A5101432926- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Photoacoustic and Ultrasonic Imaging
- Advanced Neuroimaging Techniques and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- Renal cell carcinoma treatment
- Spine and Intervertebral Disc Pathology
- Esophageal Cancer Research and Treatment
- Genetic factors in colorectal cancer
Southern Medical University
2019-2025
Nanfang Hospital
2019-2025
Southeast University
2020-2025
Academy of Military Medical Sciences
2024
Imaging Center
2024
Washington State University Spokane
2024
Georgia Highlands College
2024
Fujian Provincial Cancer Hospital
2024
Fujian Medical University
2024
Sichuan University
2024
Chemotherapy is still one of the principal treatments for gastric cancer, but clinical application 5-FU limited by drug resistance. Here, we demonstrate that ferroptosis triggered STAT3 inhibition may provide a novel opportunity to explore new effective therapeutic strategy cancer and chemotherapy We find negative regulation (FNR) signatures are closely correlated with progression chemoresistance cancer. FNR associated genes (GPX4, SLC7A11, FTH1) upregulated in resistant cells xenografts....
Constitutive activation of signal transducer and activator transcription 3 (STAT3) is a common feature in human non-small cell lung cancer (NSCLC).STAT3 plays an important role progression as driver oncogene acquired resistance targeted therapies alternatively activated pathway.W2014-S with pharmacophore structure imidazopyridine, which was firstly reported to be utilized STAT3 inhibitor discovery, screened out potent from library small molecules.The aim this study investigate the antitumor...
Exosomes contain a wealth of proteomic information, presenting promising biomarkers for the noninvasive early diagnosis diseases, especially cancer. However, it remains great challenge to accurately and reliably distinguish exosomes secreted from different types cell lines. Fluorescence immunoassay is frequently used exosome detection. Nonspecific adsorption in immunoassays unavoidable affects reliability assay results. Despite fact that various methods have been proposed reduce nonspecific...
Umbilical cord mesenchymal stem cells (UCMSCs) have been identified as a potentially ideal cell type for use in regenerative therapeutic contexts owing to their excellent paracrine secretory abilities and other desirable properties. Previous work has shown that cell-derived exosomes can effectively reduce skin aging, but few studies specifically focused on the role of UCMSC-derived this context. In study, we isolated derived from UCMSCs grown three-dimensional culture system explored ability...
Abstract Objective Non‐small cell lung cancer (NSCLC) is a prevailing LC characterized by poor outcomes. AlkB homolog 5 (ALKBH5) functions as tumor suppressor in several cancers. This study delved into the role of ALKBH5 NSCLC development. Methods TCGA database predicted expression patients. levels and human bronchial epithelial cells were determined. pcDNA3.1‐ALKBH5/NC, pcDNA3.1‐SLC7A11/NC, ferrostatin‐1 used to explore interactions among ALKBH5, SLC7A11, ferroptosis. SLC7A11 mRNA its...
A surface-enhanced Raman scattering (SERS) aptasensor based on a hydrophobic assembled nanoacorn (HANA) was developed with improved reproducibility and reduced nonspecific binding effect. In the fabrication process, hexagonal-packed gold film over nanosphere (AuFON) arrays first obtained used as plasmonic substrate. Then, uniform sub-3 nm molecular spacer array (containing reporters) prepared by patterning nanometric hydrophilic ultrathin patches onto AuFON, in which thin layer is composed...
Ferroptosis plays an important role in radiotherapy (RT), and the induction of ferroptosis can effectively sensitize radiotherapy. However, therapeutic efficiency is always affected by resistance, especially SLC7A11 (Solute Carrier Family 7 Member 11)-cystine-cysteine-GSH (glutathione)-GPX4 (glutathione peroxidase 4) pathway-mediated resistance. In this study, tumor-microenvironment self-activated high-Z element-containing nanoferroptosis inducers, PEGylated Fe–Bi–SS metal–organic frameworks...
The present study aimed to investigate the underlying role of interferon-regulatory factor 2 (IRF2)–inositol polyphosphate-4-phosphatase, type-II (INPP4B) axis in regulation autophagy acute myeloid leukemia (AML) cells. Quantitative real time PCR (QRT-PCR) and western blot were performed determine expression levels IRF2, INPP4B autophagy-related markers AML cell lines. Autophagy was assessed by elevated Beclin-1 expression, conversion light chain 3 (LC3)-I LC3-II, downregulated p62 green...
Abstract Immunotherapy has emerged as an innovative strategy with the potential to improve outcomes in cancer patients. Recent evidence indicates that radiation‐induced DNA damage can activate cyclic‐GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) pathway enhance antitumor immune response. Even so, only a small fraction patients currently benefits from radioimmunotherapy due radioresistance and inadequate activation cGAS‐STING pathway. Herein, this work integrates hafnium...
Background: Studies on gadolinium deposition have recently been reported. Objective: The objective of this study was to investigate whether there is an increased magnetic resonance signal intensity (SI) the dentate nucleus (DCN) and quantification (Gd) brain concentrations by inductively coupled plasma-mass spectrometry (ICP-MS) test in rats who had undergone multiple administrations gadoxetic acid gadobutrol. Materials Methods: Sprague–Dawley (24) were equally divided into three groups....
Abstract LncRNA N6-methylandenosine (m6A) modification has been shown to be associated with the constitution of tumor microenvironment (TME) and tumorigenesis. It’s essential understand mechanisms lncRNA m6A in hepatocellular carcinoma (HCC) identify relative prognostic predictors guide therapy explore potential therapeutic targets. Pearson correlation analysis was performed m6A-related lncRNAs 374 patients HCC. Unsupervised cluster lncRNA-based HCC subtypes conducted, followed by concurrent...
Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies and exhibits a high rate relapse unfavorable outcomes. Ferroptosis, relatively recently described type cell death, has been reported to be involved in cancer development. However, prognostic value ferroptosis-related genes (FRGs) AML remains unclear. In this study, we found 54 differentially expressed (DEFRGs) between normal marrow tissues. 18 DEFRGs were correlated with overall survival (OS) (P<0.05). Using...
Exosomal microRNAs (miRNAs) have attracted great attention as predictive and prognostic biomarkers of cancer. Profiling miRNAs plays a key role in the effective diagnosis cancers. However, simultaneous quantification multiple is challenging due to their homology low abundance especially exosomes. Here, we developed sensitive detection method for exosomal with help rolling circle amplification (RCA). In contrast traditional ways, this takes advantages both multiplex sensing ability simplicity...