A5025646378- Cancer-related molecular mechanisms research
- Tuberculosis Research and Epidemiology
- Cellular Mechanics and Interactions
- Radiomics and Machine Learning in Medical Imaging
- Fetal and Pediatric Neurological Disorders
- Mycobacterium research and diagnosis
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Ophthalmology and Visual Impairment Studies
- Circular RNAs in diseases
- Urologic and reproductive health conditions
- RNA Research and Splicing
- Renal cell carcinoma treatment
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Autophagy in Disease and Therapy
- Sarcoma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Bone and Dental Protein Studies
- Ferroptosis and cancer prognosis
- Cerebrospinal fluid and hydrocephalus
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Spinal Dysraphism and Malformations
China Medical University
2014-2025
Huazhong University of Science and Technology
2015-2025
Changchun Normal University
2025
Union Hospital
2025
Hangzhou Normal University
2024
Anyang Hospital of Traditional Chinese Medicine
2023
First Affiliated Hospital of Zhengzhou University
2021
Beijing YouAn Hospital
2021
University of California, Los Angeles
2019-2021
The First Affiliated Hospital, Sun Yat-sen University
2020
Reliable and accurate predictive models are necessary to drive the success of radiomics. Our aim was identify optimal radiomics-based machine learning method for isocitrate dehydrogenase (IDH) genotype prediction in diffuse gliomas.Eight classical methods were evaluated terms their stability performance pre-operative IDH prediction. A total 126 patients enrolled analysis. Overall, 704 radiomic features extracted from MRI images analyzed. The randomly assigned either training set or...
Abstract Previously, we have identified ZFAS1 as a potential new long non-coding RNA (lncRNA) biomarker of acute myocardial infarction (MI) and sarcoplasmic reticulum Ca 2+ -ATPase 2a (SERCA2a) inhibitor, causing intracellular overload contractile dysfunction in mouse model MI. In the current study, aimed to evaluate effects on apoptosis cardiomyocytes MI model. Knockdown endogenous by virus-mediated silencing shRNA or si partially abrogated ischemia-induced cardiomyocytes. Overexpression...
Glioma stem-like cells (GSCs) are regarded as the sources of oncogenesis, recurrence, invasion and chemoresistance in malignant gliomas. Growing evidence suggests that microenvironment surrounding GSCs interacts with tumor to influence biological behavior; however, functional mechanisms involved still unclear. In present study, we investigated modulation triggered by fibronectin (FN), a main component extracellular matrix (ECM), terms cell adhesion, differentiation, proliferation...
Myocardial infarction (MI) is a leading cause of death worldwide for which there no cure. Although cardiac cell well-recognized pathological mechanism MI, therapeutic blockade to treat MI not straightforward. Death receptor 5 (DR5) and its ligand TRAIL [tumor necrosis factor (TNF)-related apoptosis-inducing ligand] are up-regulated in but their roles remodeling unknown. Here, we report that blocking with soluble DR5 immunoglobulin fusion protein diminished by preventing inflammation rats,...
Chemotherapy resistance to glioblastoma (GBM) remains an obstacle that is difficult overcome, leading poor prognosis of GBM patients. Many previous studies have focused on mechanisms intrinsic cancer cells; the microenvironment surrounding tumor cells has been found more recently significant impacts response chemotherapeutic agents. Extracellular matrix (ECM) proteins may confer cell adhesion-mediated drug (CAMDR). Here, expression ECM laminin, vitronectin, and fibronectin was assessed in...
Long intergenic non-coding RNAs (lincRNAs) are associated with the progression of glioblastoma (GBM). However, how linc01094 contributes to growth and metastatic phenotypes GBM remains not fully studied.The expression levels miR-126-5p in tissues cell lines were analyzed using qRT-PCR. Loss-of-function experiments performed detect biological activity GBM. Glioblastoma tumor model was constructed explore impact on vivo. Linc01094-sponged certified by luciferase reporter assay RNA...
This study aimed to investigate the feasibility, acceptability, and preliminary efficacy of a ventriculosagittal sinus (VSS) shunt in treatment hydrocephalus with elevated cerebrospinal fluid (CSF) protein content. In this single-center retrospective analysis, we enrolled 80 patients CSF levels. Based on these procedures, primary cohort was divided into two groups using (CSFP) for subsequent analysis determine relationship between clinical effect CSFP. Preoperative postoperative computer...
To explore the value of pre-treatment MRI radiomic features in individualized prediction therapeutic response carbon ion radiotherapy (CIRT) for prostate cancer patients.Twenty-three patients with localized treated by CIRT were enrolled analysis. Prostate tumors manually delineated on T2-weighted (T2w) images and apparent diffusion coefficient (ADC) maps acquired before CIRT. Abundant extracted from delineations, which randomly deformed to account delineation uncertainty. The robust selected...
The problems of tuberculosis (TB) and its drug resistances are very severe in China. New therapeutic agents or regimens to treat multi-drug-resistant (MDR-TB) urgently needed. We studied the effects Ag85A DNA vaccine alone combination with rifampin (RFP) pyrazinamide (PZA) for treatment MDR-TB mice. significantly increased production IFN-γ, but lowered IL-4. Seventy female BALB/c mice infected Mycobacterium clinical isolate HB361, which was resistant RFP isoniazid sensitive PZA, were treated...
The situation of tuberculosis (TB) is very severe in China. New therapeutic agents or regimens to treat TB are urgently needed. In this study, Mycobacterium tuberculosis-infected mice were given immunotherapy intramuscularly with Ag85A/B chimeric DNA saline, plasmid vector pVAX1, vaccae vaccine. treated showed significantly higher numbers T cells secreting interferon-gamma (IFN-γ), more IFN-γ splenocyte culture supernatant, Th1 and Tc1 cells, ratios Th1/Th2 Tc1/Tc2 whole blood, indicating a...
To investigate the efficiency of diffusion tensor imaging (DTI) fiber-tracking based neuronavigation and assess its usefulness in preoperative surgical planning, prognostic prediction, intraoperative course outcome improvement.Seventeen patients with cerebral masses adjacent to corticospinal tract (CST) were given standard magnetic resonance DTI examination. By incorporation data, relation between tumor white matter tracts was reconstructed assessed system. Distance from border CST...
Despite the fact that temozolomide (TMZ) has been widely accepted as key chemotherapeutic agent to prolong survival of patients with glioblastoma, failure and recurrence cases can still be observed in clinics. Glioma stem-like cells (GSCs) are thought responsible for drug resistance. In this study, we investigate whether endothelial monocyte-activating polypeptide-II (EMAP-II), a pro-inflammatory cytokine, enhance TMZ cytotoxicity on U87MG GSCs or not. As described prior research, have...
The only licensed vaccine Mycobacterium bovis Bacillus Calmette-Guérin (BCG) cannot prevent the prevalence of tuberculosis (TB), which remains a major public health problem worldwide. A more effective TB than BCG is urgently needed. Subunit promising strategy, and suitable adjuvants will benefit development subunit vaccines. MTO, consisting monophosphoryl lipid (MPLA), trehalose-6,6'-dibehenate (TDB), MF59, was developed as an adjuvant because its ability to evoke Th1-type T cell responses,...
Collateral flow is associated with clinical outcomes for patients Moyamoya disease and served as a parameter patient selection of therapeutic strategies. Therefore, we explored whether noninvasive imaging modality, computed tomography perfusion (CTP) source images (CTP-Sis), could be used to identify the presence intensity collateral using digital subtraction angiography (DSA) gold standard flow.CTP-Sis DSA were performed 24 unilateral disease. A grading system was developed based on...