A5101596984- MicroRNA in disease regulation
- T-cell and B-cell Immunology
- PI3K/AKT/mTOR signaling in cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Topology Optimization in Engineering
- RNA modifications and cancer
- Animal Genetics and Reproduction
- Composite Structure Analysis and Optimization
- Multiple Myeloma Research and Treatments
- Ferroptosis and cancer prognosis
- Cannabis and Cannabinoid Research
- Galectins and Cancer Biology
- Neurobiology and Insect Physiology Research
- Advanced Multi-Objective Optimization Algorithms
- High Altitude and Hypoxia
- Biochemical and Molecular Research
- Proteoglycans and glycosaminoglycans research
- Advanced biosensing and bioanalysis techniques
- Liver physiology and pathology
- Cancer Mechanisms and Therapy
- Transgenic Plants and Applications
- Mast cells and histamine
- Protein Degradation and Inhibitors
The First Affiliated Hospital, Sun Yat-sen University
2024-2025
Sun Yat-sen University
2024-2025
Shanghai Traditional Chinese Medicine Hospital
2024
Northwestern Polytechnical University
2010-2021
Zhengzhou University
2011-2020
Shuguang Hospital
2019
Shanghai University of Traditional Chinese Medicine
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
Wuhan Institute of Virology
2017
Chinese Academy of Sciences
2017
The drugs lenalidomide and pomalidomide bind to the protein cereblon, directing CRL4–CRBN E3 ligase toward transcription factors Ikaros Aiolos cause their ubiquitination degradation. Here we describe CC-220 (compound 6), a cereblon modulator in clinical development for systemic lupus erythematosis relapsed/refractory multiple myeloma. Compound 6 binds with higher affinity than or pomalidomide. Consistent this, cellular degradation of is more potent extent substrate depletion greater. crystal...
Introduction Triple-negative breast cancer (TNBC) is the most malignant type of cancer, and its prognosis still worst. It necessary to constantly explore pathogenesis effective therapeutic targets TNBC. Formononetin an active ingredient with anti-tumor effects that we screened earlier. The main purpose this study elucidate mechanism inhibitory effect on Methods We conducted experiments through both in vivo vitro methodologies. utilized a nude mice xenotransplantation model, while...
Lung alveolar epithelial cells are exposed to hypoxia under a variety of physiological and pathological conditions. It has been shown recently that miR-143, which can directly target the key glycolytic enzyme hexokinase II (HK2), may be regulated by miR-155. We investigated whether microRNAs contribute cellular glycolysis in response hypoxia. Using A549 cells, we found expression Dicer is decreased When was knocked down with small-interfering RNA (siRNA), pre-miR143 increased mature miR-143...
The bone size and quality, acquired during adolescent growth under the influence of anabolic hormones, factors, nutrients, determine height stability forecast osteoporosis risks in late life. Yet quality control mechanisms remain enigmatic. To study roles mammalian target rapamycin (mTOR) signaling, sensor factors regulation, we ablated Tsc1, a suppressor mTOR, mesenchymal stromal cells (MSCs), monocytes, or their progenies osteoblasts osteoclasts. mTOR activation MSCs, but much less...
3539 Background: For patients with colorectal liver metastasis (CRLM) who have failed in first-line or second-line systemic treatment, the prognosis is extremely poor. Regorafenib standard third line treatment regimen. We aim to explore safety and clinical efficacy of added drug eluting beads loaded irinotecan (DEBIRI) plus hepatic arterial infusion chemotherapy (HAIC) regorafenib combination above CRLM. Methods: this single-center, single-arm, prospective, phase II trial, unresectable...
e16245 Background: Transarterial chemoembolization (TACE) can effectively reduce tumor burden by delivering chemotherapy drugs directly to the while simultaneously blocking its blood supply. Donafenib, a novel multi-kinase inhibitor, showed promise in inhibiting growth and angiogenesis. Combining TACE with donafenib may enhance local systemic control of unresectable hepatocellular carcinoma (uHCC). This study aimed evaluate efficacy safety combined for uHCC patients real-world setting....
Background. Formononetin, an active ingredient isolated from the traditional Chinese medicinal herb Astragalus membranaceus , has anticancer and chemoresistance-reducing biological activities. We evaluated efficacy of formononetin in improving tumoricidal effect everolimus by suppressing mTOR pathway breast cancer cells. Methods. Cell survival was assessed using MTT assay. Apoptosis detected flow cytometry. Proteins related to were real-time PCR Western blot analysis . Results. The results...
HCV infection can decrease NAD+/NADH ratio, which could convert lipid metabolism to favor replication. In hepatocytes, quinolinate phosphoribosyl transferase (QPRT) catabolizes quinolinic acid (QA) nicotinic mononucleotide (NAMN) for de novo NAD synthesis. However, whether and how modulates QPRT hence the lipogenesis is unknown. this work, we found was reduced significantly in livers of patients or humanized C/OTg mice with persistent infection. Mechanistic studies indicated that NS3/4A...
Background: Cytokine-induced killer cells (CIKs) are nonspecific antitumor effectors with superior advantages. CD4+ CIKs can induce Fas-dependent apoptosis in sensitive Raji cells. Here, a was detected resistant breast cancer MDA-MB-231 cells, and underlying mechanisms were discriminated. Methods: Amplification of purification performed 15 patients malignant solid tumors. The expression CD40L soluble cytokines analyzed. apoptotic rates tumor the Fas on membranes using flow cytometry assay....
Background: Ductal carcinoma in situ of the breast constitutes early stage cancer when cells are confined by intact myoepithelial cell layer. Transition from DCIS to invasive is a process yet poorly understood. Mate
e16145 Background: To evaluate the efficacy and safety of TACE combined with Donafenib, which is as a new tyrosine kinase inhibitors therapy recommended by China liver cancer staging (CNLC) system for treatment unresectable hepatocellular carcinoma (uHCC). Methods: We conducted single-center, retrospective study on patients diagnosed uHCC treated plus Donafenib first-line between May 2021 September 2023 at The First Affiliated Hospital Sun Yat-sen University. primary outcomes evaluated in...
Objective To research the protective effects of heme oxygenase-1 (HO-1) on ALI rats,the influence HO-1 expression aquaporin-1 (AQP-1) and AQP-5 in lung tissue, possible mechanism. Methods Thirty Wistar rats were randomly divided into three groups:normal saline treated group,ALI model group,and hemin induced group.The observed for four hours after injecting lipopolysaccharide tail vein,the optical microscope was used to observe pathological changes tissue,wet/dry ratio tissue measured,...
Structural optimization is of great importance to improve the static and dynamic performances, particularly in industrial equipments working under loads simultaneously, like airplane, steamship automobile. In this paper, we study pseudo-density based topology load white-noise excitation. The mean square responses designated locations total strain energy are assigned as two kinds design constraints while structural weight considered objective function be minimized. material properties...