A5100414389- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Ginkgo biloba and Cashew Applications
- Sinusitis and nasal conditions
- Cancer Research and Treatments
- Asthma and respiratory diseases
- Plant-based Medicinal Research
- RNA Research and Splicing
- Phytase and its Applications
- Autophagy in Disease and Therapy
- Cancer Diagnosis and Treatment
- Morinda citrifolia extract uses
- PI3K/AKT/mTOR signaling in cancer
- Pediatric health and respiratory diseases
- Education and Military Integration
- Protein Degradation and Inhibitors
- Biological and pharmacological studies of plants
- Inflammatory mediators and NSAID effects
- Alzheimer's disease research and treatments
- Mycobacterium research and diagnosis
- Gene Regulatory Network Analysis
- Tea Polyphenols and Effects
Jinshan Hospital of Fudan University
2025
First Affiliated Hospital of Jiangxi Medical College
2024
Nanchang University
2020-2024
Shandong University of Traditional Chinese Medicine
2021-2023
Weatherford College
2022-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2023
Nanjing Medical University
2022
Jilin University
2019-2022
China Pharmaceutical University
2009-2022
First Hospital of Jilin University
2019-2022
BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease spectrum of endotypes. TH2- and TH17-related cytokines are 2 central regulators involved in the inflammation associated CRSwNP.ObjectiveWe sought to investigate interregulation TH2 TH17 pathways Chinese patients CRSwNP.MethodsLevels key factors were measured homogenates polyp tissue obtained from CRSwNP. The relationship these their expression groups classified according IL-5 IL-17 concentrations analyzed....
Gastric cancer is a common malignant tumor. Studies from our laboratory or others have shown that long non-coding RNA (lncRNA) zinc finger antisense (ZFAS)1 often acts as an oncogene. However, the molecular underpinnings of how ZFAS1 regulates gastric remain to be elucidated. Results showed expression was upregulated, and microRNA-200b-3p (miR-200b) downregulated in tissues. MiR-200b overexpression suppressed proliferation, cell cycle process, Wnt/β-catenin signaling cells. Subsequently, we...
Ginkgo biloba is monotypic species native to China and has old, dioecious, medicinally important characteristics. The functional genes related these characteristics have not been effectively explored due a limited number of expressed sequence tags (ESTs) from Ginkgo. To discover novel efficiently understand the development living fossil tree, Ginkgo, we used massive parallel pyrosequencing on Roche 454 GS FLX Titanium platform generate 64 057 ESTs. ESTs combined with 21 590 in genbank were...
China has a long history of planting ginkgo trees, and there are many large old trees in rural urban areas China. Those have aesthetic cultural values play an important role regulating landscape ecological functions. However, the geographical distribution its determinants still unexplored. In this study, we first collected from published references county-level data older than 100-year Then used generalized linear regression random forest models to analyze influence 18 variables representing...
Abstract Background Ulcerative colitis (UC) refers to an intractable intestinal inflammatory disease. Its increasing incidence rate imposes a huge burden on patients and society. The UC etiology has not been determined, so screening potential biomarkers is critical preventing disease progression selecting optimal therapeutic strategies more effectively. Methods microarray datasets of mucosal biopsy were selected from the GEO database, integrated with R language screen differentially...
The Warburg effect, characterized by the shift toward aerobic glycolysis, is closely associated with onset and advancement of tumors, including multiple myeloma (MM). Nevertheless, specific regulatory mechanisms glycolysis in MM its functional role remain unclear. In this study, we identified that growth differentiation factor 15 (GDF15) a glycolytic regulator, GDF15 highly expressed cells patient samples. Through gain-of-function loss-of-function experiments, demonstrated promotes cell...
The current study was undertaken to investigate the potential influence of methylation on miR-362-5p/3p expression and further analyzed their independent prognostic value in cervical adenocarcinoma (ADC) squamous cell carcinoma (SCC) respectively. SiHa CaSki cells were used as vitro model. In silico bioinformatic analysis conducted via combined use Cancer Genome Atlas-Cervical (TCGA-CESC), Starbase 3.0 String 10.5. Results revealed that downregulation accompanied by infection high-risk human...
Abstract Background Aberrant DNA methylation is an epigenetic marker that has been linked to the pathogenesis of colorectal cancer (CRC). Long noncoding RNAs (lncRNAs) have increasingly identified be associated with tumorigenic processes CRC. Identifying epigenetically dysregulated lncRNAs and characterizing their effects during carcinogenesis are focuses research. Methods Differentially methylated loci expressed were by integrating methylome transcriptome analyses using The Cancer Genome...
Abstract Scopoletin is a naturally occurring coumarin compound found in many medicinal plants, such as Erycibe obtusifolia Benth and Aster tataricus . Our previous studies have demonstrated that this could ameliorate adjuvant‐induced arthritis rat model of human rheumatoid (RA). Since the proliferation fibroblast‐like synoviocytes (FLS) plays pivotal role formation growth pannus, which leads to subsequent joint destruction RA, we examined effects scopoletin on FLS apoptosis. Primary from...
Abstract Due to its high proliferation capacity and rapid intracranial spread, glioblastoma (GBM) has become one of the least curable malignant cancers. Recently, competing endogenous RNAs (ceRNAs) hypothesis a focus in researches molecular biological mechanisms cancer occurrence progression. However, there is lack correlation studies on GBM, as well comprehensive analyses GBM based high‐throughput sequencing large‐scale sample sizes. We obtained RNA‐seq data from The Cancer Genome Atlas...
Background. Hepatocellular carcinoma (HCC), ranking as one of the most common malignant tumors, is leading causes cancer death, with a poor prognosis. Cuproptosis, novel programmed cell death modality that has just been confirmed recently, may play an important role in HCC Long noncoding RNA (LncRNA) key participant tumorigenesis and immune responses. It be great significance to predict based on cuproptosis genes their related LncRNA. Methods. The sample data patients were obtained from...
Adenoid hypertrophy (AH) is associated with pediatric chronic rhinosinusitis (pCRS), but its role in the inflammatory process of pCRS unclear. It thought that innate immunity gene expression disrupted epithelium patients (CRS), including antimicrobial peptides and pattern recognition receptors (PRRs). The aim this preliminary study was to detect genes epithelial cells hypertrophic adenoids without better understand their pCRS.Nine nine simple AH undergoing adenoidectomy were recruited for...
RNA-sequencing enables accurate and low-cost transcriptome-wide detection. However, expression estimates vary as reference genomes gene annotations are updated, confounding existing expression-based prognostic signatures. Herein, 9-gene pair signature (GPS) was applied to 197 patients with stage I lung adenocarcinoma derived from previous latest data The Cancer Genome Atlas (TCGA) processed different annotations. For 9-GPS, 6.6% of exhibited discordant risk classifications between the two...
Colon adenocarcinoma (COAD) is one of the most serious cancers. It important to accurately predict prognosis and provide individualized treatment. Evidence suggests that clinicopathological features immune status body are related occurrence development cancer. Expression long non-coding RNA (LncRNA) ALMS1 intronic transcript 1 (ALMS1-IT1) observed in some cancer types, we believe it may have potential serve as a marker COAD. Therefore, used data obtained from genome atlas (TCGA) database...
The potential application value of Long non-coding RNA disrupted in renal carcinoma 1 (DIRC1) has not yet been explored, the purpose this study was to explore relationship between DIRC1 and stomach adenocarcinoma (STAD) based on cancer genome atlas database. Wilcoxon rank sum test, Chi-square Fisher test logistic regression were used evaluate relationships clinical-pathologic features expression. Receiver operating characteristic (ROC) curves describe binary classifier using area under curve...
In order to investigate the potential link between Alzheimer's disease (AD) and chronic kidney (CKD), we conducted a comprehensive analysis using bioinformatics approach. We downloaded AD CKD datasets from Gene Expression Omnibus database analyzed differentially expressed genes weighted gene co-expression networks identify candidate for CKD. used combination of least absolute shrinkage selection operator random forest algorithms select shared genes. Subsequently, performed an immune...
A lack of objective biomarkers is preventing the screening and diagnosis COVID-19 combined with major depression disorder (COVID-19-MDD). The purpose this study was to identify diagnostic gene regulatory mechanisms associated autophagy; a crucial process significantly involved in pathogenesis COVID-19-MDD.In study, differentially expressed genes (DEGs) were screened using GSE98793 from GEO2R analysis (GEO) database, intersected COVID-19-related (CRGs) autophagy-related (ARGs) obtain common...
The etiology of chemically-induced neurotoxicity like seizures is poorly understood. Using reversible induced by two neurotoxicants as example, we demonstrate that a bioinformatics-guided reverse engineering approach can be applied to analyze time series microarray gene expression data and uncover the underlying molecular mechanism. Our results reinforce previous findings cholinergic GABAergic synapse pathways are target carbaryl RDX, respectively. We also conclude perturbations these...
Actin-related protein 2/3 complex subunit 1A (ARPC1A) is implicated in several cancers due to its critical role regulating actin polymerization. However, the exact mechanism of ARPC1A cancer remains unclear. This study aims investigate biological various and regulatory glioblastoma multiforme (GBM). We analyzed expression differences, prognostic value, mutations, immune infiltration, microenvironment, single-cell level correlations cancers. Furthermore, we employed gene set enrichment...
Isocitrate dehydrogenase 1 (IDH1) mutation status is related to the prognosis and immune microenvironment of glioma. Long non-coding ribonucleic acids (lncRNAs) interact with microRNAs (miRNAs), play roles in competitive endogenous RNA (ceRNA) network tumor progression.Data on low-grade glioma (LGG) IDH1 was acquired from The Cancer Genome Atlas (TCGA). An empirical analysis differential gene expression conducted identify differentially expressed mRNAs (DEmRNAs), miRNAs (DEmiRNAs), lncRNAs...