A5100357793- Mathematical Dynamics and Fractals
- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Cancer-related gene regulation
- Hematopoietic Stem Cell Transplantation
- Platelet Disorders and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Advanced Differential Equations and Dynamical Systems
- Meromorphic and Entire Functions
- Gut microbiota and health
- RNA modifications and cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Geological Studies and Exploration
- Geometric and Algebraic Topology
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
- Blood groups and transfusion
- Gastrointestinal Bleeding Diagnosis and Treatment
- Hemostasis and retained surgical items
- earthquake and tectonic studies
- Protein Degradation and Inhibitors
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
Soochow University
2025
Shanghai Jiao Tong University
2022-2025
Xiamen University
2022-2024
Hunan Normal University
2024
Changsha Normal University
2024
Wenzhou Municipal Sci-Tech Bureau
2023
Southern Medical University
2017-2023
China University of Geosciences
2023
Renji Hospital
2022
Shanghai Sixth People's Hospital
2022
As one of the most common malignant tumors, hepatocellular carcinoma (HCC) is a leading cause cancer-related deaths around world. Emerging studies have indicated that circular RNAs (circRNAs), which play crucial role in HCC pathogenesis and metastasis, are differentially expressed HCC. However, regulatory mechanisms circRNA on sorafenib resistance still unknown. In our study, we identified novel circRNA, circFOXM1, using RNA sequencing (RNA-seq) was increased sorafenib-resistant tissues....
Background The emergence of immunotherapy has revolutionized the paradigm cancer treatment with immune checkpoint blockades (ICB) in solid cancers, including colorectal (CRC). However, only a small subset CRC patients harboring deficient mismatch repair (dMMR) or microsatellite instability-high (MSI-H) benefits from ICB therapy. A very limited response to therapy been achieved MMR-proficient CRC, representing significant challenge limiting clinical application immunotherapy. MMR is critical...
Rationale: Hepatocellular carcinoma (HCC) is one of the most severe cancers worldwide, with few effective targeted therapies for HCC.Lipid metabolic reprogramming emerged as a hallmark cancer metabolism that guides response to antitumoral therapies.Such lipid alteration in critically regulated by mammalian target rapamycin mTOR, which considered promising therapeutic target.Despite efforts, mTOR inhibitors (mTORi) have produced limited clinically, partly due incomplete knowledge mTORC1...
Cancer-associated fibroblasts (CAFs) are significantly involved in determining the patient's prognosis and response to bladder cancer (BLCA) therapy. CAFs can induce epithelial-mesenchymal transformation (EMT) as well complex interaction with immune cells. Hence, it is imperative identify potential markers for enhancing our understanding of BLCA progression regulation. A variety algorithms analyses were employed study, leading development a novel prognostic feature CAFs-Stromal-EMT...
ABSTRACT Osteoblasts provide a microenvironmental niche for B-cell commitment and maturation in the bone marrow (BM). Any abnormity of osteoblasts function may result defect B lymphopoiesis. Signaling from mechanistic target rapamycin complex 1 (mTORC1) has been implicated regulating expansion differentiation osteoblasts. Thus, we raise hypothesis that mTORC1 signaling plays vital role development. Inactivation osterix-expressing cells (mainly osteoblast lineage) through Osx-Cre-directed...
Ras‑associated protein 1A (Rap1A) is a member of the Ras subfamily small GTP‑binding proteins and found to promote metastasis in several types cancer. However, functional role molecular mechanism action Rap1A esophageal squamous cell carcinoma (ESCC) not fully understood. In present study, was be upregulated ESCC tissues its expression correlated with cancer stage. Functional studies revealed that could by stimulating migration invasion vivo vitro. Further study indicated transcriptional...
Objective Circular RNA plasmacytoma variant translocation 1 (circ-PVT1) has been reported to be an oncogene and serves as a prognostic biomarker in several solid cancers hematological malignancies. However, no study performed on the tumorigenesis role of circ-PVT1 acute myeloid leukemia (AML). Thus, this aimed evaluate correlation with disease risk, clinical characteristics, cytogenetics/molecular genetics, prognosis AML.Methods A total 68 de novo AML patients, 30 controls health donors were...
ABSTRACT The role and underlying mechanisms of DNA methylation in osteogenesis/chondrogenesis remain poorly understood. We here reveal methyltransferase 1 (DNMT1), which is responsible for copying onto the newly synthesized strand after replication, overexpressed sponge bone people mice with senile osteoporosis required suppression osteoblast (OB) differentiation mesenchymal stem cells (MSCs) osteoprogenitors. Depletion DNMT1 results demethylation at promoters key osteogenic genes such as...
The serum free light chain (sFlc) levels were measured for 122 Chinese patients with newly diagnosed symptomatic multiple myeloma (NDSMM), and κ/λ ratios (rFlc) calculated. data analyzed the roles of sFlc rFlc in diagnosis prognosis MM. Abnormal and/or detected 99.2% patients, demonstrating that FLC assay is much more sensitive than commonly used methods. Baseline successfully predicted overall survival (OS). median OS was not reached (NR) versus 23 months low sFLC group (sFLC-κ < 180 mg/L...
Hetrombopag as the derivative of ethylidene hydrazine carboxamide was recently developed into a novel patented non-peptide thrombopoietin mimetic and receptor agonist to treat idiopathic thrombocytopenic purpura. To study pharmacokinetics hetrombopag, highly sensitive, rapid reliable liquid chromatography-tandem mass spectrometry (LC–MS/MS) method validated for determination hetrombopag in rat plasma. After protein precipitation extraction, chromatography separation analyte internal standard...
The South-to-North Water Diversion East Project (SNWDP-E) is an effective way to realize the optimal allocation of water resources in China. North Dasha River (NDR) reverse recharge section that receives from Yufu Wohushan Reservoir transfer project line SNWDP. However, dissolved organic matter (DOM) evolution mechanism seasonal projects on tributary waters has not been fully elucidated. In this paper, NDR main object, and changes composition distribution spectral characteristics during...
In this paper we continue the study, began in \cite{CJK2}, of bifurcation locus a family meromorphic functions with two asymptotic values, no critical values and an attracting fixed point. If fix multiplier point, either determines one-dimensional parameter slice for family. We proved that divides into three regions, them analogous to Mandelbrot set one, shift locus, complement set. \cite{FK, CK} it was points corresponding parabolic cycle, or those which some iterate one lands on pole are...
To explore the relationship between cytogenetic and clinical features prognosis for patients with acute monocytic leukemia (M5 type).Chromosome samples were prepared by direct culture of bone marrow 24 hours. Karyotypes 80 M5 analyzed R banding. Rearrangement MLL gene deletion P53 detected fluorescence in situ hybridization (FISH).Forty-three (53.75%) found to have abnormal karyotypes, which included 23 abnormalities chromosome 11 20 other chromosomal abnormalities. Twenty-four had...
To assess the correlation of cytogenetic changes with serum vascular endothelial growth factor (VEGF) and tartrate resistant acid phosphatase (TRacp-5b) levels among elderly patients multiple myeloma (MM).Chromosomal were analyzed a modified culturing method in presence IL-6. Serum VEGF TRacp-5b determined enzyme-linked immunosorbent assays (ELISA).Among 60 MM patients, chromosomal abnormalities found 27 cases, including 22 numerical 15 structural abnormalities. Many had both For 33 normal...
We prove that the canonical Thurston obstruction for a sub-hyperbolic semi-rational branched covering exists if is not CLH-equivalent to rational map.