Guixue Hu

ORCID: 0000-0003-4666-2221
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About
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Research Areas
  • Animal Virus Infections Studies
  • Virus-based gene therapy research
  • Viral gastroenteritis research and epidemiology
  • Viral Infections and Immunology Research
  • Animal Disease Management and Epidemiology
  • interferon and immune responses
  • Virology and Viral Diseases
  • Herpesvirus Infections and Treatments
  • Viral Infections and Vectors
  • Vector-Borne Animal Diseases
  • Microbial infections and disease research
  • Influenza Virus Research Studies
  • Cancer Research and Treatments
  • Bacteriophages and microbial interactions
  • SARS-CoV-2 and COVID-19 Research
  • Respiratory viral infections research
  • Cytomegalovirus and herpesvirus research
  • Rabies epidemiology and control
  • Toxoplasma gondii Research Studies
  • Hepatitis B Virus Studies
  • Viral Infectious Diseases and Gene Expression in Insects
  • Gut microbiota and health
  • HIV Research and Treatment
  • Parvovirus B19 Infection Studies
  • Transgenic Plants and Applications

Jilin Agricultural University
2016-2025

Jinzhou Medical University
2012-2017

Weatherford College
2017

Harbin Veterinary Research Institute
2010

Chinese Academy of Agricultural Sciences
2010

Shandong Entry-Exit Inspection and Quarantine Bureau
2008

Beihua University
2007

Shanghai Entry-Exit Inspection and Quarantine Bureau
2007

Quanta Computer (China)
2006

Bladder cancer (BCa) is the ninth most common form of in world. There a continuing need not only for improving accuracy diagnostic markers but also development new treatment strategies. Recent studies have shown that renin-angiotensin system (RAS), which include angiotensin type 1 (AT1R), 2(AT2R), and Mas receptors, play an important role tumorigenesis may guide us meeting those needs.In this study, we first observed AT1R expression levels were significantly upregulated BCa specimens while...

10.1186/s13046-017-0542-0 article EN cc-by Journal of Experimental & Clinical Cancer Research 2017-06-09

Abstract H9N2 avian influenza viruses circulate worldwide in poultry and have sporadically infected humans, raising concern whether pandemic potential. Here, we use a guinea pig model to examine serial passage results adaptive viral changes that confer transmissible phenotype wild-type virus. After nine passages of an virus through pigs, productive transmission by direct contact occurred 2/3 pairs. The efficiency increased following the fifteenth 3/3 In contrast, airborne passaged was less...

10.1038/srep15928 article EN cc-by Scientific Reports 2015-11-10

A feline panleukopenia virus (FPV), Giant panda/CD/2018, was isolated from a captive giant panda with mild diarrhea in 2018 Chengdu, China, and further identified via indirect immunofluorescence assay (IFA), transmission electron microscopy (TEM) observation, genetic analysis. Phylogenetic analysis based on the complete VP2 nucleotide sequences showed that it shared high homology Chinese FPV isolates grouped within cluster 1. One unique substitution Gly(G)299Glu(E) capsid protein first...

10.3389/fcimb.2021.820144 article EN cc-by Frontiers in Cellular and Infection Microbiology 2022-02-07

Bocaviruses have been reported to cause respiratory tract infection and gastroenteritis in most animal species. In cats, different genotype bocaviruses identified USA, Japan, Hong Kong Portugal. However, the clear relationship between clinical symptoms FBoV is unknown, prevalence of distribution genotypes China are still unclear.In this study, 197 fecal samples from cats with diarrhea (n = 105) normal 92) were collected regions January 2016 November 2017 investigated using PCR targeting...

10.1186/s12985-018-1034-3 article EN cc-by Virology Journal 2018-08-08

Bluetongue (BT), caused by bluetongue virus (BTV), is an arthropod-borne viral disease in ruminants. However, information about BTV infection yaks China limited. Moreover, no such data concerning Tibetan sheep available. Therefore, 3771 serum samples were collected from 2187 and 1584 between April 2013 March 2014 Plateau, western China, tested for antibodies using a commercially available ELISA kit. The overall seroprevalence of was 17.34% (654/3771), with 20.3% (443/2187) 13.3% (211/1584)...

10.1155/2017/5139703 article EN cc-by BioMed Research International 2017-01-01

Toxoplasma gondii poses a great threat to human health, with no approved vaccine available for the treatment of T. infection. infections are not limited brain, and may also affect other organs especially liver. Identification host liver molecules or pathways involved in replication process lead discovery novel anti-T. targets. Here, we analyzed metabolic profile mice on 11 30 days post infection (dpi) type II Pru strain. Global metabolomics using liquid chromatography-tandem mass...

10.3389/fcimb.2018.00189 article EN cc-by Frontiers in Cellular and Infection Microbiology 2018-06-05

Feline astrovirus (FeAstV) which belonged to the genus Mamastrovirus was first identified in feces of kittens with diarrhea USA 1981 by electron microscopy, and had been reported many countries. Presently, there are no any reports circulation FeAstV mainland China. We performed this study investigate apparent prevalence genetic variability infected cats China for time. tested fecal samples 105 92 asymptomatic five cities northeast RT-PCR targeting RNA-dependent RNA polymerase (RdRp) gene...

10.1371/journal.pone.0205441 article EN cc-by PLoS ONE 2018-10-09

In 2008, an outbreak of canine distemper virus (CDV) infection in monkeys was reported China. We isolated CDV strain (subsequently named Monkey-BJ01-DV) from lung tissue obtained a rhesus monkey that died this outbreak. evaluated the ability on Vero cells expressing SLAM receptors dog, and human origin, analyzed H gene Monkey-BJ01-DV with other strains.The isolate replicated to highest titer dog-origin (10(5.2±0.2) TCID50/ml) monkey-origin (10(5.4±0.1) TCID50/ml), but achieved markedly lower...

10.1186/s12917-016-0757-x article EN cc-by BMC Veterinary Research 2016-08-02

Toxoplasma gondii, a common opportunistic protozoan, is leading cause of illness and mortality among immunosuppressed individuals during congenital infections. Current therapeutic strategies for toxoplasmosis are not fully effective at curtailing disease progression in these cases. Given the parasite ability to influence host immunity metabolism, understanding metabolic alterations host's immune organs T. gondii infection may enhance molecular mechanisms that define pathophysiology...

10.1186/s13071-017-2282-6 article EN cc-by Parasites & Vectors 2017-07-18

Abstract Gyroviruses (GyVs) are small, single-stranded, circular DNA viruses in the genus Gyrovirus , which consists of chicken anemia virus (CAV) prototype and nine other viral species. These different GyV species have been reported chickens, humans, mice, companion animals. To date, CAV has identified feces domestic cats, while circulation cats is currently unknown. In present study, 197 fecal samples were collected from pet northeast China, screened for by PCR. Twelve strains cats....

10.1038/s41598-019-49955-8 article EN cc-by Scientific Reports 2019-09-16

This study aimed to investigate the effects of yeast cultures on antioxidant capacity, rumen fermentation, and growth performance goats in summer. An vitro experiment was conducted using culture supplemented at 0% (control), 0.6% (test 1), 0.9% 2), 1.2% 3) dry matter (DM) weight basal diet. With a 24 h pH value; total short-chain fatty acid, acetic propionic butyric acid concentrations; degradability DM, neutral detergent fiber, fiber were significantly increased (p < 0.05) tests 2 3...

10.3390/fermentation10060307 article EN cc-by Fermentation 2024-06-08

Enterocytozoon bieneusi, the most common zoonotic pathogen of microsporidiosis, has been found in various animals and humans, but no information is available concerning prevalence genotypes E. bieneusi white yaks (Bos grunniens). In present study, 353 faecal samples from Tianzhu Tibetan Autonomous County, Gansu Province, Northwestern China, were collected examined by PCR amplification internal transcribed spacer gene to estimate identify their genotypes. Of samples, 4 (1.13%) tested...

10.1155/2017/5790181 article EN BioMed Research International 2017-01-01

Enzootic bovine leukosis (EBL) is a chronic lymphosarcoma disease of cattle caused by leukemia virus (BLV). No information available concerning the epidemiology BLV infection in yaks ( Bos mutus ). One thousand five hundred and eighty-four serum samples from 610 black 974 white Gansu province, northwest China, were collected between April 2013 March 2014 tested for antibodies using commercially ELISA kit. The overall seroprevalence was 21.09% (334/1584), with 24.26% (148/610) 19.10%...

10.1155/2016/9170167 article EN BioMed Research International 2016-01-01
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