A5101556716- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Assisted Reproductive Technology and Twin Pregnancy
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Neuroinflammation and Neurodegeneration Mechanisms
- Viral-associated cancers and disorders
- Metabolomics and Mass Spectrometry Studies
- Monoclonal and Polyclonal Antibodies Research
- Genomics and Phylogenetic Studies
- Preterm Birth and Chorioamnionitis
- Healthcare and Venom Research
- Circular RNAs in diseases
- Ectopic Pregnancy Diagnosis and Management
- Bacteriophages and microbial interactions
- Porphyrin and Phthalocyanine Chemistry
- Selenium in Biological Systems
- Hippo pathway signaling and YAP/TAZ
- Neuroscience and Neuropharmacology Research
- Reproductive Biology and Fertility
- Cancer-related Molecular Pathways
Fujian Medical University
2016-2025
Fujian Provincial Hospital
2019-2025
Nanfang Hospital
2019-2024
Hebei Medical University
2014-2024
Southern Medical University
2017-2024
Jimei University
2023-2024
Xiamen University
2019-2024
Shanghai Jiao Tong University
2022-2024
Ministry of Education of the People's Republic of China
2024
Southern University of Science and Technology
2019-2023
Abstract Given the challenge of multidrug resistance in antibiotics, non‐antibiotic–dependent antibacterial strategies show promise for anti‐infective therapy. V 2 C MXene‐based nanomaterials have demonstrated strong biocompatibility and photothermal conversion efficiency (PCE) therapy (PTT). However, limitation MXene's laser irradiation to near‐infrared region I (NIR‐I) restricts tissue penetration, making it difficult achieve complete bacterial eradication with single‐effect therapeutic...
Abstract Background Radiotherapy is a critical treatment modality for nasopharyngeal carcinoma (NPC). However, the mechanisms underlying radiation resistance and tumour recurrence in NPC remain incompletely understood. Methods Oxidised lipids were assessed through targeted metabolomics. Ferroptosis levels evaluated using cell viability, clonogenic survival, lipid peroxidation, transmission electron microscopy. We investigated biological functions of glutathione S -transferase mu 3 (GSTM3)...
Selenium is known for its antioxidant properties, making selenoproteins candidate molecules mitigation of neurological disorders in which oxidative stress has been implicated. The selenium transport protein, selenoprotein P, essential neuronal survival and function. We sought to determine whether P expression associated with Alzheimer's disease pathology. examined postmortem tissue from individuals the hallmark lesions without these lesions. Selenoprotein immunoreactivity was co-localized...
Fortunately, the majority of children conceived through assisted reproductive technologies (ARTs) appear healthy; however, metabolic abnormalities, including elevated glucose and increased altered adipose tissue deposition, have been reported in adolescents. To parse out factors that may be responsible, we investigated effects two different ARTs--in vitro fertilization (IVF) intracytoplasmic sperm injection (ICSI)--as well as somatic cell nuclear transfer (SCNT) on clearance, body weight,...
Aberrant cancer metabolism contributes to cell proliferation and tumor progression. However, the contribution of enhanced glycolysis, observed during metabolism, pathogenesis progression nasopharyngeal carcinoma (NPC) remains unclear. CYLD, an NF-κB inhibitor, is frequently deficient in NPC. Here, we investigated role CYLD metabolic reprogramming NPC found that restoration expression suppressed glycolysis cells. Mechanistic dissection showed stabilized p53 facilitated its nuclear...
Diabetes exacerbates neuronal cell death induced by cerebral ischemia. One contributing factor is enhanced acidosis during Astrocytes are vulnerable to hypoxia under acidic conditions in vitro and may be targets of ischemia diabetic conditions. The objective this study was determine whether diabetes would cause damage astrocytes after an ischemic brain injury vivo. Diabetic nondiabetic rats were subjected 5 min forebrain followed 30 min, 6 h, or 1 3 days recovery. results showed that caused...
Up-regulation of angiotensin-converting enzyme in the aortic wall causes aneurysms fibulin-4–deficient mice, which can be prevented by losartan or captopril.
Programmed cell death ligand 1 (PD-L1) is an important immune-inhibitory protein expressed on cancer cells to mediate escape through interaction with PD-1 activated T lymphocytes (T cells). Previously, we reported that colon and breast stem (CSCs) much higher levels of PD-L1 than their parental cells, suggesting they will be more resistant immune attack.We investigated the underlining mechanism increase in CSCs, a special focus effect insulin epithelial growth factor (EGF), two fundamental...
Nasopharyngeal carcinoma (NPC) poses a significant health burden in specific regions of Asia, and some NPC patients have bone metastases at the time initial diagnosis. Bone metastasis can cause pathologic fractures pain, reducing patients' quality life, is associated with worse survival. This study aims to unravel complex role insulin-like growth factor 1 receptor (IGF-1R) metastasis, offering insights into potential therapeutic targets. We assessed IGF-1R expression cells explored its...
In both male and female germ cells of mice, retinoic acid (RA) is a meiosis-inducing factor. the present study, we used cell culture system to examine direct effects RA on meiotic initiation in at stage when they normally enter mitotic arrest determine extent which fetal can respond exogenous alter their sex-specific pathway. Male between 13.5 15.5 days postcoitum (dpc) were isolated from Pou5fl-green fluorescent protein transgenic fetuses cultured with or without for up 6 days. absence RA,...
Cancer stem-like cells, possessing "stemness" properties, play crucial roles in progression, metastasis, and drug resistance various cancers. Viral microRNAs (such as EBV-miR-BART7-3p), exogenous regulators, have been discovered to regulate malignant progression of nasopharyngeal carcinoma (NPC), suggesting a possible role viral imposing stemness. In this study, we found that EBV-miR-BART7-3p induce stemness NPC cells. We firstly reported increased the percentage side population development...
Abstract miRNAs are expected to become potential biomarkers in the diagnosis and prognosis of Esophageal cancer (EC). Through a series screening, miR-34a-5p, miR-148a-3p miR-181a-5p were selected as EC-associated miRNAs. Based on AllGlo probe, novel absolute quantitative RT-qPCR method with high sensitivity, specificity accuracy was established for detecting Then clinical significance these 3 explored 213 patients (166 cases EC 47 benign diseases) 170 normal controls. Compared controls,...
Resistance to radiotherapy is one of the main causes treatment failure in patients with nasopharyngeal carcinoma (NPC). Epstein-Barr virus (EBV) infection an important factor pathogenesis NPC, and EBV-encoded microRNAs (miRNAs) promote NPC progression. However, role miRNAs radiosensitivity remains unclear. Here, we investigated effects EBV-miR-BART8-3p on resistance cells vitro vivo, explored underlying molecular mechanisms. Inhibitors ataxia telangiectasia mutated (ATM)/ataxia Rad3-related...
Abstract Radiotherapy is essential to the treatment of nasopharyngeal carcinoma (NPC) and acquired or innate resistance this therapeutic modality a major clinical problem. However, underlying molecular mechanisms in radiation NPC are not fully understood. Here, we reanalyzed microarray data from public databases identified protein tyrosine phosphatase receptor type D ( PTPRD ) as candidate gene. We found that was downregulated tissues cell lines with its promoter hypermethylated. Functional...
Background Ovarian cancer is a lethal female with rising incidence that often diagnosed late due to lack of symptoms, affecting survival and quality life. Studies suggest dietary factors, especially the levels branched-chain amino acids such as valine, may influence its development. While valine essential for metabolism, specific role in ovarian remains unclear, necessitating further research.
Identification of pathogen-inducible promoters largely lags behind cloning the genes for disease resistance. Here, we cloned soybean GmaPPO12 gene and found that it was rapidly strongly induced by Phytophthorasojae infection. Computational analysis revealed its promoter contained many known cis-elements, including several defense related transcriptional factor-binding boxes. We showed could mediate induction GUS expression upon infection in both transient assays Nicotianabenthamiana stable...
Ivermectin (IVM) could cause potential neurotoxicity; however, the precise molecular mechanisms remain unclear. This study explores cytotoxicity of IVM in human neuroblastoma (SH-SY5Y) cells and underlying mechanisms. The results show that treatment (2.5–15 μM) for 24 h induce dose-dependent cell death SH-SY5Y cells. Compared to control, significantly promoted production ROS, mitochondrial dysfunction, apoptosis. also mitophagy autophagy, which were charactered by decreased expression...
Smooth muscle cell marker, SM22α, was down-regulated in the pathogenesis of arterial diseases including atherosclerosis, restenosis and abdominal aortic aneurysms. However, question still exists whether this down-regulation actively contributes to vascular diseases. In an ongoing effort understand role here we explored transcriptome profiling by RNA-Seq from arteries SM22α(-/-) SM22α(+/+) mice. Analysis revealed that most enriched pathways caused SM22α-knockout were hematopoiesis,...
Abstract DCBLD2 is a neuropilin‐like transmembrane protein that up‐regulated during arterial remodeling in humans, rats, and mice. Activation of PDGFR‐β via PDGF triggers receptor phosphorylation endocytosis. Subsequent activation downstream signals leads to the stimulation phenotypic conversion VSMCs wall proliferation, which are common pathological changes vascular diseases such as atherosclerosis, hypertension, restenosis after angioplasty. In this study, we hypothesized regulates...
Retinoic acid (RA) is a meiosis-inducing factor. Primordial germ cells (PGCs) in the developing ovary are exposed to RA, resulting entry into meiosis. In contrast, PGCs testis enter mitotic arrest differentiate prospermatogonia. Sertoli express CYP26B1, an RA-metabolizing enzyme, providing simple explanation for why XY do not initiate meios/is. However, regulation of likely more complex. To investigate mechanisms that regulate male cell differentiation, we cultured XX and at 11.5 12.5 days...
Targeted delivery of therapeutic drugs using nanoparticles to the highly aggressive triple negative breast cancer cells has potential reduce side effects and drug resistance. Cell entry into can be enhanced by incorporating cell binding receptor molecules on surface enhance receptor-mediated pathways, including clatherin or caveolae endocytosis. However, for cells, these pathways may not effective, with more rapid high volume uptake from macropinocytosis phagocytosis being significantly...