A5009555282- Influenza Virus Research Studies
- Respiratory viral infections research
- Animal Disease Management and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
- SARS-CoV-2 detection and testing
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- COVID-19 Clinical Research Studies
- Biosensors and Analytical Detection
- Chinese history and philosophy
- Long-Term Effects of COVID-19
- Glutathione Transferases and Polymorphisms
- Microbial infections and disease research
- Aquaculture disease management and microbiota
- Cytomegalovirus and herpesvirus research
- Zoonotic diseases and public health
- Advanced biosensing and bioanalysis techniques
- Medical Research and Treatments
- Renal cell carcinoma treatment
- RNA and protein synthesis mechanisms
- Virology and Viral Diseases
- Herpesvirus Infections and Treatments
- CAR-T cell therapy research
- COVID-19 epidemiological studies
Academy of Military Medical Sciences
2015-2024
Chinese Academy of Agricultural Sciences
2021-2023
Jilin University
2019-2022
University of Bari Aldo Moro
2021
Military Research Institute
2021
Jilin Medical University
2021
The University of Texas at Austin
2021
Hebei Agricultural University
2021
Institute of Special Animal and Plant Sciences
2021
Gansu Agricultural University
2014-2015
New emerging severe acute respiratory syndrome 2 (SARS-CoV-2) has caused a worldwide pandemic. Several animal models of coronavirus disease 2019 (COVID-19) have been developed and applied to antiviral research. In this study, two lethal mouse-adapted SARS-CoV-2 variants (BMA8 C57MA14) with different virulence were generated from hosts, which are characterized by high viral replication titers in the upper lower tract, pulmonary pathology, cytokine storm, cellular tropism, lymphopenia,...
H5N6 avian influenza viruses (AIVs) may pose a potential human risk as suggested by the first documented naturally-acquired virus infection in 2014. Here, we report cases of fatal (AIV) domestic cat and wild birds. These followed infections China preceded an outbreak chickens. The extensive migration routes birds contribute to geographic spread AIVs humans susceptible domesticated animals, from southern northern Additional surveillance is required better understand threat zoonotic transmission AIVs.
Influenza H3N8 viruses have been recovered frequently from wild bird species, including Anseriformes (primarily migratory ducks) and Charadriiformes shorebirds). However, little attention has given to the transmission ability of avian influenza among mammals. Here, we study potential human health threat molecular basis mammalian transmissibility isolated reservoirs. We classified eight into seven different genotypes based on genomic diversity. Six naturally birds acquired bind human-type...
To date, intermediate hosts of SARS-CoV-2 remain obscure and controversial. Several studies have shown that SARS-CoV-2-related pangolin coronavirus (Pangolin-CoV) has a high sequence similarity to might be the initial source SARS-CoV-2; however, biological characteristics Pangolin-CoV are still largely unknown. In this study, we evaluated pathogenicity transmissibility in Syrian golden hamsters Mesocricetus auratus (Linnaeus, 1758) compared it with SARS-CoV-2. could effectively infect...
Abstract H9N2 avian influenza viruses circulate worldwide in poultry and have sporadically infected humans, raising concern whether pandemic potential. Here, we use a guinea pig model to examine serial passage results adaptive viral changes that confer transmissible phenotype wild-type virus. After nine passages of an virus through pigs, productive transmission by direct contact occurred 2/3 pairs. The efficiency increased following the fifteenth 3/3 In contrast, airborne passaged was less...
H9N2 influenza virus has been reported worldwide for several decades, and it evolved into multiple genotypes among domestic poultry. However, the study involving ecology evolution of low pathogenic avian in wild birds China is limited. Here, we carried out surveillance along with East Asian-Australian migratory flyway 2017. To estimate prevalence birds, information on exposure bird populations to viruses using serology, addition virology, would greatly improve monitoring capabilities. In...
Previous studies have shown that B.1.351 and other variants extended the host range of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to mice. Sustained transmission is a prerequisite for viral maintenance in population. However, no evidence natural SARS-CoV-2 wild mice has been documented date. Here, we evaluated replication contact variant rats. The could infect replicate efficiently airways Furthermore, not be transmitted BALB/c or C57BL/6 but with moderate efficiency rats...
Wild aquatic birds are the primary hosts of H13 avian influenza viruses (AIVs). Herein, we performed a genetic analysis two AIVs isolated from wild in China and evaluated their infection potential poultry to further explore for transmission poultry. Our results showed that strains belong different groups, one strain (A/mallard/Dalian/DZ-137/2013; abbreviated as DZ137) belongs Group I, whereas other (A/Eurasian Curlew/Liaoning/ZH-385/2014; ZH385) III. In vitro experiments both DZ137 ZH385 can...
In 2012, an FHV-1-like virus was isolated from a tiger that presented with clinical signs of sialorrhea, sneezing and purulent rhinorrhea. Isolation performed the FK81 cell line, identified by PCR, transmission electron microscopy (TEM), phylogenetic analysis partial thymidine kinase (TK) glycoprotein B (gB) genes. A total 253 bp TK gene 566 gB were amplified trachea PCR/RT-PCR method. Phylogenetic showed isolate belonged to same cluster other FHV-1 strains obtained GenBank. Herpes-like...
The coronavirus disease 2019 pandemic has caused more than 532 million infections and 6.3 deaths to date. reactive neutralizing fully human antibodies of severe acute respiratory syndrome 2 (SARS-CoV-2) are effective detection tools therapeutic measures. During SARS-CoV-2 infection, a large number will be produced. Most isolated from frequently encoded by convergent heavy-chain variable genes. However, viruses can mutate rapidly during replication the resistant variants easily survive evade...
Abstract Background Influenza viruses, especially A virus and B virus, are respiratory pathogens can cause seasonal epidemics pandemics. Severe influenza viruses infection induces strong host-defense response excessive inflammatory response, resulting in acute lung damage, multiple organ failure high mortality. Isoquercitrin is a Chinese medicine monomer, which was reported to have biological activities, including antiviral activity against HSV, IAV, SARS-CoV-2 so on. Aims of this study were...
The duration of SARS-CoV-2 genomic RNA shedding is much longer than that infectious in most COVID-19 patients. It very important to determine the relationship between test results and infectivity for efficient isolation, contact tracing, post-isolation. We characterized viable SARS-CoV-2, viral subgenomic (gRNA sgRNA), rapid antigen positivity nasal washes, oropharyngeal swabs, feces experimentally infected Syrian hamsters. RNA, far those (RAgT) culture positivity. were strongly correlated...
This study aimed to evaluate antimicrobial resistance, virulence, and the genetic diversity of Aeromonas isolated from migratory birds Guangxi Province, Guangdong Ningxia Hui Autonomous Region, Jiangxi Inner Mongolia in China. A total 810 samples were collected, including fresh feces, cloacal swabs, throat swabs. The collected processed subjected bacteriological examination. resistance 21 antibiotics was evaluated. phylogenetic tree constructed using concatenated...
We analyzed size of severe acute respiratory coronavirus 2 (SARS-CoV-2) aerosol particles shed by experimentally infected cynomolgus monkeys. Most exhaled were small, and virus was mainly released early during infection. By postinfection day 6, no detected in breath, but air the isolator contained large quantities aerosolized virus.
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was initially identified in 2019, after it spread rapidly throughout the world. With progression of epidemic, new variants SARS-CoV-2 with faster transmission speeds and higher infectivity have constantly emerged. The proportions people asymptomatically infected or reinfected vaccination increased correspondingly, making prevention control COVID-19 extremely difficult. There...
H5N1 avian influenza viruses are a major pandemic concern. In contrast to the highly virulent phenotype of in humans and many animal models, guinea pigs do not typically display signs severe disease response virus infection. Here, proteomic transcriptional profiling were applied identify host factors that account for observed attenuation A/Tiger/Harbin/01/2002 (H5N1) virulence pigs. RIG-I numerous interferon stimulated genes among proteins with altered expression pig lungs during...
Vaccination is the most effective means to prevent influenza virus infection, although current approaches are associated with suboptimal efficacy. Here, we generated virus-like particles (VLPs) composed of hemagglutinin (HA), neuraminidase (NA) and matrix protein (M1) A/Changchun/01/2009 (H1N1) or without either membrane-anchored cholera toxin B (CTB) ricin (RTB) as molecular adjuvants. The intranasal immunization mice VLPs containing CTB RTB elicited stronger humoral cellular immune...
Avian H3N2 influenza virus follows cross-host transmission and has spread among dogs in Asia since 2005. After 2015-2016, a new subtype canine epidemic occurred North America Asia. The disease prevalence was assessed by virological serological surveillance China. Herein, five (CIV) strains were isolated from 1185 Chinese respiratory samples 2017-2018; these on the evolutionary branch of American CIVs after 2016 genetically far classical strain discovered China before 2016. Serological showed...