A5023734392- Lignin and Wood Chemistry
- Advanced Polymer Synthesis and Characterization
- RNA Interference and Gene Delivery
- Pulmonary Hypertension Research and Treatments
- biodegradable polymer synthesis and properties
- Nanoparticle-Based Drug Delivery
- Advanced Cellulose Research Studies
- Carbohydrate Chemistry and Synthesis
- Cancer-related molecular mechanisms research
- Dendrimers and Hyperbranched Polymers
- Glycosylation and Glycoproteins Research
- Proteoglycans and glycosaminoglycans research
- Orthopedic Infections and Treatments
- Nitric Oxide and Endothelin Effects
- Airway Management and Intubation Techniques
- Polymer composites and self-healing
- Immune Response and Inflammation
- Thermoregulation and physiological responses
- Cancer, Stress, Anesthesia, and Immune Response
- Chemical synthesis and alkaloids
- Cancer therapeutics and mechanisms
- Hydrogels: synthesis, properties, applications
- Alkaloids: synthesis and pharmacology
- Insect Utilization and Effects
- Plant Physiology and Cultivation Studies
Hubei University of Technology
2014-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Southern Medical University
2020-2025
Nanfang Hospital
2020-2025
Guangdong Academy of Medical Sciences
2012-2025
Guangdong Provincial People's Hospital
2020-2025
Shanghai Institute of Materia Medica
2025
Peking Union Medical College Hospital
2020-2025
Academy of Medical Sciences
2020-2025
Seventh People's Hospital of Shanghai
2021-2024
There is no effective therapy for implant-associated Staphylococcus aureus osteomyelitis, a devastating complication after orthopedic surgery. An immune-suppressive profile with up-regulated programmed cell death 1/programmed ligand 1 (PD-1/PD-L1) was identified based on our transcriptional data (GEO: GSE166522) from mouse model of S. osteomyelitis. PD-1/PD-L1 expression mainly in F4/80
Polyaspartamide-based disulfide-containing brushed polyethylenimine derivatives P(Asp-Az)X-SS-PEIs were synthesized via click chemistry and evaluated as nonviral gene delivery carrier. First, azide-functional poly(aspartic acid) with various azide-group densities monoalkyne-terminated PEI disulfide linkages synthesized. Then, reaction between the derivative main chain branched resulted in high-molecular-weight derivative. The structure of obtained polymers was confirmed by (1)H NMR FTIR. It...
The development of novel thermo-, pH- and reduction-sensitive polymeric micelles based on a block copolymer p(PEG-MEMA-co-Boc-Cyst-MMAm-co-VI)-b-PEG (PPBV) for the intracellular delivery anticancer drugs is reported. pH/temperature-responsive behaviour PPBV observed by both DLS UV-Vis experiments. prepared quick heating process are stable in PBS (pH 7.4, 37 °C) over 48 h presence serum at least 12 h. Paclitaxel (PTX) was loaded into with high encapsulation efficiency (>85%), resulting drug...
Right ventricular (RV) dysfunction is the main determinant of mortality in patients with pulmonary arterial hypertension (PAH) and while inflammation pathogenic PAH, there limited information on role RV PAH. Sulforaphane (SFN), a potent Nrf2 activator, has significant anti-inflammatory effects facilitates cardiac protection preclinical diabetic models. Therefore, we hypothesized that SFN might play comparable reducing injury murine PAH model. We induced using SU5416 10% hypoxia (SuHx) for 4...
Abstract Background Thoracoscopic surgery has greatly alleviated the postoperative pain of patients, but postsurgical acute and chronic still exists needs to be addressed. Indwelling drainage tubes are one leading causes after thoracic surgery. Therefore, aim this study was explore effects alternative on video-assisted thoracoscopic (VATS). Methods Ninety-two patients undergoing lung wedge resection were selected randomly assigned conventional chest tube (CT) group 7-Fr central venous...
In recent years, hydrogel beads and in situ hydrogels have gained wide attention various fields such as biomedicine. this study, 3-(4-hydroxyphenyl) propionic acid (HP) was introduced into the side chain of poly(α,β-[N-(2-hydroxyethyl)-D,L-aspartamide]) (PHEA) to synthesize phenolic hydroxyl-functionalized poly(aspartamide) derivative PHEA-HP with enzyme-catalyzed cross-linking potential. First, chemical structure characterized by FT-IR, UV 1H NMR, results vitro cytotoxicity against L929...
Objective: We further explored the anxiolytic and antidepressant effects of scopolamine on perioperative anxiety depression in a high-risk population. Design: randomised controlled study. Setting: tertiary hospital. Population: 583 gynaecological surgical patients were enrolled based inclusion exclusion criteria. Methods: assessed preoperative using Hospital Anxiety Depression Scale (HADS). Patients with symptoms randomly assigned to group (0.3 mg intravenous injection, iv.) or placebo...
The first total synthesis of (±)-tuaimenal A was achieved in six steps starting from sesamol, with an overall yield 26.4%. key transformation a tandem pyridine-catalyzed condensation/6π-electrocyclization sequence, which efficiently constructed the 2H-benzopyran core. Chiral resolution racemate accomplished by using Boc-d-Phe-OH as chiral auxiliary. Enzymatic inhibition assays revealed that both (+)-tuaimenal and its enantiomer exhibited comparable inhibitory activity against SARS-CoV-2...
To explore the association between perioperative SARS-CoV-2 infection and postoperative complications during breakout of Omicron epidemic wave. Observational retrospective cohort study. Multivariable logistic regression was performed to duration from surgery COVID-19 diagnosis likelihood complications. A general hospital in China. 7927 patients aged 18 years older who underwent surgical treatment 1 December 2022 28 February 2023. The outcome a composite adverse events that occurred within...
Novel pH and reduction dual-sensitive biodegradable polymeric micelles for efficient intracellular delivery of anticancer drugs were prepared based on a block copolymer methyloxy-poly(ethylene glycol)-b-poly[(benzyl-l-aspartate)-co-(N-(3-aminopropyl) imidazole-l-aspartamide)] [mPEG-SS-P(BLA-co-APILA), MPBA] synthesized by combination ring-opening polymerization side-chain reaction. The pH/reduction-responsive behavior MPBA was observed both dynamic light scattering UV–vis experiments....
The temperature responsive PEGylated polyaspartamide derivative, denoted as mPEG-PAAHP, was synthesized by the click reaction. FTIR and 1H NMR were adopted to characterize confirm chemical structures of obtained mPEG-PAAHPs. behavior investigated transmittance dynamic light scattering showed that some mPEG-PAAHPs exhibited obvious responsiveness could be used prepare nanoparticles quickly heating. Drug paclitaxel can encapsulated into mPEG-PAAHP based with a high encapsulation efficiency up...
Long non-coding RNAs (lncRNAs) are a class of with the length exceeding 200 base pairs (bps), which do not encode proteins, nevertheless, lncRNAs have many vital biological functions. A large number novel transcripts were discovered as result development high-throughput sequencing technology. Under this circumstance, computational methods for lncRNA prediction in great demand. In paper, we consider global sequence features and propose stacked ensemble learning-based method to predict from...
A novel series of benzothiazole derivatives bearing the ortho ‐hydroxy‐ N ‐acylhydrazone moiety were designed, synthesized, and evaluated for their procaspase‐3 kinase activation activities antiproliferative against five cancer cell lines (NCI‐H226, SK‐N‐SH, HT29, MKN‐45, MDA‐MB‐231). Most target compounds showed moderate to excellent cytotoxic activity all tested lines. The most promising compound 18e (procaspase‐3 EC 50 = 0.31 µM) with IC values ranging from 0.24 0.92µM was 4.24–12.2 times...
This study evaluates and compares the feasibility safety of application laryngeal mask airway (LMA) endotracheal intubation (ETT) for anaesthesia in adult patients undergoing thoracoscopic surgery.Sixty with pectus excavatum (PE) video-assisted surgery NUSS procedure (VATS-NUSS) between September 2016 March 2017 were selected randomly separated into two groups different methods management. In one group, LMA was applied general anaesthesia, other ETT used. The clinical parameters before,...
Effective management of infectious osteomyelitis relies on timely microorganism identification and appropriate antibiotic therapy. Extracellular vesicles (EVs) carry protein genetic information accumulated rapidly in the circulation upon infection. Rat models infected by Staphylococcus aureus (S. aureus), epidermidis epidermidis), Pseudomonas aeruginosa (P. aeruginosa) Escherichia coli (E. coli) were established for present study. Serum EVs isolated three days after The size number serum...