A5101980946- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Synthesis and Catalytic Reactions
- Uterine Myomas and Treatments
- Lipid metabolism and disorders
- Intraperitoneal and Appendiceal Malignancies
- Cancer, Hypoxia, and Metabolism
- Breast Cancer Treatment Studies
- Chemical Reactions and Isotopes
- Intestinal and Peritoneal Adhesions
- Gastric Cancer Management and Outcomes
- Radiopharmaceutical Chemistry and Applications
- RNA modifications and cancer
- Glycosylation and Glycoproteins Research
- Colorectal Cancer Surgical Treatments
- Metastasis and carcinoma case studies
- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Appendicitis Diagnosis and Management
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Cervical Cancer and HPV Research
- Click Chemistry and Applications
- Cancer, Lipids, and Metabolism
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2023
Peking Union Medical College Hospital
2023
Cangzhou Central Hospital
2016-2019
Fujian Medical University
2009
MiR-21 is an important microRNA (miRNA) modulating radiosensitivity of cervical cancer cells. However, the underlying mechanism miR-21 upregulation in radioresistant has not been fully understood. In addition, autophagy may either promote or alleviate radioresistance, depending on types and tumor microenvironment. How affects how involved this process reported. This study showed that related to HIF-1α overexpression. overexpression decreases PTEN, increases p-Akt, subsequently expression,...
Epigenetic modulation is an important mechanism of miRNA dysregulation in cervical cancer. In this study, we firstly studied how contributes to miR-375 downregulation cancer cells. Then, further the association between and MALAT1 (metastasis associated lung adenocarcinoma transcript 1) epithelial mesenchymal transition (EMT) HPV-16 positive SiHa CaSki cells were used as vitro model. Our data showed that E6 positively modulated DNMT1 expression both Knockdown partly restored levels The...
All over the world, most common malignancy in women is breast cancer. Breast cancer also a significant factor of death women. In 2020, approximately 2.3 million cases were newly diagnosed globally, and 685,000 people died. incidence varies by region around but it all increasing. According to current morbidity mortality trend cancer, estimated that 2030, number deaths will reach 2.64 1.7 million, respectively. The age-standardized rate was 66.4/100,000 developed countries 27.3/100,000...
The current study was undertaken to investigate the potential influence of methylation on miR-362-5p/3p expression and further analyzed their independent prognostic value in cervical adenocarcinoma (ADC) squamous cell carcinoma (SCC) respectively. SiHa CaSki cells were used as vitro model. In silico bioinformatic analysis conducted via combined use Cancer Genome Atlas-Cervical (TCGA-CESC), Starbase 3.0 String 10.5. Results revealed that downregulation accompanied by infection high-risk human...
The aim of this study was to identify the biological characteristics and potential roles endometrial progenitor cells in pathogenesis endometriosis. It is generally believed that human endometrium are responsible for rapid regeneration. However, paired eutopic ectopic endometriosis remain unclear. This intends isolate epithelial (EP) mesenchymal stem (eMSCs) from endometria patients, further reveal their features functions respectively. distributions EP eMSCs expression steroid hormone...
Colorectal cancer (CRC) is the third most common malignancy and second deadliest worldwide. Metastasis to liver, metastatic site in CRC, leading cause of death patients with CRC. Hyperlipidemia, which promotes CRC progression metastasis. Hyperlipidemia commonly observed obese often induced by hypernutrition. The underlying mechanism hypernutrition-induced hyperlipidemia promoting liver metastasis remains unclear, there an unmet need for effective low-cost treatments A mouse cecum orthotopic...
Objective: To study the effects of metastasis associated 1 (MTA1) on biological characteristics such as migration, invasion and proliferation gastric cancer (GC) cells. Methods: pSilencer3.1-MTA1-siRNA vector was used to establish human BGC-823 cell lines with constitutive MTA1-knockdown. Boyden, wound healing, clony forming assay 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2H tetrazolium bromide (MTT) were performed identify MTA1-deficiency behaviors cells in vitro. Simultaneously, MTA1...
Objective To investigate the effects of single nucleotide polymorphism of-1195G.>A in promoter COX-2 gene on transcriptional activity pancreatic cancer cell line. Methods The genotypes of-1195AA and-1195GG were deter-mined by polymerase chain reaction-based restriction fragment length (PCR-RFLP).The reporter plasmids with-1195AA constructed and then pan-creatic Aspc-lcancer cells transfected with these two kinds plasmaids. ac-tivity Aspc-1 or-1195GG genotype was tested luciferase report...
Objective: To investigate the safety and feasibility of laparoscopic remedial surgery in patients who didn't reach cure criterion early colorectal cancer after endoscopic resection. Methods: The clinical follow-up data 12 then underwent resection was collected. clinicalpathological features indications were analyzed to evaluate effects surgery. Results: average number lymph nodes node dissection 15 during surgery, 3 them had metastasis. Among with residual cancer, two cases poorly...