A5087423547- Cardiovascular Function and Risk Factors
- Geotechnical Engineering and Underground Structures
- Geotechnical Engineering and Analysis
- Geotechnical Engineering and Soil Stabilization
- Metabolism, Diabetes, and Cancer
- Structural Behavior of Reinforced Concrete
- Adipose Tissue and Metabolism
- TGF-β signaling in diseases
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Grouting, Rheology, and Soil Mechanics
- Seismic Performance and Analysis
- Civil and Geotechnical Engineering Research
- BIM and Construction Integration
- Cardiac Fibrosis and Remodeling
- Antiplatelet Therapy and Cardiovascular Diseases
- Structural Load-Bearing Analysis
- Parathyroid Disorders and Treatments
- Masonry and Concrete Structural Analysis
- Endoplasmic Reticulum Stress and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Concrete Corrosion and Durability
- Innovations in Concrete and Construction Materials
- Blood properties and coagulation
Qilu Hospital of Shandong University
2014-2025
Guangzhou Municipal Engineering Design and Research Institute
2021-2025
Guangzhou University
2024
Shandong University
2008-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2023
Intelligent Health (United Kingdom)
2022
Guangzhou Building Materials Institute
2007-2021
Ministry of Education of the People's Republic of China
2007-2016
Ministry of Education
2013
CBS International Business School
2013
Background/Aims: Adipocyte-derived exosomes (ADEs) stimulate the activation of macrophages and contribute to development insulin resistance. Sonic Hedgehog (Shh) is an exosome-carrying protein stimulates secrete inflammatory cytokines. However, impact ADEs carrying Shh on pro-inflammatory consequently, adipocyte resistance unclear. Methods: 3T3-L1 adipocytes were cultured with high glucose imitate pathogeny isolated from conditioned media via differential ultracentrifugation. We explored...
Trimetazidine, as an anti-ischemic and antioxidant agent, has been demonstrated to have many cardioprotective effects. However, whether early administration of trimetazidine effect on diabetic cardiomyopathy the mechanisms underlying not yet elucidated. We established a type 2 DCM rat model by high-fat diet low-dose streptozotocin. Rats were separated into different groups: control, diabetes, diabetes + (n = 6, each). Cardiac autophagy, cardiac functions, cardiomyocyte apoptosis monitored....
Drilling with prestressed concrete pipe cased piles (DPC piles) introduces a novel methodology in the domains of energy conservation and environmental protection, utilizing nondisturbed, high-strength, diameters ranging from 800 to 1,400 mm. The distinctive construction method intrinsic DPC creates an annular gap, roughly 10 mm thick, between pile shaft's wall drill hole's wall. Grouting within this pile–soil gap constitutes effective strategy recover augment skin friction piles. Although...
The osteogenic environment promotes vascular calcium phosphate deposition and aggregation of unfolded misfolded proteins, resulting in endoplasmic reticulum (ER) stress chronic renal disease (CKD). Controlling ER through genetic intervention is a promising approach for treating calcification. In this study, we demonstrated positive correlation between stress-induced tribble 3 (TRIB3) expression progression calcification human rodent CKD. Increased TRIB3 promoted smooth muscle cell (VSMC) by...
Seismic fragility analysis is an efficient method to evaluate the structural failure probability during earthquake events. Among existing methods, probabilistic seismic demand model (PSDM) and joint (JPSDM) are generally used compute component system fragility, respectively. However, statistical significance behind parameters related current PSDM JPSDM not comparable. Aside from that, when calculating Monte Carlo sampling (MCS) time-consuming. To solve two flaws, in this paper, logarithm...
Abstract Background Exercise rehabilitation is demonstrated to improve the prognosis of patients with coronary heart disease (CHD). Statins, as key medicine lower cholesterol in CHD, result skeletal muscle injury and impair exercise training adaptation. Energy metabolism dysfunction identified potential mechanism underlying statin‐induced injury. In this study, we investigated effects metabolic modulator trimetazidine on energy statin‐associated intolerance. Methods High‐fat fed...
This paper introduces a new prefabricated recyclable double-row piles retaining system for excavations in silty clay ground. Laboratory model test and numerical simulation are conducted to study the behavior upon excavation. The horizontal displacement (δh), Von Mises stress (σM), strain (ε), ground surface settlement (δv), earth pressure systematically investigated. Furthermore, monitoring data of 13 excavation cases supported by presented discussed. experimental results can basically match...
Visceral adiposity contributes to cardiometabolic risk, and visceral index (VAI) had significant correlation with adiposity. We aimed explore whether VAI was associated cardiac structure function assess the impact of cut-off points defining adipose dysfunction (VAD) on severity coronary heart disease (CHD).A total 95 patients CHD were divided into Control (nondiabetic patients) DM group (diabetic patients). Then two groups respectively VAD absent groups. Clinical, echocardiographic artery...
Aims: To determine the expression time courses and high level of Vip2A(c) Vip1A(c) in Bacillus thuringiensis, survey their insecticidal toxicity spectrum. Methods Results: A kind new vegetative toxin genes encoded by a single operon from B. thuringiensis had been cloned sequenced. The individual genes, 5-terminus truncated were respectively expressed Escherichia coli. Only N-terminus deleted proteins could be purified Ni-NTA agarose, while others processed N-terminal signal peptides cleaved....
STAMP2 is a counterregulator of inflammation and insulin resistance. The aim this study to investigate whether activation improves resistance by regulating macrophage polarization in adipose tissues. diabetic ApoE−/−/LDLR−/− mouse model was induced high-fat diet low-dose streptozotocin. Samples were obtained from epididymal, subcutaneous brown Infiltration M1/M2 macrophages inflammatory cytokines investigated immunohistochemistry. We then used gene overexpression the effect on infiltration...
We demonstrated previously that the activation of ALK7 (activin receptor-like kinase-7), a member type I receptor serine/threonine kinases TGF-β superfamily, resulted in increased apoptosis and reduced proliferation through suppression Akt signaling Smad2-dependent pathway pancreatic β-cells. Here, we show Nodal activates regulates β-cell apoptosis. detected expression clonal lines rodent islet Induction by treatment with high glucose, palmitate, or cytokines significantly INS-1 β-cells...