A5048771828- Tendon Structure and Treatment
- Influenza Virus Research Studies
- Bone Metabolism and Diseases
- Osteoarthritis Treatment and Mechanisms
- Respiratory viral infections research
- Inflammatory mediators and NSAID effects
- Orthopedic Infections and Treatments
- Shoulder Injury and Treatment
- Cancer, Hypoxia, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Cancer-related Molecular Pathways
- Bee Products Chemical Analysis
- interferon and immune responses
- Fibroblast Growth Factor Research
- Immune Response and Inflammation
- Biomarkers in Disease Mechanisms
- Dupuytren's Contracture and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Antimicrobial Peptides and Activities
- Heterotopic Ossification and Related Conditions
- Proteoglycans and glycosaminoglycans research
- Cytokine Signaling Pathways and Interactions
- vaccines and immunoinformatics approaches
- Osteomyelitis and Bone Disorders Research
- Exercise and Physiological Responses
Southern Medical University
2015-2025
Nanfang Hospital
2018-2025
Hubei Normal University
2018
Abstract Background Hypercholesterolemia increases the risk of tendon pain and rupture. Tendon-derived stem cells (TDSCs) play a vital role in development tendinopathy. Our previous research found that high cholesterol inhibits tendon-related gene expression TDSCs. Whether has other biological effects on TDSCs remains unknown. Methods isolated from female SD rats were exposed to 10 mg/dL for 24 h. Then, cell apoptosis was assessed using flow cytometry fluorescence microscope. RFP-GFP-LC3...
The mechanisms that coordinate the shift from joint homeostasis to osteoarthritis (OA) remain unknown. No pharmacological intervention can currently prevent progression of osteoarthritis. Accumulating evidence has shown subchondral bone deterioration is a primary trigger for overlying cartilage degeneration. We previously found H-type vessels modulate aberrant formation during pathogenesis OA. However, mechanism responsible elevation in OA still unclear. Here, we PDGFR-β expression,...
There is no effective therapy for implant-associated Staphylococcus aureus osteomyelitis, a devastating complication after orthopedic surgery. An immune-suppressive profile with up-regulated programmed cell death 1/programmed ligand 1 (PD-1/PD-L1) was identified based on our transcriptional data (GEO: GSE166522) from mouse model of S. osteomyelitis. PD-1/PD-L1 expression mainly in F4/80
Nasopharyngeal carcinoma (NPC) poses a significant health burden in specific regions of Asia, and some NPC patients have bone metastases at the time initial diagnosis. Bone metastasis can cause pathologic fractures pain, reducing patients' quality life, is associated with worse survival. This study aims to unravel complex role insulin-like growth factor 1 receptor (IGF-1R) metastasis, offering insights into potential therapeutic targets. We assessed IGF-1R expression cells explored its...
BACKGROUND Previous studies demonstrated that tendon-derived stem cells (TDSCs) were vital healing and mRNA expression of anti-inflammatory cytokine IL-6 was significantly upregulated in injured tendons. The aim the present study to investigate effects on TDSCs vitro. MATERIAL AND METHODS isolated from Achilles tendons SD rats co-cultured with various concentrations IL-6. Cell proliferation, cell cycle analysis, quantitative real-time PCR, western blotting statistical analysis used study....
Abstract Clinical studies have indicated that increased serum cholesterol levels raised the risk of tendinopathy in hypercholesterolemia, but effect on tendon‐derived stem cells (TDSCs) and its underlying mechanism not been studied. The purpose this study is to investigate association between vitro vivo, molecular as well. In TDSCs, was assessed by quantitative polymerase chain reaction, western blot analysis, immunofluorescence staining. Intracellular reactive oxygen species (ROS) detected,...
Influenza A viral (IAV) fusion peptides are known for their important role in viral-cell process and membrane destabilization potential which compatible with those of antimicrobial peptides. Thus, by replacing the negatively or neutrally charged residues FPs positively lysines, we synthesized several potent derived from fusogenic (FPs) hemagglutinin glycoproteins (HAs) IAV. The biological screening identified that addition to antibacterial activities, these (pFPs) effectively inhibited...
Staphylococcus aureus (S. aureus) infection-induced osteomyelitis is a great challenge in clinic treatment. Identification of the essential genes and biological processes that are specifically changed mononuclear cells at an early stage S. clinical significance. Based on transcriptional dataset GSE16129 available publicly, bioinformatic analysis was performed to identify differentially expressed caused by infection. ERBB2, TWIST1 NANOG were screened out as most valuable osteomyelitis-related...
Tendon repair follows a slow course of early inflammatory, proliferative and remodeling phases, which commonly results in the failure loss normal biomechanical properties. Previous studies have demonstrated that tendon‑derived stem cells (TDSCs) are vital healing mRNA expression anti‑inflammatory cytokine interleukin (IL)‑10 is significantly upregulated at late inflammatory phase. To explore how IL‑10 may impact tendon healing, present study investigated vitro effects on TDSCs isolated from...
So far, there has been no effective cure for osteoporotic cortical bone, the most significant change in long bone structure during aging and main cause of fragility fractures, because its underlying molecular cellular mechanisms remain largely unknown. We used 3- 15-mo-old mice as well treated with vehicle gefitinib to evaluate structural, cellular, changes bone. found that senescence osteoprogenitors was increased, whereas expression phosphorylated epidermal growth factor receptor (EGFR) on...
Abstract Osteoarthritis (OA), a disease of the entire joint, is characterized by abnormal bone remodeling and coalescent degradation articular cartilage. We have previously found that elevated levels H‐type vessels in subchondral correlate with OA focal adhesion kinase (FAK) critical for vessel formation osteoporosis. However, potential role FAK remains unexplored. Here, we demonstrate p‐FAK level was dramatically following anterior cruciate ligament transection (ACLT) rats. Specific...
Heterotopic ossification (HO) is defined as the generation of pathological ectopic bony structures in soft tissues, but molecular mechanisms tendon HO are not fully revealed. Hedgehog (Hh) signalling reportedly critical hereditary HO. Our study focuses on role Hh formation trauma-induced ossification. In this study, samples healthy tendons and injured from C57BL/6J female mice at 1, 4, 7, 10 weeks after Achilles tenotomy were collected for quantitative real-time polymerase chain reaction...
Abstract Background: Nasopharyngeal carcinoma (NPC) poses a significant health burden in specific Asian regions, with radiotherapy substantially improving early-stage survival. However, bone metastasis remains formidable challenge. This study aims to unravel the complex role of insulin-like growth factor 1 receptor (IGF-1R) NPC metastasis, offering insights into potential therapeutic targets. Methods: We assessed IGF-1R expression cells and explored its correlation metastasis. Experiments...