A5005876074- Influenza Virus Research Studies
- Respiratory viral infections research
- Cardiovascular Conditions and Treatments
- Immune Response and Inflammation
- Sulfur Compounds in Biology
- Congenital Heart Disease Studies
- RNA and protein synthesis mechanisms
- Natural product bioactivities and synthesis
- Folate and B Vitamins Research
- Nitric Oxide and Endothelin Effects
- Pharmacological Effects of Natural Compounds
- Mycobacterium research and diagnosis
- Neonatal Health and Biochemistry
- Electron Spin Resonance Studies
- Neuroscience of respiration and sleep
- Bioactive Compounds and Antitumor Agents
- interferon and immune responses
- Reconstructive Facial Surgery Techniques
- Amino Acid Enzymes and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Diphtheria, Corynebacterium, and Tetanus
- Genomics, phytochemicals, and oxidative stress
- Synthesis and biological activity
- Cardiac Ischemia and Reperfusion
- Milk Quality and Mastitis in Dairy Cows
Jinan University
2017-2022
Children's Hospital
2022
Maternal and Child Health Care Hospital of Bao'an
2016-2018
Southern Medical University
2013-2017
Key Laboratory of Guangdong Province
2017
Shandong Normal University
2012
Huaihua University
2010-2012
University of South China
2009-2010
Abstract HSF1, a conserved heat shock factor, has emerged as key regulator of mammalian transcription in response to cellular metabolic status and stress. To our knowledge, it is not known whether HSF1 regulates viral transcription, particularly HIV-1 its latent form. Here we reveal that extensively participates HIV critical for reactivation. Mode action studies demonstrated binds the 5′-LTR reactivate recruits family closely related multi-subunit complexes, including p300 p-TEFb. And...
Drug-resistant bacterial infections pose a serious threat to global health, driving the development of novel antibacterial strategies beyond classic antibiotics. Self-assembled polymeric nanoparticles (SANPs) have emerged as promising candidates due their unique structural properties, which enhance membrane interaction, drug loading, and therapeutic accumulation. The diversity tunable properties SANPs provide flexible design platform for applications. However, navigating vast chemical space...
Hydrogen sulfide (H(2)S), produced by cystanthionine-γ-lysase (CSE) in the cardiovascular system, has been suggested to be third gasotransmitter addition nitric oxide (NO) and carbon monoxide (CO). The present study aimed investigate role of H(2)S ischemic postconditioning (IPO) during early period reperfusion. IPO with 6 episodes 10 sec reperfusion followed ischemia (IPO 2') was administered when initiated. Cardiodynamics concentration were measured at 1, 2, 3, 4, 5, 10, 20, 30, 60, 90 120...
Influenza A viral (IAV) fusion peptides are known for their important role in viral-cell process and membrane destabilization potential which compatible with those of antimicrobial peptides. Thus, by replacing the negatively or neutrally charged residues FPs positively lysines, we synthesized several potent derived from fusogenic (FPs) hemagglutinin glycoproteins (HAs) IAV. The biological screening identified that addition to antibacterial activities, these (pFPs) effectively inhibited...
Influenza virus has caused seasonal epidemics and worldwide pandemics, which tremendous loss of human lives socioeconomics. Nowadays, only two classes anti-influenza drugs, M2 ion channel inhibitors neuraminidase respectively, are used for prophylaxis treatment influenza infection. Unfortunately, strains resistant to one or all those drugs emerge frequently. Hemagglutinin (HA), the glycoprotein in envelope, plays a critical role viral binding, fusion entry processes. Therefore, HA is...
3-<italic>O</italic>-β-Chacotriosyl GA–Me<bold>5</bold>was discovered as a novel H5N1 entry inhibitor.
Abstract Background Few studies have investigated the differences in clinical features of patients with mastitis following Corynebacterium kroppenstedtii infection, and most focused on bacterial antimicrobial susceptibility, detection methods therapy. Methodology There were 133 infected by C. between August 2016 September 2019. was identified using mass spectrometry. The demographics, diagnosis, laboratory test results different types combined bacillus effects treatments reducing recurrence...
Hemodynamically significant patent ductus arteriosus (hsPDA) in very low birth weight (VLBW) infants is routinely treated many countries with oral ibuprofen. This study retrospectively assessed whether the risk of cholestatic liver disease (CLD) increased due to ibuprofen administration VLBW infants. A total 122 preterm (26∼32 weeks, weight<1500g) diagnosed (PDA) admitted our neonatal intensive care unit (NICU) between September 2016 August 2018 were included. Sixty-four hs-PDA and received...
A new compound, 16-acetoxycytosporone B (1), along with four known ones, dankasterone (2), (3), 3beta,5alpha,9alpha-trihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (4), and cyclonerodiol oxide (5), were isolated from Phomopsis sp. YM355364, an endophytic fungus of Aconitum carmichaeli. Their structures characterized by spectral analysis. Compound 2 exhibited significant inhibitory activity against influenza A/Thailand/Kan353/2004(H5N1) pseudovirus all IC50 value 3.56 microM. Compounds 1, 2, 4...
Summary 1. Asymmetric dimethylarginine (ADMA) is a well‐known endogenous nitric oxide synthase (NOS) inhibitor. Although it has been shown to be novel risk marker in cardiovascular medicine and chronic kidney disease, we speculated that some states associated with excess of (NO), such as 1‐methyl‐4‐phenylpyridinium ion (MPP + )‐induced neuronal injury, ADMA might protective by limiting the toxic effect high concentrations NO. 2. The aim present study explore protection against MPP ‐induced...
Extrauterine growth restriction (EUGR) in preterm birth infants could have long-term adverse impacts on health. Less is known about the gut microbiota regarding its establishment early life and role infants.A prospective, longitudinal observational study was conducted with 67 a level III neonatal intensive care unit. Clinical information obtained from medical records, fecal samples were collected weekly during hospitalization processed for 16S rRNA gene sequencing.The bacterial profiles...
1. Asymmetric dimethylarginine (ADMA) is a well-known endogenous nitric oxide synthase (NOS) inhibitor. Although it has been shown to be novel risk marker in cardiovascular medicine and chronic kidney disease, we speculated that some states associated with excess of (NO), such as 1-methyl-4-phenylpyridinium ion (MPP+)-induced neuronal injury, ADMA might protective by limiting the toxic effect high concentrations NO. 2. The aim present study explore protection against MPP+-induced apoptosis...
A male preterm infant, who was born at 28 weeks+ 2 of gestational age and diagnosed as hyaline membrane disease (PHMD) hours after birth, given nasal continuous positive airway pressure (nCAPA) therapy, intratracheal instillation poractant alfa injection, intravenous infusion ceftazidime penicillin for infection, caffeine stimulating respiration. On day 4 treatment, the infant′s heart rate reached 160-170 beats/min. It suspected that induced tachycardia, restored when withdrawn. 16,...