Objective This study explores the clinical characteristics of patients with diabetes severe covid-19, and association survival duration in covid-19. Research design methods In this single-center, retrospective, observational study, laboratory 193 covid-19 were collected. 48 had diabetes, 145 (ie, controls) did not have diabetes. A case was defined as including at least one following criteria: (1) Respiratory rate >30/min. (2) Oxygen saturation ≤93%. (3) PaO 2 /FiO ≤300 mm Hg. (4)...

Abstract Background The triglyceride and glucose index (TyG) has been proposed as a marker of insulin resistance. This study aims to evaluate the association TyG with severity mortality coronavirus disease 2019 (COVID-19). Methods included cohort 151 patients COVID-19 admitted in tertiary teaching hospital Wuhan. Regression models were used investigate between COVID-19. Results In this cohort, 39 (25.8%) had diabetes, 62 (41.1%) severe cases, while 33 (22.0%) died hospital. levels...

Optoelectronic synaptic transistors with hybrid heterostructure channels have been extensively developed to construct artificial visual systems, inspired by the human system. However, optoelectronic taking full advantages of superior behaviors, low-cost processes, low-power consumption, and environmental benignity remained a challenge. Herein, we report fully printed, high-performance transistor based on heterostructures heavy-metal-free InP/ZnSe core/shell quantum dots (QDs) n-type SnO2...

Mechanoreceptors endow humans with the sense of touch by translating external stimuli into coded spikes, inspiring rise artificial mechanoreceptor systems. However, to incorporate slow adaptive receptors-like pressure sensors neurons remains a challenge. Here we demonstrate an rationally integrating polypyrrole-based resistive sensor volatile NbOx memristor, mimic tactile sensation and perception in natural skin, respectively. The enables sensory coding converting mechanical...

Metal halide perovskites are promising for next-generation flexible photodetectors owing to their low-temperature solution processability, mechanical flexibility, and excellent photoelectric properties. However, the defects notorious ion migration in polycrystalline metal often lead high unstable dark current, thus deteriorating detection limit long-term operations. Here, we propose an electrical field modulation strategy significantly reduce current of perovskites-based photodetector more...

Abstract Human visual neurons rely on event-driven, energy-efficient spikes for communication, while silicon image sensors do not. The energy-budget mismatch between biological systems and machine vision technology has inspired the development of artificial use in spiking neural network (SNN). However, lack multiplexed data coding schemes reduces ability SNN to emulate perception systems. Here, we present an neuron that enables rate temporal fusion (RTF) external information. can code...

Background and Aims Sirtuin 2 (SIRT2), an NAD + ‐dependent deacetylase, is involved in various cellular processes regulating metabolic homeostasis inflammatory responses; however, its role hepatic steatosis related disorders unknown. Approach Results Integrating the published genomic data on NAFLD samples from humans rodents available Gene Expression Omnibus, we found that SIRT2 was significantly down‐regulated livers patients with advanced high‐fat diet (HFD)–induced mice. This study...

Abstract Flexible and air‐stable phototransistors are highly demanded for wearable near‐infrared (NIR) image sensors. However, advanced NIR sensors via low‐cost, solution‐based processes remained a challenge. Herein, high‐performance inorganic–organic hybrid achieved based on solution processed n‐type metal oxide/polymer semiconductor heterostructures of In 2 O 3 /poly{5,5′‐bis[3,5‐bis(thienyl)phenyl]‐2,2′‐bithiophene‐3‐ethylesterthiophene]} (PTPBT‐ET). The /PTPBT‐ET phototransistor combines...

Abstract High deep‐ultraviolet (DUV) sensitivity and excellent flexibility of ultrathin gallium oxide (Ga 2 O 3 ) film with an ultrawide bandgap endow its extreme propensity in flexible DUV photodetector especially for space exploration wearable electronics. However, efficient strategy high throughput low cost is highly deficient to realize robust Ga photodetectors face potential harsh environments. In this work, heat‐resistant based on optimized inkjet printing environmental‐friendly...

Abstract Bio‐inspired neuromorphic vision sensors, integrating optical sensing, and processing functions have attracted significant attention for developing future low‐power high‐efficiency imaging systems. However, the compulsory electrical signal modulation to achieve inhibitory behaviors in most reported sensors results additional hardware computational latency. Herein, bidirectional photoresponsive optoelectronic synapses based on In 2 O 3 /Al /Y6 phototransistors are achieved, realizing...

Optoelectronic synaptic devices capable of processing multiwavelength inputs are critical for neuromorphic vision hardware, which remains an important challenge. Here, we develop a bidirectional phototransistor based on two-dimensional ferroelectric semiconductor α-In2Se3, exhibits potentiated and depressed weight update under optical pulse stimulation. Importantly, the optoelectronic behavior can be extended to multiwavelengths (blue, green, red light), could used color recognition. The...

Abstract Memristors based neuromorphic devices can efficiently process complex information and fundamentally overcome the bottleneck of traditional computing on von Neumann architecture. Meanwhile, natural biomaterials have attracted significant attention for biologically integrated electronic due to their excellent biocompatibility, mechanical flexibility, controllable biodegradability. Thus, biomaterial‐based memristors may a transformative impact bridging systems biological systems....

Brain-inspired neuromorphic computing hardware based on artificial synapses offers efficient solutions to perform computational tasks. However, the nonlinearity and asymmetry of synaptic weight updates in reported have impeded achieving high accuracy neural networks. Here, this work develops a memtransistor polarization switching two-dimensional (2D) ferroelectric semiconductor (FES) α-In2 Se3 for computing. The exhibits outstanding characteristics, including near-ideal linearity symmetry...

Narrow-band-gap organic semiconductors have emerged as appealing near-infrared (NIR) sensing materials by virtue of their unique optoelectronic properties. However, limited carrier mobility impedes the implementation large-area, dynamic NIR sensor arrays. In this work, high-performance inorganic-organic hybrid phototransistor arrays are achieved for sensing, taking advantage high electron In2O3 and strong absorption a BTPV-4F:PTB7-Th bulk heterojunction (BHJ) with an enhanced photogating...

Abstract Background Central obesity is associated with an increased risk of hypertension in the general population. However, little known regarding potential relationship between central and among adults a normal body mass index (BMI). Our aim was to assess individuals weight (NWCO) large Chinese Methods We identified 10 719 aged 18 years or older from China Health Nutrition Survey 2015. Hypertension defined by blood pressure measurements, physician diagnosis, use antihypertensive treatment....

In the present work, polyethylenimine-capped CdS quantum dots (PEI-CdS QDs) with bright green fluorescence were synthesized and applied for sensitively selectively detecting nitrite in vegetable water samples. Highly fluorescent environment-friendly PEI-CdS QDs (quantum yield about 8%) diameters of ca. 5 nm easily by using hyperbranched PEI as functional polymer. Formation was verified transmission electron microscopy UV-vis spectroscopy. The intensity as-synthesized enhanced pronouncedly...

A novel anticancer pro-prodrug (GMC-CAE-NO2) with diagnosis and therapy functions based on hypoxia photo sequential control was designed. It provides a platform for constructing theranostic pro-prodrugs to release active drugs controlled by hypoxic status UV illumination.

Blood pressure diseases have increasingly been identified as among the main factors threatening human health. How to accurately and conveniently measure blood is key implementation of effective prevention control measures for diseases. Traditional measurement methods exhibit many inherent disadvantages, example, time needed each difficult determine, continuous causes discomfort, process relatively cumbersome. Wearable devices that enable provide new opportunities hopes. Although machine...

Impaired autophagy has been implicated in the pathogenesis of nonalcoholic fatty liver disease.Catalpol (CAT), a bioactive compound from Rehmannia (Di Huang) glutinosa, is known to ameliorate insulin resistance and histological NAFLD spectrum obese mice.Here, we investigated effects CAT on hepatic steatosis ob/ob high-fat diet-induced mice, as well hepatocytes.In reduced weight, triglyceride cholesterol content, lipogenic enzyme levels increased acid oxidase levels.In addition,...

Metal oxide thin-films transistors (TFTs) produced from solution-based printing techniques can lead to large-area electronics with low cost. However, the performance of current printed devices is inferior those vacuum-based methods due poor film uniformity induced by "coffee-ring" effect. Here, we report a novel approach print high-performance indium tin (ITO)-based TFTs and logic inverters taking advantage such notorious ITO has high electrical conductivity generally used as an electrode...

Organic/inorganic hybrid phototransistors are an emerging class of advanced optoelectronic devices. The separated organic high absorption layer and inorganic carrier transport endow with remarkable sensing performance in a broad spectrum. flexibility, ambient stability, process compatibility metal oxide semiconductors also render them promising for large-area matrix integration wearable applications. Moreover, extraordinary photoelectric behaviors, such as bidirectional photoresponses the...

Abstract It is vital to acquire real‐time pH signals with high resolution as variation can reflect important information regarding health status and physiological environment. Field‐effect transistor (FET)‐based biosensors (bio‐FETs), a kind of potentiometric sensor, are being rapidly developed for detection due their advantages sensitivity, low temperature dependence, portability. More importantly, the scalability bio‐FETs renders them applicable achieving spatial in sensing. In this review...

Short sleep duration has been related to established cardiovascular risk factors, likely obesity, diabetes, hypertension and dyslipidaemia. However, the best of our knowledge, associations between apolipoprotein concentrations their ratios have not investigated date. This study aimed explore independent relationship with (apo) A1, apoB apoB/apoA1 ratio in a Chinese adult population.Data from 7381 participants, aged 18 75 years, National Health Nutrition Survey 2009 were analysed this...

We achieved fully-printed SnO 2 based n-type thin-film transistors with high electrical performance and robust mechanical flexibility, promising for constructing low-cost, high-performance flexible electronic devices circuits.