A5067710140- Neuroinflammation and Neurodegeneration Mechanisms
- Medical Imaging and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Neuroscience and Neuropharmacology Research
- Diffusion Coefficients in Liquids
- Phase Equilibria and Thermodynamics
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- Adsorption, diffusion, and thermodynamic properties of materials
- Adsorption and biosorption for pollutant removal
- Ionic liquids properties and applications
- Gestational Diabetes Research and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Birth, Development, and Health
- Pharmacological Effects of Natural Compounds
- Diet, Metabolism, and Disease
- Electrocatalysts for Energy Conversion
- Inflammasome and immune disorders
- MRI in cancer diagnosis
- MicroRNA in disease regulation
- Advanced Technologies and Applied Computing
- Mechanical Failure Analysis and Simulation
- Medicinal Plants and Neuroprotection
- Metal Alloys Wear and Properties
- Single-cell and spatial transcriptomics
Children's Hospital of Zhejiang University
2019-2025
Beijing Institute of Aeronautical Materials
2024
Ningbo University of Technology
2015-2024
Zhongnan University of Economics and Law
2023
Sichuan University
2020-2022
Hebei Provincial Center for Disease Control and Prevention
2022
Peking University
2021
Zhejiang University
2005-2020
Ministry of Education of the People's Republic of China
2017
Qinghai University
2008-2011
Abstract Accumulating evidence suggests a role of bisphenol A (BPA) in metabolic disorders. However, the underlying mechanism is still unclear. Using mouse BPA exposure model, we investigated effects long-term on lipid metabolism and mechanisms. The male mice exposed to (0.5 μg /kg/day, human relevant dose) for 10 months exhibited significant hepatic accumulation triglycerides cholesterol. liver cells from BPA-exposed showed significantly increased expression levels genes related synthesis....
Abstract Evidence from experimental and clinical studies implicates immuno-inflammatory responses as playing an important role in epilepsy-induced brain injury. Captopril, angiotensin-converting enzyme inhibitor (ACEi), has previously been shown to suppress a variety of neurological diseases. However, the therapeutic potential captopril on epilepsy remains unclear. In present study, Sprague Dawley (SD) rats were intraperitoneally subjected kainic acid (KA) establish status epilepticus....
Tetraethylenepentamine-functionalized core–shell structured nanomagnetic Fe<sub>3</sub>O<sub>4</sub> polymers (TEPA-Fe<sub>3</sub>O<sub>4</sub>-NMPs) with different amounts of magnetic core were synthesized and fully characterized. The might favor mass transfer accelerating the adsorption process.
Multiple sclerosis (MS) is a disease of the central nervous system (CNS) that characterized by demyelination, axonal injury and neurological deterioration. Few medications are available for progressive MS, which associated with neuroinflammation confined to CNS compartment. Transient receptor potential melastatin 2 (TRPM2) calcium-permeable, non-selective cation channel plays pathological roles in wide range neuroinflammatory diseases; however, underlying molecular mechanisms TRPM2 remain...
Abstract Background A consensus has formed that neural circuits in the brain underlie pathogenesis of temporal lobe epilepsy (TLE). In particular, synaptic excitation/inhibition balance (E/I balance) been implicated shifting towards elevated excitation during development TLE. Methods Sprague Dawley (SD) rats were intraperitoneally subjected to kainic acid (KA) generate a model Next, electroencephalography (EEG) recording was applied verify stability and detectability spontaneous recurrent...
Spinal diseases are killers that cause long-term disturbance to people with complex and diverse symptoms may other conditions. At present, the diagnosis treatment of main mainly depend on professional level clinical experience doctors, which is a breakthrough problem in field medicine. This article proposes SMOTE-RFE-XGBoost model, takes physical angle human bone as research index for feature selection classification model construction predict spinal diseases. The process follows: two groups...
The existing reports about intergenerational or transgenerational effects of intrauterine hyperglycemia have included both and postnatal metabolic exposure factors, while the impact per se has not been assessed alone. A number studies suggest DNA methylation reprogramming gametes plays a crucial role in inheritance, but it is unclear when how patterns are altered exposed to hyperglycemia. In this study, we selected nondiabetic F1- F2-gestational diabetes mellitus (GDM) male mice as founders...
Abstract Spatial decoupling of light absorption and catalytic reaction is a promising approach to improve the efficiency stability Si photoelectrodes. Herein, patterned Ag dots (PADs) are fabricated as front electrode on glass layer commercial SiN x ‐coated monocrystalline p‐n + by an industrial manufacture strategy. It found that electron tunneling offers excellent protection photocathode in acidic electrolyte (0.5 M H 2 SO 4 ). The for antireflection surface passivation also resists...
Epilepsy is one of the most common neurological disorders. Neuroinflammation involving activation microglia and astrocytes constitutes an important mechanism in epileptogenesis. Transient receptor potential melastatin 2 (TRPM2) a calcium-permeable, non-selective cation channel that plays pathological roles various inflammation-related diseases. Our previous study demonstrated Trpm2 knockout exhibits therapeutic effects on pilocarpine-induced glial neuroinflammation. However, whether TRPM2...
Rationale: The hyperactivity of lateral habenula (LHb) has been implicated in the pathophysiology depression, but regulatory mechanisms inhibitory synapses this context remains unclear. MDGA1 and neuroligin2 (Nlgn2), both regulators synapses, selectively interact LHb. We aimed to investigate if their interaction contributes chronic restrained stress (CRS)-induced depression by modulating synapses. Methods: Transgenic mouse models were established conditional knockout/recover expression or...
Monkey disease models, which are comparable to humans in terms of genetic, anatomical, and physiological characteristics, important for understanding mechanisms evaluating the efficiency biological treatments. Here, we established an A.suum-induced model asthma cynomolgus monkeys profile airway inflammation remodeling lungs by single-cell RNA sequencing (scRNA-seq). The results hyperresponsiveness remodeling, demonstrated pulmonary function test histological characterization. scRNA-seq...
In this work, we examine the theoretical performance of perturbed-chain statistical associating fluid theory based density functional (DFT) in predicting gas adsorption and separation metal–organic frameworks by using simulation experimental data as benchmark. Adsorption isotherms methane ethane pure mixtures selectivities for ethane/methane are calculated. The predicted DFT excellent agreement with ethane, whereas mixture, is semi-quantitative accordance results. For fast high-throughput...