A5007185929- Cytokine Signaling Pathways and Interactions
- Fungal Biology and Applications
- Cancer Cells and Metastasis
- Cancer, Stress, Anesthesia, and Immune Response
- Synthesis and biological activity
- Molecular Biology Techniques and Applications
- Heat shock proteins research
- HER2/EGFR in Cancer Research
- Connexins and lens biology
- Cancer-related gene regulation
- Hippo pathway signaling and YAP/TAZ
- Oral microbiology and periodontitis research
- Neuropeptides and Animal Physiology
- Cancer Mechanisms and Therapy
- Gene expression and cancer classification
- Autophagy in Disease and Therapy
- CRISPR and Genetic Engineering
- Polysaccharides and Plant Cell Walls
- Dental Health and Care Utilization
- Ovarian cancer diagnosis and treatment
- Peptidase Inhibition and Analysis
- Food Quality and Safety Studies
- PI3K/AKT/mTOR signaling in cancer
- Respiratory viral infections research
- Immune Response and Inflammation
Baoshan College
2025
Henan University
2012-2024
Air Force Medical University
2024
East China Normal University
2024
Shanxi Medical University
2024
Shanxi Province Hospital of Traditional Chinese Medicine
2024
Stomatological Hospital of Chongqing Medical University
2020-2023
Nanjing Agricultural University
2020-2023
Ministry of Agriculture
2020-2023
Chongqing Medical University
2020-2023
// Zhengyan Yang 1,* , Liang Guo Dan Liu 1 Limin Sun Hongyu Chen Que Deng Yanjun 2 Ming Yu Yuanfang Ma Ning and Shi Institute of Basic Medical Sciences, Beijing, P.R. China Laboratory Cellular Molecular Immunology, School Henan University, Kaifeng, * These authors contributed equally to this work Correspondence: Shi, email: Guo, Keywords : trastuzumab, gastric cancer, STAT3, Notch Received September 29, 2014 Accepted December 27, Published 31, Abstract In the present study, we demonstrate...
Abstract Glucocorticoids are stress‐responsive neuroendocrine mediators and play an important role in malignant progression, especially solid tumours. We demonstrate a novel mechanism by which glucocorticoids modulate p53‐dependent miR‐145 expression HPV‐positive cervical cancer cells through induction of E6 proteins. found that was reduced tissues. Cortisol induced HPV‐E6 suppressed p53 cells. MiR‐145 wild‐type ‐dependent, cortisol‐induced down‐regulation prevented chemotherapy‐induced...
Abstract Trastuzumab is currently used for patients with Her2+ advanced gastric cancer. However, the response rate to trastuzumab among low. The molecular mechanisms underlying resistance in cancer are unknown. Our vitro data show that activation of β2-adrenergic receptor (β2-AR) triggered by catecholamine caused “targeting failure” cells. antitumor activities were significantly impeded chronic stimulation cells and mice bearing human xenografts. Mechanistically, induced upregulation MUC4...
Myocardial infarction (MI) is a leading cause of death worldwide for which there no cure. Although cardiac cell well-recognized pathological mechanism MI, therapeutic blockade to treat MI not straightforward. Death receptor 5 (DR5) and its ligand TRAIL [tumor necrosis factor (TNF)-related apoptosis-inducing ligand] are up-regulated in but their roles remodeling unknown. Here, we report that blocking with soluble DR5 immunoglobulin fusion protein diminished by preventing inflammation rats,...
Abstract Lung cancer, especially lung adenocarcinoma, is one of the most common neoplasms worldwide. However, mechanisms underlying its initiation, development, and metastasis are still poorly understood. Destrin (DSTN) a member ADF/cofilin family. Its detailed biological function remains unknown, although it reported that DSTN involved in cytoskeleton remodeling regulation actin filament turnover. Recent evidence has shown high expression cofilin-1 associated with invasion poor prognosis...
Two lactic acid bacteria (LAB) strains of Lactobacillus plantarum 21802 and brevis 6239 were selected combined for fermentation grape juice. The changes sugars, organic acids, volatiles, phenolic compounds as well antioxidant capacity the juice characterized. Results showed that with LAB led to a slight decrease in sugar content increased content. sugars mainly consumed at initial stage fermentation, while malic was completely during fermentation. contents total phenolics flavonoids...
Abstract As a master regulator of the balance between NO signaling and protein S-nitrosylation, S-nitrosoglutathione (GSNO) reductase (GSNOR) is involved in various developmental processes stress responses. However, proteins specific sites that can be S-nitrosylated, especially microorganisms, physiological functions S-nitrosylated remain unclear. Herein, we show ganoderic acid (GA) content GSNOR-silenced (GSNORi) strains significantly lower (by 25%) than wild type (WT) under heat (HS)....
Caries in young children has received more and attention. The study of the oral microbiota may help to understand polymicrobial etiology dental caries.To investigate diversity structure microbial communities saliva samples from 5-year-old with versus without caries.A total 36 were collected 18 high caries (HB group) (NB group). Then, 16S rDNA was amplified bacterial using polymerase chain reaction, high-throughput sequencing performed Illumina Novaseq platforms.Sequences clustered into...
Epithelial cell polarization and integration are essential to their function loss of epithelial polarity tissue architecture correlates with the development aggressive tumors. Erbin is a basolateral membrane-associated protein. The roles in establishing regulating adhesion have been suggested. also negative regulator Ras-Raf-ERK (extracellular signal-regulated kinase) signaling pathway. However, potential functions human cancer basically unknown. In present study, we show, for first time,...
Nitric oxide (NO) is an important signalling molecule in stress response of organisms. We previously reported that NO decreases heat (HS)-induced ganoderic acid (GA) accumulation Ganoderma lucidum. To explore the mechanisms by which modulates GA biosynthesis under HS, effect on reactive oxygen species (ROS) content was examined. The results showed decreased production mitochondrial ROS (mitROS) 60% HS. Further research revealed reduced mitROS inhibiting aconitase (Acon) activity....
Our previous studies show that β2-adrenergic receptor (β2-AR) is highly expressed in most Her2-overexpressing breast cancers. However, the mechanisms underlying upregulation of β2-AR expression cancer cells are not fully understood. The clinical significance overexpression unclear. Human MCF-7 and MCF-7/Her2 were transfected with let-7 mimics or inhibitors. was analyzed by Western blot. status primary metastatic sites human tissue microarrays containing 49 tumors 50 lymph node tissues...
Phosphoglucose isomerase (PGI) is a key enzyme that participates in polysaccharide synthesis, which responsible for the interconversion of glucose-6-phosphate (G-6-P) and fructose-6-phosphate (F-6-P), but there little research focusing on its role fungi, especially higher basidiomycetes. The pgi gene was cloned from Lentinula edodes named lepgi. Then, lepgi-silenced strains were constructed by RNA interference. In this study, we found had significantly less biomass than wild-type (WT)...
While the effect of fluoride on severe early childhood caries (S-ECC) is clear, knowledge how it influences oral microbiota and consequential effects health limited. In this cohort study, we investigated changes introduced in ecosystem before after using varnish 54- to 66-month-old individuals (n=90: 18 children were sampled at 5 different time points). 16S rDNA was amplified from bacterial samples polymerase chain reaction, high-throughput sequencing performed Illumina MiSeq platforms. Many...