A5081534463- Autophagy in Disease and Therapy
- NF-κB Signaling Pathways
- Tendon Structure and Treatment
- Signaling Pathways in Disease
- interferon and immune responses
- RNA Research and Splicing
- Cancer-related gene regulation
- Hippo pathway signaling and YAP/TAZ
- Heterotopic Ossification and Related Conditions
- Bone Metabolism and Diseases
- RNA modifications and cancer
- Shoulder Injury and Treatment
- Inflammasome and immune disorders
- TGF-β signaling in diseases
- Spine and Intervertebral Disc Pathology
- Osteoarthritis Treatment and Mechanisms
- Laser Applications in Dentistry and Medicine
- Sports injuries and prevention
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Bone health and osteoporosis research
- Natural product bioactivities and synthesis
- Gallbladder and Bile Duct Disorders
- Toxoplasma gondii Research Studies
- Esophageal and GI Pathology
Yue Bei People's Hospital
2017-2025
Jiangsu University
2014-2025
Southern Medical University
2019-2025
Shantou University
2017-2025
Shantou University Medical College
2020-2025
Third Affiliated Hospital of Southern Medical University
2016-2024
Guangdong Academy of Medical Sciences
2017-2024
Texas A&M University
2024
Southern University of Science and Technology
2024
Broad Institute
2024
Macroautophagy/autophagy plays an important role in regulating cellular homeostasis and influences the pathogenesis of degenerative diseases. Tendinopathy is characterized by tendon degeneration inflammation. However, little known about selective autophagy tendinopathy. Here, we find that pristimerin (PM), a quinone methide triterpenoid, more effective treating tendinopathy than first-line drug indomethacin. PM inhibits AIM2 inflammasome alleviates inflammation during promoting autophagic...
Inflammatory bowel disease (IBD) is a chronic and potentially life-threatening inflammatory of gastroenteric tissue characterized by episodes intestinal inflammation, but the underlying mechanisms remain elusive. Here, we explore role precise mechanism Van-Gogh-like 2 (VANGL2) during pathogenesis IBD. VANGL2 decreases in IBD patients dextran sulfate sodium (DSS)-induced colitis mice. Myeloid deficiency exacerbates progression DSS-induced mice specifically enhances activation NLRP3...
Stringent control of type I interferon (IFN-I) signaling is critical to potent innate immune responses against viral infection, yet the underlying molecular mechanisms are still elusive. Here, we found that Van Gogh–like 2 (VANGL2) acts as an IFN-inducible negative feedback regulator suppress IFN-I during vesicular stomatitis virus (VSV) infection. Mechanistically, VANGL2 interacted with TBK1 and promoted selective autophagic degradation via K48-linked polyubiquitination at Lys 372 by E3...
Leptin, an adipocyte-derived cytokine associated with bone metabolism, is believed to play a critical role in the pathogenesis of heterotopic ossification (HO). The effect and underlying action mechanism leptin were investigated on osteogenic differentiation tendon-derived stem cells (TDSCs) vitro HO formation rat tendons. Isolated TDSCs treated various concentrations presence or absence mTORC1 signaling specific inhibitor rapamycin vitro. A model Achilles tenotomy was employed evaluate...
Tendinopathy is mainly characterized by local pain, functional limitation and decreased athletic ability, which seriously affects the quality of life patients career athletes. Farrerol (FA), one main active compounds extracted from Rhododendron plants in family, has a wide range pharmacological activities, such as immunomodulatory, anti-inflammatory antiviral effects. However, effect FA on tendinopathy unclear. Here, we investigated mechanism tendon injury through collagenase-induced vivo...
With the development of an aging population, tendinopathy has become a common musculoskeletal disease in elderly with high recurrence rate and no curative treatment. The inflammation mediated by NF-κB signaling plays important role tendon senescence degeneration. Friedelin (FR) is triterpenoid derived from green plants, which variety pharmacological functions, such as analgesia, anti-inflammation, antioxidation, anti-tumor functions. However, mechanism FR are unclear. Here, we found that...
The pathogenesis of trauma-induced heterotopic ossification (HO) in the tendon remains unclear, posing a challenging hurdle treatment. Recognizing inflammation as root cause HO, anti-inflammatory agents hold promise for its management. Malvidin (MA), possessing properties, emerges potential agent to impede HO progression. This study aimed investigate effect MA treating and unravel underlying mechanisms. Herein, effectiveness preventing formation was assessed through local injection rat...
Abstract This paper aims to probe into the effect of sweroside (SOS) in osteoporosis (OP) and explains mechanisms its molecular. Applying ovariectomized (OVX) mouse model investigates preventive SOS against postmenopausal OP after 3 months treatment (120 mg/kg/day). Using hematoxylin eosin (HE) staining micro computed tomography (CT) observed morphology each group. Immunohistochemical (IHC) was used examine osteoblast markers. Experiments vitro, bone marrow mesenchymal stem cells (BMSCs)...
Abstract Osteoporosis is characterized by increased bone fragility, and the drugs used at present to treat osteoporosis can cause adverse reactions. Gentiopicroside (GEN), a class of natural compounds with numerous biological activities such as anti‐resorptive properties protective effects against loss. Therefore, aim this work was explore effect GEN on mesenchymal stem cells (BMSCs) osteogenesis for potential therapy. In vitro, BMSCs were exposed different doses 2 weeks, whereas in vivo,...
Innate immunity acts as the first line of defense against pathogen invasion. During Toxoplasma gondii infection, multiple innate immune sensors are activated by invading microbes or pathogen-associated molecular patterns (PAMPs). However, how inflammasome is and its regulatory mechanisms during T. infection remain elusive. Here, we showed that PRU, a lethal type II strain, activates at early stage infection. PRU tachyzoites, RNA soluble tachyzoite antigen (STAg) mainly triggered NLRP3...
Abstract Synovial macrophage polarization and inflammation are essential for osteoarthritis (OA) development, yet the molecular mechanisms regulation responsible pathogenesis still poorly understood. Here, we report that pseudolaric acid B (PAB) attenuated articular cartilage degeneration synovitis during OA. PAB, a diterpene acid, specifically inhibited NF‐κB signalling reduced production of pro‐inflammatory cytokines, which further decreased M1 vessel formation. We provide in vivo vitro...
Osteoarthritis (OA) is the most common disease of joints, and characterized by breakdown cartilage degradation extracellular matrix. OA causes a high level patient suffering incurs large societal costs; however, current strategies for treating are restricted due to limited understanding underlying molecular cellular mechanisms. In present study, beneficial effects isoimperatorin (Iso) were investigated using an experimental mouse model OA, its mechanism action on primary chondrocytes was...
Excessive mechanical loading is a major factor affecting heterotopic ossification (HO), which pathological alteration in calcific tendinopathy. However, physical therapies with as the functional element have exhibited promising results treatment of The dual effects that may on pathogenesis and rehabilitation calcified tendinopathy remain unclear. present study was designed to investigate HO In study, tendon cell vitro stretch model an Achilles tenotomy rat were used simulate different...
Background. The relationship between H. pylori infection and gastric cancer (GC) has been widely studied, is considered as the main factor. Utilizing bioinformatics analysis, this study examined gene signatures related to progressing pylori-associated GC. Materials Methods. dataset GSE13195 was chosen search for abnormally expressed genes in GC normal tissues. TCGA-STAD database verify expression of key Results. In GSE13195, a total 332 differential (DEGs) were screened. results weighted...
Van Gogh-like 2 (Vangl2), a core planar cell polarity component, plays an important role in polarized cellular and tissue morphology induction, growth development, cancer. However, its regulating inflammatory responses remains elusive. Here, we report that Vangl2 is upregulated patients with sepsis identify as negative regulator of The nuclear factor-kappaB (NF-κB) signaling by the protein stability activation transcription component p65. Mice myeloid-specific deletion ( ΔM ) are...
Tendon-bone healing is a reconstructive procedure which requires tendon graft to bone tunnel or the surface of after junction injury between tendon, ligament, and bone. The surgical reattachment often fails due regeneration failure specialized tendon-bone junction.An extra-articular rat model was established discuss effect baicalein 10 mg/(kg·d) in accelerating progress. Also, tendon-derived stem cells (TDSCs) were treated with various concentrations dickkopf-1 (DKK-1) stimulate...
Narrowing of the lumbar spinal canal is a condition called stenosis (LSS) and high-morbidity problem in elderly. LSS commonly caused by hypertrophy ligamentum flavum (HLF). Previous studies showed that fibrosis (LF) largely contributed to HLF. However, underlying pathomechanism remains unclear. Insulin-like growth factor-1 (IGF-1) known have an intimate relationship with various tissues. Nevertheless, currently, there are few regarding IGF-1 In this study, we investigated role HLF its...
Bone fracture is a global healthcare issue for high rates of delayed healing and nonunions. Although n-3 polyunsaturated fatty acid (PUFA) considered as beneficial factor bone metabolism, only few studies till date focused on the effects PUFAs healing. In this study, we investigated effect endogenous by measuring femur repair in both fat-1 transgenic mice WT mice. Proximal femoral model was established mice, respectively, then analyzed using X-ray, micro-computed tomography (micro-CT),...
ABSTRACT Stringent control of the type I interferon (IFN-I) signaling is critical for host immune defense against infectious diseases, yet molecular mechanisms that regulate this pathway remain elusive. Here, we show Src homology 2 containing inositol phosphatase 1 (SHIP1) suppresses IFN-I by promoting IRF3 degradation during malaria infection. Genetic ablation Ship1 in mice leads to high levels and confers resistance Plasmodium yoelii nigeriensis ( P.y. ) N67 Mechanistically, SHIP1 promotes...
Currently, there are no specific drugs or targets available for the treatment of tendinopathy. However, inflammation has recently been found to play a pivotal role in tendinopathy progression, thereby identifying it as potential therapeutic target. Carpaine (CA) exhibits anti-inflammatory pharmacological properties and may offer option
Osteoporosis, which is a systemic skeletal disease characterized by low bone mineral density and microarchitectural deterioration of quality, global increasing public health problem. Recent studies have suggested that Tenuigenin (TEN), class native compounds with numerous biological activities such as anti-resorptive properties, exerts protective effects against postmenopausal loss. The present study aims to investigate the osteogenic TEN on mesenchymal stem cells (BMSCs) in vitro vivo....