Isolated TDSCs treated various concentrations presence or absence mTORC1 signaling specific inhibitor rapamycin vitro. A model Achilles tenotomy was employed evaluate...
The use of a mechanically robust and fast degradable POC-M-click–HA matchstick scaffold resulted in high fusion rates bone strengths rabbit lumbar interbody model.
Abstract: Osteoporosis is a systemic skeletal disease that characterized by low bone density and microarchitectural deterioration of tissue. The increasing prevalence osteoporosis has attracted much attention. In this study, MC3T3-E1 pre-osteoblasts were treated with the natural compound, baicalein (0.1 µmol/L, 1 10 µmol/L), to stimulate differentiation over 14-day period. addition, canonical ovariectomized (OVX) mouse model was used investigate effect 3-month treatment (10 mg/kg per day) in...
Abstract Attempts to replicate native tissue architecture have led the design of biomimetic scaffolds focused on improving functionality. In this study, citrate‐based poly (octanediol citrate)‐click‐hydroxyapatite (POC‐Click‐HA) were developed simultaneously compositional and architectural properties bone while providing immediate structural support for large segmental defects following implantation. Biphasic fabricated with 70% internal phase porosity various external porosities (between 5...
ABSTRACT Despite the regenerative and self‐repair capabilities of bone tissues, significant loss can result in substantial defects. This study was aimed at investigating role underlying mechanisms mechanosensitive protein PDZ LIM Domain 5 (PDLIM5) osteogenic differentiation human adipose‐derived stem cells (hASCs) under cyclic tensile stress conditions relevant to tissue repair. Utilising proteomics single‐cell RNA sequencing, we identified PDLIM5 serpin E2 as key genes associated with...
The development of sepsis is multifactorial. Tissue damage and organ dysfunction may be caused not only by the microorganisms but also inflammatory mediators released in response to infection. Interleukin 6 (IL-6) tumor necrosis factor α (TNF-α) levels serum are well known upregulated humans with can used predict outcome. Using human umbilical vein endothelial cells, we analyzed role guanine-nucleotide exchange H1 (GEF-H1) on lipopolysaccharide (LPS)-dependent IL-6/TNF-α expression cells....
Excessive mechanical loading is a major factor affecting heterotopic ossification (HO), which pathological alteration in calcific tendinopathy. However, physical therapies with as the functional element have exhibited promising results treatment of The dual effects that may on pathogenesis and rehabilitation calcified tendinopathy remain unclear. present study was designed to investigate HO In study, tendon cell vitro stretch model an Achilles tenotomy rat were used simulate different...
Background: Aquaporin (AQP)-1 is expressed in most microvasculature endothelial cells forming water channels that play major roles a variety of physiologic processes. Our aim was to investigate the regulatory functions AQP1 on trancellular and paracellular permeability. Methods: We designed, synthesized, used small interfering RNAs (siRNAs) selective for investigated their effectiveness altering AQP1-mediated permeability human pulmonary microvascular cells. Results: Twenty-four hours after...
Mechanical stress promotes human ligamentum flavum cells (LFCs) to synthesize multitype collagens, leading hypertrophy (LFH). However, the mechanism of mechanical in formation collagen remains unclear. Therefore, we investigated relationship between and synthesis present study. First, LFCs were isolated from 9 patients cultured with or without exposure for different times. IGF-1, I (col-I), III (col-III) protein mRNA levels then detected via ELISA qPCR, respectively. Moreover, activation...
Osteoporosis, which is a systemic skeletal disease characterized by low bone mineral density and microarchitectural deterioration of quality, global increasing public health problem. Recent studies have suggested that Tenuigenin (TEN), class native compounds with numerous biological activities such as anti-resorptive properties, exerts protective effects against postmenopausal loss. The present study aims to investigate the osteogenic TEN on mesenchymal stem cells (BMSCs) in vitro vivo....
This study aims to elucidate the therapeutic potential of osthole for treatment atopic dermatitis (AD), focusing on its ability alleviate chronic pruritus (CP) and underlying molecular mechanisms. In this study, we investigated anti-inflammatory effects in both a 2,4-dichloronitrobenzene (DNCB)-induced AD mouse model tumor necrosis factor-α (TNF-α) interferon-γ (IFN-γ) stimulated huma immortalized epidermal (HaCaT) cells. The anti-itch effect was specifically assessed model. Using methods...
The type of activator has a significant impact on the performance alkali-activated slag, and there is little research effect high-temperature slag. effects thickening time, compressive strength, rheological properties slag under condition were studied in this article. Six activators designed using Ca(OH)2, Na2CO3, Na2SO4 their combination. results show that are obvious differences for with different activators. In addition, AAM at elevated temperatures distinct from observed room...
Congenital spinal deformity is the most severe clinical orthopedic issue worldwide. Among all pathological processes of congenital deformity, imbalance endochondral ossification considered to be important developmental cause dysplasia. We established chondrocyte-specific TSC-1 knockout (KO) mice overactivate energy metabolic component, mammalian target rapamycin complex 1 (mTORC1), and measured development by general, imaging, histological, Western-blot assessments. In addition skeletal...
Significant progress in artificial bone grafts has been achieved recent years. However, none of them osteogenic ability that is close to autogenous bones. Hence, improving the most prominent and challenging task this field. In addition, angiogenesis could provide a stable environment nutrients for survival cells also plays crucial role success transplantation. present study, we combined citrate polymer bioactive glass together as hybrids at molecular level (PEC-GS/BG), with expectation...
Although heterotopic ossification (HO) has been reported to be a common complication of the posttraumatic healing process, underlying mechanism remains unknown. Endothelial-mesenchymal transition (EndMT) is known play role in HO, and our recent study observed that neuroendocrine signals can promote HO by modulating EndMT. Melatonin, hormone secreted mainly pineal gland, documented perform its function skeletal system. This aimed at describing expression melatonin during formation rat models...
The utilization of Quantum dots (QDs) in the construction phototransistors presents a highly promising avenue for development responsive sensors, which are compatible with wide range gas-sensing systems. However, it is worth noting that currently prevalent QDs-based suffer from certain limitations, such as extended recovery time, elevated dark current, and reduced sensing area. These drawbacks significantly impede their effectiveness dynamic laser domain. In this study, we present novel...
<title>Abstract</title> Background Excessive gestational weight gain is a global public health problem with serious and long-term effects on maternal offspring health. Early identification of at-risk groups interventions crucial for controlling reducing the incidence excessive gain. Currently, tools predicting risk are lacking in China. This study aimed to develop risk-prediction model screening tool early groups. Methods Convenience sampling was used select 306 pregnant women who underwent...
Background Excessive Gestational Weight Gain is a global public health problem with serious and long-term effects on maternal offspring health. Early identification of at-risk groups interventions crucial for controlling weight gain reducing the prevalence excessive gestational gain. Currently, tools predicting risk are lacking in China. This study aimed to develop risk-prediction model screening tool identify high-risk early stages.