A5103005702- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- Retinoids in leukemia and cellular processes
- Cell Adhesion Molecules Research
- interferon and immune responses
- HER2/EGFR in Cancer Research
- Immunotherapy and Immune Responses
- Air Quality and Health Impacts
- Advanced Proteomics Techniques and Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Chemokine receptors and signaling
- Immune Response and Inflammation
- Autophagy in Disease and Therapy
- Cancer, Stress, Anesthesia, and Immune Response
- Neuropeptides and Animal Physiology
- Hippo pathway signaling and YAP/TAZ
- Liver Diseases and Immunity
- Arsenic contamination and mitigation
- Advanced biosensing and bioanalysis techniques
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
Academy of Military Medical Sciences
2006-2021
Chinese Institute for Brain Research
2018-2019
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2008-2017
Beijing Institute of Education
2015-2017
Peking University
2015
China Pharmaceutical University
2011
National Center of Biomedical Analysis
2003-2008
Henan University
2008
West China Medical Center of Sichuan University
2008
Institute of Physiology and Basic Medicine
2006-2007
Chemotherapeutic resistance in breast cancer, whether acquired or intrinsic, remains a major clinical obstacle. Thus, increasing tumor cell sensitivity to chemotherapeutic agents will be helpful improving the management of cancer. In present study, we found an induction HO-1 expression doxorubicin (DOX)-treated MDA-MB-231 human adenocarcinoma cells, which showed insensitivity DOX treatment. Knockdown dramatically upregulated incidence death under treatment, indicating that functions as...
ABSTARCT Epidemiological and clinical studies have increasingly shown that fine particulate matter (PM2.5) is associated with a number of pathological respiratory diseases, such as bronchitis, asthma, chronic obstructive pulmonary disease, which share the common feature airway inflammation induced by particle exposure. Thus, understanding how PM2.5 triggers inflammatory responses in system crucial for study toxicity. In current study, we found exposing human bronchial epithelial cells...
Abstract Background Stress, anxiety and depression can cause complex physiological neuroendocrine changes, resulting in increased level of stress related hormone catecholamine, which may constitute a primary mechanism by factors impact gene expression tumors. In the present study, we investigated effects catecholamine stimulation on MMP-7 gastric cancer cells elucidated molecular mechanisms up-regulation through an adrenergic signaling pathway. Results Increased was identified at both mRNA...
Abstract Glucocorticoids are stress‐responsive neuroendocrine mediators and play an important role in malignant progression, especially solid tumours. We demonstrate a novel mechanism by which glucocorticoids modulate p53‐dependent miR‐145 expression HPV‐positive cervical cancer cells through induction of E6 proteins. found that was reduced tissues. Cortisol induced HPV‐E6 suppressed p53 cells. MiR‐145 wild‐type ‐dependent, cortisol‐induced down‐regulation prevented chemotherapy‐induced...
Abstract Trastuzumab is currently used for patients with Her2+ advanced gastric cancer. However, the response rate to trastuzumab among low. The molecular mechanisms underlying resistance in cancer are unknown. Our vitro data show that activation of β2-adrenergic receptor (β2-AR) triggered by catecholamine caused “targeting failure” cells. antitumor activities were significantly impeded chronic stimulation cells and mice bearing human xenografts. Mechanistically, induced upregulation MUC4...
Abstract Background c-Jun/AP-1 has been linked to invasive properties of aggressive breast cancer. Recently, it reported that overexpression c-Jun in cancer cell line MCF-7 resulted increased AP-1 activity, motility and invasiveness the cells vitro tumor formation nude mice. However, role metastasis human vivo is currently unknown. Methods To further investigate direct involvement tumorigenesis metastasis, present study, effects were studied both Results Ectopic promoted growth a significant...
The presentation of peptides to T cells by MHC class II molecules is critical importance in specific recognition a pathogen the immune system. level directly influences lymphocyte activation. aim this study was identify possible mechanisms down-regulation expression Zta during EBV lytic cycle. data present demonstrated that ectopic can strongly inhibit constitutive and CIITA Raji cells. negative effect on promoter activity also observed. Scrutiny DNA sequence III revealed presence two...
Short- and long-term exposure to particulate matter (PM) 2.5 instigates adverse health effect upon the cardiovascular (CV) system. Disclosing molecular events by which PM2.5 evokes CV injuries is essential in developing effective risk-reduction strategy. Here we found that rats after intratracheally instillation with displayed increased circulating level of ANGII, major bioactive peptide renin-angiotensin-system (RAS), resulted from elevation ANGII production vascular endothelium. Further...
Abstract Purpose: French-American-British (FAB) classification of acute leukemia with genetic heterogeneity is important for treatment and prognosis. However, the distinct protein profiles that contribute to subtypes facilitate molecular definition are still unclear. Experimental Design: The proteins leukemic cells from 61 cases characterized by FAB were separated two-dimensional electrophoresis, differentially expressed spots identified both matrix-assisted laser...
Exposure to ultraviolet B (UVB) irradiation from sunlight induces the upregulation of VEGF, a potent angiogenic factor that is critical for mediating angiogenesis-associated photodamage. However, molecular mechanisms related UVB-induced VEGF expression have not been fully defined. Here, we demonstrate one catalytic subunits IκB kinase complex (IKK), IKKα, plays role in mouse embryonic fibroblasts (MEFs), which requires IKKα activity but independent IKKβ, IKKγ and transactivation NF-κB. We...
Abstract One of the health hazards PM2.5 exposure is to induce pulmonary inflammatory responses. In our previous study, we demonstrated that exposing both immortalized and primary human bronchial epithelial cells results in a significant upregulation VEGF production, typical signaling event trigger chronic airway inflammation. Further investigations showed strongly induces ATR/CHK1/p53 cascade activation, leading induction DRAM1-dependent autophagy mediate expression by activating Src/STAT3...
Chronic arsenic exposure is associated with the development of several cardiovascular (CV) diseases, including hypertension, carotid atherosclerosis and microvascular abnormalities. Upregulation systemic aortic angiotensin II (ANGII) signaling has been proposed to contribute arsenic-induced vascular dysfunction. However, underlying mechanisms ANGII augmentation attendant pathological effects on CV system induced by remain largely unknown. Here, we reported that human umbilical vein...
Changes in the expression of glycosyltransferases directly influence oligosaccharide structures and conformations cell surface glycoproteins consequently cellular phenotype transitions biological behaviors. In present study, we show that all-trans-retinoic acid (ATRA) modulates N-glycan composition intercellular adhesion molecule-1 (ICAM-1) by manipulating two N-acetylglucosaminyltransferases, GnT-III GnT-V, via ERK signaling pathway. Exposure various cells to ATRA caused a remarkable gel...