A5040791582- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Diet, Metabolism, and Disease
- Gut microbiota and health
- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- RNA Interference and Gene Delivery
- Liver Disease Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Enterobacteriaceae and Cronobacter Research
- FOXO transcription factor regulation
- Anesthesia and Pain Management
- Cytomegalovirus and herpesvirus research
- Glycosylation and Glycoproteins Research
- Biochemical and Molecular Research
- Cellular transport and secretion
- Cancer therapeutics and mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Diet and metabolism studies
- CAR-T cell therapy research
- Advanced biosensing and bioanalysis techniques
- Metabolism, Diabetes, and Cancer
- Immune Cell Function and Interaction
- Peptidase Inhibition and Analysis
- Pancreatic function and diabetes
Chongqing Medical University
2024-2025
Children's Hospital of Chongqing Medical University
2024-2025
Chinese Academy of Sciences
2011-2024
Hunan Provincial Center for Disease Control and Prevention
2024
Sichuan University
2022
University of Chinese Academy of Sciences
2019-2020
Institute of Biophysics
2020
Wuhan Institute of Virology
2017-2020
The University of Texas Southwestern Medical Center
2020
Shanghai Institute of Materia Medica
2014
Abstract While IL-2 can potently activate both NK and T cells, its short in vivo half-life, severe toxicity, propensity to amplify Treg cells are major barriers that prevent from being widely used for cancer therapy. In this study, we construct a recombinant immunocytokine comprising tumor-targeting antibody (Ab) super mutant (sumIL-2) with decreased CD25 binding increased CD122 binding. The Ab-sumIL2 significantly enhances antitumor activity through tumor targeting specific cytotoxic...
The lack of sufficient functional tumor-infiltrating lymphocytes in the tumor microenvironment (TME) is one primary indications for poor prognosis patients with cancer. In this study, we developed an Erbitux-based IL-21 tumor-targeting fusion protein (Erb-IL21) to prolong half-life and improve antitumor efficacy IL-21. Compared Erb-IL2, Erb-IL21 demonstrated much lower toxicity vivo. Mechanistically, selectively expanded cytotoxic T but not dysfunctional CD8+ cells TME. We observed that...
Intercellular ligand-receptor recognitions are crucial natural interactions that initiate a number of biological and pathological events. We present here the simple construction unique class biomimetic interfaces based on graphene-mediated self-assembly glycosyl anthraquinones to screen-printed electrode for detection transmembrane glycoprotein receptors expressed hepatoma cell line. show an electroactive interface confined with densely clustered galactosyl ligands is able ingeniously...
Prospective trial evidence is lacking regarding the application of enhanced recovery after surgery (ERAS) in transvaginal pelvic floor reconstruction among older patients. Our study aimed to investigate whether implementing ERAS protocol could enhance post-operative this patient population. Older patients undergoing elective were randomly assigned either group or conventional group. The primary outcome was length stay (LOS). secondary outcomes encompassed other metrics, pain within 30 days,...
HCV infection can decrease NAD+/NADH ratio, which could convert lipid metabolism to favor replication. In hepatocytes, quinolinate phosphoribosyl transferase (QPRT) catabolizes quinolinic acid (QA) nicotinic mononucleotide (NAMN) for de novo NAD synthesis. However, whether and how modulates QPRT hence the lipogenesis is unknown. this work, we found was reduced significantly in livers of patients or humanized C/OTg mice with persistent infection. Mechanistic studies indicated that NS3/4A...
BackgroundDaytime hysteroscopy requires anesthesia that offers rapid onset and clearance, with minimal respiratory cardiovascular suppression. This study compared the effects of different doses alfentanil combined propofol target-controlled infusion (TCI) for such procedures.MethodsWe randomized 240 patients undergoing daytime into three groups to receive at 5 μg/kg, 10 15 TCI. We meticulously recorded complications perioperative vitals evaluate safety efficacy each dosage regimen.ResultsThe...
To explore the protective effects of live or pasteurized Akkermansia muciniphila and Amuc_1100 protein on a rat model diabetes mellitus induced by high-fat diet (HFD) combined with streptozotocin (STZ).A total 96 Sprague-Dawley (SD) rats were randomly assigned to 8 groups, including 6 experimental groups 2 control 12 in each group. HFD STZ injection was given create simulated progression type 2. In addition, treated different doses way gavage for weeks simultaneously. Plasma samples...
Abstract Of dietary monosaccharides, fructose is primarily metabolized by aldolase B (ALDOB) in the liver, whereas glucose elsewhere body. It has been documented that overconsumption of fructose, especially industrial associates significantly with advanced inflammation chronic hepatitis C (CHC) patients. However, little known about whether impaired fructolysis might attribute to CHC hepatopathogenesis. Herein we found level ALDOB protein was reduced patients and mice were persistently...
Numerous studies have demonstrated that