Abstract miRNAs are expected to become potential biomarkers in the diagnosis and prognosis of Esophageal cancer (EC). Through a series screening, miR-34a-5p, miR-148a-3p miR-181a-5p were selected as EC-associated miRNAs. Based on AllGlo probe, novel absolute quantitative RT-qPCR method with high sensitivity, specificity accuracy was established for detecting Then clinical significance these 3 explored 213 patients (166 cases EC 47 benign diseases) 170 normal controls. Compared controls,...

Abstract Diabetic cystopathy (DCP) is a prevalent etiology of bladder dysfunction in individuals with longstanding diabetes, frequently leading to interstitial fibrosis. Research investigating the initial pathological alterations DCP notably scarce. To comprehend development fibrosis and find effective biomarkers for its diagnosis, we prepared streptozotocin-induced long-term diabetic SD rats exhibiting type 1 diabetes phenotype histology detection. After observing myofibroblast...

Abstract CYP2C19 gene has multiple single nucleotide polymorphism (SNP), which is the major determinant for clopidogrel treatment responses. Therefore, SNP detection essential predicting efficacy. Currently, there still no quick and effective method routine of common SNPs in clinical laboratories, critically needed prior to treatment. AllGlo™ based quantitative PCR was used develop a novel genotyping detection, termed CyPAllGlo. The performance CyPAllGlo compared with that commonly...

Abstract Clear cell renal carcinoma (ccRCC) is a common malignant tumor, and the role of carbohydrate sulfotransferase 11 (CHST11) in this cancer remains unclear. Here, by using bioinformatics methods, we comprehensively analyzed relationship between CHST11 clinical significance, immune infiltration, functional enrichment, m 6 A methylation, protein–protein interaction networks. We found that expression was significantly higher ccRCC samples than normal tissues. Additionally, levels...

Colon adenocarcinoma (COAD) is one of the most serious cancers. It important to accurately predict prognosis and provide individualized treatment. Evidence suggests that clinicopathological features immune status body are related occurrence development cancer. Expression long non-coding RNA (LncRNA) ALMS1 intronic transcript 1 (ALMS1-IT1) observed in some cancer types, we believe it may have potential serve as a marker COAD. Therefore, used data obtained from genome atlas (TCGA) database...

Cuproptosis has been reported as a new form of cell death. However, its potential mechanism action in clear renal carcinoma (ccRCC) remains unclear. Therefore, we systematically clarified the role cuproptosis ccRCC and aimed to develop novel signature cuproptosis-related long noncoding RNAs (lncRNA) (CRLs) assess clinical characteristics patients.Gene expression, copy number variation, gene mutation, data for were obtained from The Cancer Genome Atlas (TCGA). CRL was constructed with least...

Necroptosis is an immune-related cell death pathway involved in the regulation of tumor microenvironment (TME). Here, we aimed to explore role necroptosis clear renal carcinoma (ccRCC) and construct a necroptosis-related lncRNA (NRL) model assess its potential association with clinical characteristics immune status. Gene expression profiles data for ccRCC patients were obtained from Cancer Genome Atlas (TCGA). Pearson's correlation, univariate Cox, least absolute shrinkage selection operator...

Abstract Background Based on the upper airway anatomy and joint function parameters examined by ultrasound, a multiparameter ultrasound model for difficult assessment (ultrasound model) was established, we evaluated its ability to predict airways. Methods A prospective case-cohort study of prediction in adult patients undergoing elective surgery with endotracheal intubation under general anesthesia, phantom examination before including hyomental distance, tongue thickness, mandibular...

The potential application value of Long non-coding RNA disrupted in renal carcinoma 1 (DIRC1) has not yet been explored, the purpose this study was to explore relationship between DIRC1 and stomach adenocarcinoma (STAD) based on cancer genome atlas database. Wilcoxon rank sum test, Chi-square Fisher test logistic regression were used evaluate relationships clinical-pathologic features expression. Receiver operating characteristic (ROC) curves describe binary classifier using area under curve...

<title>Abstract</title> <bold>Background: </bold>Interleukin-2 Receptor Subunit Gamma (IL2RG) has been implicated in various cancers, but its role clear cell renal carcinoma (ccRCC) remains unclear. This study aimed to explore IL2RG expression, relationship with -related lncRNAs (IRLs). <bold>Methods:</bold> qRT-PCR and IHC were used assess expression ccRCC tissues lines. Pearson correlation analysis identified IRLs related IL2RG, LASSO regression was applied develop a prognostic model. We...

Interstitial lung disease (ILD) is a rare clinical presentation of primary myelofibrosis (PMF).

摘要: 碳酸盐岩是塔里木盆地塔中低凸起古生界油气勘探的主要目的层,G70井在北斜坡奥陶系深层鹰四段测试获高产工业气流,展示了奥陶系深层广阔的勘探潜力,可以作为塔中低凸起碳酸盐岩下一步的接替领域;围绕油源断裂寻找优质储层仍是奥陶系深层勘探及目标优选的首选,但油源断裂的分布及优质储层展布还需进一步明确.基于塔中三维地震资料、结合单井录井、测井、油气物理性质开展油源断裂分析、储层预测及其主控因素分析. 研究结果表明:塔中Ⅰ号断裂东西两端、塔中10号逆断裂西段及编号F1~F16的北东向走滑断裂是奥陶系油气成藏可靠的油源断裂;古岩溶地貌相对稳定区,大面积及长时间的水-岩接触,利于岩溶洞穴储层的发育;后期走滑断裂的活动,导致岩溶作用增强或优化储层性能,在断裂与古岩溶地貌稳定区的叠合区更利于发育优质的岩溶洞穴储层. 在此基础上,结合区域盖层展布、油源断裂展布及优质储层展布特征开展成藏有利区综合评价,优选出11个Ⅰ类有利区带,指明了塔中隆起奥陶系深层下步有利勘探方向. 关键词: 油源断裂 / 储层展布 油气成藏 深层碳酸盐岩 塔中低凸起 石油地质

Abstract Background Esophageal cancer (EC) is a malignant tumor of esophagus with progressive dysphagia as the main clinical manifestation. miRNAs are expected to become potential biomarkers in diagnosis and prognosis EC. Methods Based on AllGlo probes, novel absolute quantitative RT-qPCR method was established detect miRNAs. And significance screened explored 213 patients (166 cases EC 47 benign diseases) 170 normal controls. Results Through series screening, miR-34a-5p, miR-148a-3p...

Abstract Background :The potential application value of LncRNA DIRC1 has not yet been explored, and the purpose this study was to explore relationship between Stomach adenocarcinoma (STAD) based on The Cancer Genome Atlas (TCGA) database. Methods: Wilcoxon rank sum test, Chi-square Fisher test logistic regression were used evaluate relationships clinical-pathologic features expression.Receiver operating characteristic(ROC) curves describe binary classifier using area under curve (AUC)...

Abstract Purpose: To investigate Hidden blood loss (HBL) and its potential risk factors in adolescent idiopathic scoliosis patients undergoing posterior spinal fusion surgery elucidate the influence of HBL on postoperative transfusion. Methods : We retrospectively studied 765 spine for from January 2014 to December 2018. The patient’s demographics, related parameters, operation information were extracted. association between characteristics was analyzed by Pearson or Spearman correlation...