A5021762729- Paleontology and Stratigraphy of Fossils
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Plant responses to elevated CO2
- Hepatitis B Virus Studies
- Geology and Paleoclimatology Research
- CRISPR and Genetic Engineering
- Atmospheric chemistry and aerosols
- Isotope Analysis in Ecology
- Immunotherapy and Immune Responses
- Respiratory viral infections research
- Hepatitis C virus research
- COVID-19 Impact on Reproduction
- CAR-T cell therapy research
- Immune responses and vaccinations
- Viral gastroenteritis research and epidemiology
- Viral Infectious Diseases and Gene Expression in Insects
- Sustainable Finance and Green Bonds
- Hepatitis Viruses Studies and Epidemiology
- Market Dynamics and Volatility
- Animal Virus Infections Studies
- Geological formations and processes
- Healthcare Systems and Reforms
- Credit Risk and Financial Regulations
- Immune Cell Function and Interaction
Xiamen University
2020-2024
Nanjing University of Information Science and Technology
2021-2024
Northwest University
2024
Northwest University
2024
State Key Laboratory of Continental Dynamics
2024
China University of Petroleum, Beijing
2023
Abstract Identifying new lead molecules to treat cancer requires more than a decade of dedicated effort. Before selected drug candidates are used in the clinic, their anti-cancer activity is generally validated by vitro cellular experiments. Therefore, accurate prediction response critical and challenging task for drugs design precision medicine. With development pharmacogenomics, combination efficient feature extraction methods omics data has made it possible use computational models assist...
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants and "anatomical escape" characteristics threaten the effectiveness current coronavirus disease 2019 (COVID-19) vaccines. There is an urgent need to understand immunological mechanism broad-spectrum tract protection guide broader vaccines development. Here we investigate immune responses induced by NS1-deleted influenza virus vectored intranasal COVID-19 vaccine (dNS1-RBD) which provides against SARS-CoV-2...
Abstract Antitumor therapies based on adoptively transferred T cells or oncolytic viruses have made significant progress in recent years, but the limited efficiency of their infiltration into solid tumors makes it difficult to achieve desired antitumor effects when used alone. In this study, an virus (rVSV-LCMVG) that is not prone induce virus-neutralizing antibodies was designed and combined with cells. By transforming immunosuppressive tumor microenvironment immunosensitive one, B16...
Antibody therapeutics for the treatment of COVID-19 have been highly successful. However, recent emergence Omicron variant has posed a challenge, as it evades detection by most existing SARS-CoV-2 neutralizing antibodies (nAbs). Here, we successfully generated panel SARS-CoV-2/SARS-CoV cross-neutralizing sequential immunization two pseudoviruses. Of potential candidates, found that nAbs X01, X10, and X17 offer broad against variants concern, with further identified Class 5 nAb undiminished...
Objective This study examines whether the experience of unmet healthcare needs in a large sample Chinese adults aged 60 and over is associated with adverse health outcomes, how this association varied across related to conditions. Study design The 2013 wave China Health Retirement Longitudinal examined. We adopted latent class analysis identify groups based on Then each identified group, we examined extent which were self-rated depression. To understand channels through adversely affected...
Oncolytic viruses are now well recognized as potential immunotherapeutic agents against cancer. However, the first FDA-approved oncolytic herpes simplex virus 1 (HSV-1), T-VEC, showed limited benefits in some patients clinical trials. Thus, identification of novel that can strengthen therapy is warranted. Here, we identified a live-attenuated swine pseudorabies (PRV-LAV) promising agent with broad-spectrum antitumor activity vitro and vivo.PRV cytotoxicity tumor cells normal was tested using...
Abstract The global incidence rate of kidney cancer (KC) has been steadily increasing over the past 30 years. With aging population, become an escalating concern that necessitates vigilant surveillance. Nowadays, surgical intervention remains optimal therapeutic approach for cancer, while availability efficacious treatments advanced tumors limited. Oncolytic viruses, emerging form immunotherapy, have demonstrated encouraging anti‐neoplastic properties and are progressively garnering public...
Hepatitis B e antigen (HBeAg) is a widely used marker both for chronic hepatitis (CHB) clinical management and HBV-related basic research. However, due to its high amino acid sequence homology core (HBcAg), most of available anti-HBe antibodies are cross-reactive with HBcAg resulting in interference against accurate measurement the status level HBeAg. In study, we generated several monoclonal (mAbs) targeting various epitopes on HBeAg HBcAg. Among these mAbs, novel mAb 16D9, which recognizes...
Sever Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is still a threat to human health globally despite the World Health Organization (WHO) announcing end of COVID-19 pandemic. Continued surveillance SARS-CoV-2 at national borders would be helpful in understanding epidemics novel imported variants and updating local strategies for disease prevention treatment. This study focuses on among travelers entering Xiamen International Airport Port from February August 2023. A total 97...
Ground-level ozone threatens rice production, which provides staple food for more than half of the world's population. Improving adaptability crops to pollution is essential ending global hunger. Rice panicles not only affect grain yield and quality but also plants environmental changes, effects on are well understood. Through an open top chamber experiment, we investigated long-term short-term traits panicles, finding that both significantly reduced number panicle branches spikelets in...
Chronic infection with the hepatitis B virus (HBV) is a leading causes of liver cirrhosis and hepatocellular carcinoma. However, managing HBV treatments challenging due to lack effective monotherapy. Here, we present two combination approaches, both which aim target enhance clearance HBsAg HBV-DNA. The first approach involves use antibodies continuously suppress HBsAg, followed by administration therapeutic vaccine in sequential manner. This results better outcomes compared these...
Seasonal influenza is an acute respiratory infection causing around 500 000 global deaths annually. There unmet medical need to develop more effective antiviral drugs and vaccines against infection. A rapid, accurate, high-throughput titration assay for virus particles or neutralizing antibodies would be extremely useful in these research fields. However, commonly used methods such as tissue culture infective dose plaque-forming units (PFU) particle quantification, the plaque reduction...
Abstract Rising concentration of surface O 3 threatens crop production and food security. To improve the evaluation develop efficient adaptations, it is essential to study effects acute pollution. We adopted this by open‐top chamber (OTC) method found that fumigation elevated (NF40) for short (tillering jointing, heading ripening) long periods during rice growth reduced grain yield 17, 19 25%, respectively, showing both chronic pollution reduce production. Moreover, in comparison with plants...
Sphenothallus is a tubular organism that one of the most widely distributed and longest-ranging genera through Palaeozoic. Despite its apparent cosmopolitan distribution, genus has never been reported from North China. New specimens sp. have discovered in upper part Houjiashan base Mantou formations (early to middle Age 4, Epoch 2, Cambrian) Jiangsu Province, The are small tubes (up 5 mm long) typical characteristics, such as multilayered lamellar structure, subcircular elliptical transverse...
Brachiopods first appeared in the early Cambrian and persist till present. They are one of main lineages marine invertebrates that diversified throughout Palaeozoic reached their maximum diversity high-rank taxonomy during Ordovician. During this time interval, brachiopods were mainly dominated by articulated Orthida Strophomenida, which represent major components Paleozoic Evolutionary Fauna; however, inarticulated lingulid (Order Lingulida) comparatively less abundant received attention...
Small shelly fossils have long been recognized as important evidence of both metazoan evolution and biomineralization during the Cambrian radiation. The marked decline in occurrence, diversity abundance small middle to late Cambrian, when compared with early has often regarded representative a closing phosphatization window. fossil-like assemblages have, however, sparsely reported from entirety Phanerozoic, indicating preservation is possible outside Cambrian. To identify factors enhancing...
We have previously obtained a mouse anti-hepatitis B surface antigen (HBsAg) antibody E6F6 with long-lasting serum HBsAg clearance effects. The epitope-based protein CR-T3-SEQ13 (HBsAg aa 113-135) vaccination therapy in cynomolgus monkeys induced long-term polyclonal antibodies-mediated of the HBV transgenic (HBV-Tg) mice.We isolated monoclonal antibodies from vaccinated monkeys, compared their therapeutic effects E6F6, identified epitopes on HBsAg, determined pharmacokinetics and studied...
Abstract Antibody therapeutics for the treatment of COVID-19 has been highly successful while faces a challenge recent emergence Omicron variant which escapes majority existing SARS-CoV-2 neutralizing antibodies (nAbs). Here, we successfully generated panel SARS-CoV-2/SARS-CoV cross-neutralizing by sequential immunization two pseudoviruses. Of which, nAbs X01, X10 and X17 showed broadly breadths against most variants concern (VOCs) was further identified as Class 5 nAb with undiminished...
Abstract The emergence of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) variants and “anatomical escape” characteristics threaten the effectiveness current coronavirus disease (COVID-19) vaccines. There is an urgent need to understand immunological mechanism broad-spectrum respiratory tract protection guide broader vaccines development. In this study, we investigated immune responses induced by NS1-deleted influenza virus vectored intranasal COVID-19 vaccine (dNS1-RBD) which...