A5101543483- Carbohydrate Chemistry and Synthesis
- Protein Tyrosine Phosphatases
- Advanced biosensing and bioanalysis techniques
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Lipid Membrane Structure and Behavior
- Supramolecular Self-Assembly in Materials
- Molecular Sensors and Ion Detection
- Biosensors and Analytical Detection
- Curcumin's Biomedical Applications
- Genetic Associations and Epidemiology
- Click Chemistry and Applications
- Electrochemical sensors and biosensors
- RNA modifications and cancer
- Geophysical Methods and Applications
- PI3K/AKT/mTOR signaling in cancer
- Groundwater flow and contamination studies
- Luminescence and Fluorescent Materials
- Sulfur Compounds in Biology
- Energy, Environment, Economic Growth
- Sustainable Finance and Green Bonds
- Biochemical and Molecular Research
- Statistical Methods and Inference
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
Wenzhou Medical University
2017-2024
First Affiliated Hospital of Fujian Medical University
2023-2024
Fujian Medical University
2023-2024
Guangdong Academy of Agricultural Sciences
2024
Rice Research Institute
2024
Quzhou University
2023-2024
Beijing Forestry University
2019-2023
Xiamen University
2023
East China University of Science and Technology
2007-2021
Nobel Foundation
2020
A galatosyl azidonaphthalimide probe is developed for the selective, fluorogenic imaging of hepatocellular H<sub>2</sub>S.
The present study was designed to examine the damage caused by high-fat diet and streptozotocin-induced diabetes on testis of rats effects curcumin against oxidative stress apoptosis from diabetes.Diabetes induced intraperitoneal injection streptozotocin (30 mg/kg in 0.1 M sodium citrate buffer, pH 4.5) obese rats. diabetic groups were treated with a daily dose intragastric intubation (100 body weight) for 8 weeks. Testis tissue sections stained hematoxylin-eosin, identified situ using...
Recent progress in quantum dot (QD) based chemo- and biosensors for various applications is summarized.
Carbohydrates represent one of the most significant natural building blocks, which govern numerous critical biological and pathological processes through specific carbohydrate−receptor interactions on cell surface. We present here a new class electrochemical probes based gold surface-coated epimeric monosaccharide−quinone hybrids toward ingenious detection carbohydrate−protein interactions. Glucose galactose, pair monosaccharide C4 epimers, were used to closely solidly conjugate with...
We report a general strategy for the fluorogenic sensing of glycosidases in cells based on aggregation-induced emission glycoclusters.
We have developed a novel class of simple materials for sensing monosaccharides by the functionalization graphene oxide (GO) with boronate-based fluorescence probes (BA1 and BA2). The composite were characterized atomic force microscopy, Raman spectroscopy, UV-vis/fluorescence spectroscopy. strong BA is quenched in presence GO through resonance energy transfer. BA@GO sensors formed provide useful platform fluorogenic detection based on affinity between boronic acid receptor monosaccharides....
This study describes the exploitation of click chemistry in one-step molecular engineering an unqualified rhodamine probe, leading to its considerable functional enhancement terms water solubility, ion selectivity, and usefulness detecting biological environmental samples. A dipropargyl dye previously identified as unselective poorly water-soluble mercury(II) probe was used couple with azido polyethylene glycol (PEG) by Cu(I)-catalyzed azide–alkyne 1,3-dipolar cycloaddition reaction almost...
Ligand–protein interactions (LPIs) are fundamental biological processes that manipulate a variety of cellular events. While multiple LPIs can occur concurrently or concertedly at interface, techniques which able to simultaneously probe these diverse remain challenging. Here, the best our knowledge, first fluorogenic composite material (FCM) is developed single biomimetic interface. We determined two glycoligands coupled with fluorescence dyes different emission colors coassemble graphene...
The mechanisms underlying lipid metabolic disorders in Parkinson's diseases (PD) remain unclear. Weighted Gene Co-Expression Network Analysis (WGCNA) was conducted to identify PD-related modular genes and differentially expressed (DEGs). Lipid metabolism-related (LMRGs) were extracted from Molecular Signatures Database. Candidate assessed with overlapping genes, DEGs, LMRGs for the purpose of building protein–protein interaction (PPI) networks. Then, biomarkers generated by machine learning...
Intercellular ligand-receptor recognitions are crucial natural interactions that initiate a number of biological and pathological events. We present here the simple construction unique class biomimetic interfaces based on graphene-mediated self-assembly glycosyl anthraquinones to screen-printed electrode for detection transmembrane glycoprotein receptors expressed hepatoma cell line. show an electroactive interface confined with densely clustered galactosyl ligands is able ingeniously...
Here, we describe a novel "switch-on" biosensor based on quinonyl glycosides functionalized quantum dots (QDs) for the specific targeting and imaging of transmembrane glycoprotein receptors surface cancer cells. The design lies in that quinone moiety serves as quencher QDs glycoside biospecific ligand receptor. We observed quenched photoluminescence could be significantly recovered by lectin selectively binds to clustering but was not affected panel nonspecific lectins. Moreover, determined...
Abstract Biological tissues grow or evolve through a series of complicated processes matter and energy internalization, which are highly challenging to mimic in synthetic materials. Herein, delayed cross‐linking strategy is developed program the reactivity sites make hydrogels evolvable. The polymer networks constructed by combining polyvinyl alcohol (PVA) with polyzwitterion comprising both cationic quaternary ammonium anionic phenylboronic acid groups (PQBA). Shielding ion pairs...
Fluorogenic supramolecular complexes formed between tubular-shaped pyrenyl-β-cyclodextrins and glyco-rhodamine are determined to respond a selective lectin with 'turn-on' fluorescence excellent selectivity over range of competing species.
Objectives: To investigate the expression and clinical significance of Sonic hedgehog (Shh) in pancreatic adenocarcinoma. Methods: The Shh protein was examined 34 surgical specimens primary adenocarcinoma, 21 nonmalignant pancreas by immunohistochemistry streptavidin-perosidase (SP) method. In addition, semiquantitative reverse transcriptase polymerase chain reaction carried out to analyze mRNA 22 pairs freshly resected adenocarcinoma tissues their adjacent nontumorous tissues. Results:...