A5041985747- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Acute Myeloid Leukemia Research
- Ferroptosis and cancer prognosis
- Viral-associated cancers and disorders
- RNA modifications and cancer
- Chronic Myeloid Leukemia Treatments
- Epigenetics and DNA Methylation
- Acute Lymphoblastic Leukemia research
- PI3K/AKT/mTOR signaling in cancer
- Sirtuins and Resveratrol in Medicine
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Autophagy in Disease and Therapy
- Inflammatory Biomarkers in Disease Prognosis
- Heme Oxygenase-1 and Carbon Monoxide
- Genetic factors in colorectal cancer
- Genetic Associations and Epidemiology
- Protein Degradation and Inhibitors
- Hemostasis and retained surgical items
- Chronic Lymphocytic Leukemia Research
- Cancer-related Molecular Pathways
- Lipid metabolism and disorders
- Hematopoietic Stem Cell Transplantation
- Cancer therapeutics and mechanisms
Wenzhou Medical University
2013-2024
First Affiliated Hospital of Wenzhou Medical University
2011-2024
Qinghai No.3 People's Hospital
2024
Guangdong Province Women and Children Hospital
2024
Peking University
2022
Peking University Cancer Hospital
2022
Zhejiang University
2019
First Affiliated Hospital Zhejiang University
2019
It is confirmed that adipose-derived stem cells (ADSCs) transplantation effectively relieves kidney fibrosis and type 2 diabetes disease in mice. Currently, exosome from urine-derived (USCs) can protect 1 diabetes-mediated injury attenuate podocyte damage diabetic nephropathy (DN). Exosome derived USCs has evolved into the strategy for DN treatment, but role of ADSCs-derived (ADSCs-Exo) remains unclear. The present study aimed to investigate therapeutic action molecular mechanism on DN....
5-Fluorouracil (5-FU) has been widely applied to treat various types of cancers, including hepatocellular carcinoma (HCC). However, primary or acquired 5-FU resistance prevents the clinical application this drug in cancer therapy. Herein, our study is first demonstrate that lower expression KRAL, a long non-coding RNA (lncRNA), mediates HCC via miR-141/Keap1 axis. Cell proliferation assays, western blot analysis, qRT-PCR, dual-luciferase reporter assay and immunoprecipitation were performed...
Suppressors of cytokine signaling, SOCS1 and SOCS3, are important negative regulators Janus kinase 2/signal transducers activators transcription which is constitutively activated in myeloproliferative neoplasms (MPNs) leukemia. Curcumin has been shown to possess anticancer activity through different mechanisms. However, whether curcumin can regulate the expression SOCS3 still unknown. Here, we found that elevated via triggering acetylation histone regions promoter K562 HEL cells. As a novel...
It is generally believed that there correlation between cancer prognosis and pretreatment PLR NLR. However, are limited data about their role in diffuse large B cell lymphoma (DLBCL). This study aims to determine the prognostic value of NLR for patients who have DLBCL. The associations clinical characteristics were evaluated among 182 DLBCL from January 2005 June 2016. optimal cutoff values high ( ⩾ 150) 2.32) prediction determined. effect on survival was through multivariate Cox regression...
Abstract Chronic exposure to benzene is known be associated with haematotoxicity and the development of aplastic anaemia leukaemia. However, mechanism underlying benzene‐induced haematotoxicity, especially at low concentrations chronic has not been well‐elucidated. Here, we found that increased autophagy decreased acetylation occurred in bone marrow mononuclear cells ( BMMNC s) isolated from patients exposure. We further showed vitro metabolite, hydroquinone HQ ) could directly induce...
// Shujuan Zhou 1 , Fang Huiyao Chen Wei Zhang Yang Yifen Shi Zhouyi Zheng 2 Yongyong Ma Liyuan Tang Jianhua Feng Yu Lan Sun Yi Bin Liang Kang and Songfu Jiang Department of Hematology, The First Affiliated Hospital Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China Hematology oncology, Traditional Chinese Zhuji, Shaoxing, Correspondence to: Jiang, email: 20442947@qq.com Yu, yukang@163.com Keywords: diffuse large B cell lymphoma, red blood distribution width, prognosis, survival...
Allogeneic hematopoietic stem cell transplantation (HSCT) is the only available curative treatment for patients with β-thalassemia major (β-TM). However, problem of finding a suitable sibling donor well-matched human leukocyte antigens still obstacle to curing these patients. With progress in high-resolution HLA typing technology and supportive care, outcomes after allogeneic HSCT from an unrelated (UD) now approach those donors. UD hampered by increased risk graft-versus-host disease...
Abstract Background Iron overload, which is common in patients with haematological disorders, known to have a suppressive effect on haematogenesis. However, the mechanism for this still unclear. The antioxidant curcumin has been reported protect against iron overload-induced bone marrow damage through an as-yet-unknown mechanism. Methods We established overload cell and mouse models. Mitochondrial reactive oxygen species (mROS) levels, autophagy levels SIRT3/SOD2 pathway were examined models...
Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies and exhibits a high rate relapse unfavorable outcomes. Ferroptosis, relatively recently described type cell death, has been reported to be involved in cancer development. However, prognostic value ferroptosis-related genes (FRGs) AML remains unclear. In this study, we found 54 differentially expressed (DEFRGs) between normal marrow tissues. 18 DEFRGs were correlated with overall survival (OS) (P<0.05). Using...
To determine the prognostic value of baseline mean platelet volume (MPV) in diffuse large B-cell lymphoma (DLBCL) patients. We retrospectively analyzed 161 DLBCL patients who received R-CHOP chemotherapy. The associations between MPV and clinicopathological factors were assessed. A low (MPV ≤ 9.1 fl, cut-off was calculated by receiver operating characteristics) not associated with any other factors. Patients fl experienced a shorter progression-free survival (PFS) (2-year PFS rate, 60.6% vs...
We retrospectively analyzed LMR at diagnosis and completion of first-line therapy prognosis in173 patients with DLBCL from 2005 to 2016. found that an < 3.2 diagnosis, as well therapy, had significantly lower PFS OS rates than those ≥ (P<0.05). Patients recovered the low level showed superior overall survival (OS) (P=0.000) progression-free (PFS) (P=0.001) compared who failed achieve a higher value therapy. The multivariate analysis demonstrated values did not increase upon were independent...
Dysfunction of histone acetylation inhibits topoisomerase IIα (Topo IIα), which is implicated in benzene-induced hematotoxicity patients with chronic benzene exposure. Whether deacetylase (HDAC) inhibitors can relieve remains unclear. Here we showed that hydroquinone, a main metabolite benzene, increased the HDAC activity, decreased Topo expression and induced apoptosis human bone marrow mononuclear cells vitro, treatment two inhibitors, namely trichostatin A (TSA) or mixture...
Long non-coding RNAs (lncRNAs), as one common type of RNAs, play a critical role in the tumorigenesis and development hepatocellular carcinoma (HCC). In current study, we aimed to assess correlation between lncRNAs expression levels prognosis HCC patients. A lncRNA-based signature was also developed predict this work. The profiles tissues tumor para-carcinoma were obtained from Cancer Genome Atlas (TCGA) database. prognostic model established by least absolute shrinkage selection operator...
Background: Currently, the optimal maintenance therapy for patients with acute promyelocytic leukemia (APL) who have achieved complete remission (CR) after completing consolidation chemotherapy remains controversial. The comparative effectiveness of all-trans retinoic acid (ATRA) plus arsenic trioxide (As 2 O 3 ) strategy classic ATRA has not been evaluated. In this study, we compared efficacy and toxicity As in low- to intermediate-risk APL reaching first CR induction therapy. Methods: A...
Philadelphia chromosome‑positive acute lymphoblastic leukemia (Ph+ ALL) is regarded as a prognostically unfavorable subgroup, this ALL subgroup has an increased risk of relapse/refractory disease. CD9, which belongs to the tetraspanin membrane proteins, implicated in several pathological processes, including tumor progression. However, role CD9 pathogenesis Ph+ and potential benefit applying CD9‑targeted RNA interference strategies for treatment require further investigation. The aim present...
Activation-induced cytidine deaminase (AID) is one kind of the mutant enzymes, which target regulating immunoglobulin (Ig) gene in Burkitt's lymphoma to initiate class switch recombination (CSR), resulting c-Myc chromosomal translocation. However, it not clear that whether AID induces c-Myc/IgH translocation double-hit (DHL) with In this study, DHL tissues and classical diffuse large b-cell (DLBCL) were compared. The results suggested important value predicting DHL, stronger CSR was observed...
Gut-derived bacteraemia is a major complication in patients with haematological malignancy after chemotherapy.Our study aimed to investigate the role of proton pump inhibitors (PPIs) occurrence gut-derived bacteraemia.We compared data from 92 hospitalized chemotherapy bacteraemia, collected January 2009 July 2015, those contemporaneous, without bacteraemia. We evaluated PPIs use and analysed effects covariates.Patients had significantly higher incidence (69.6%) than that controls (47.8%). Of...
Abstract Regulated cell death (RCD) plays a crucial role in the initiation and progression of tumors, particularly acute myeloid leukemia (AML). This study investigates prognostic importance RCD-related genes AML their correlation with immune infiltration. We combined TCGA GTEx data, analyzing 1,488 genes, to develop predictive model using LASSO regression survival analysis. The model's accuracy was validated against multiple databases, examining infiltration, therapy responses, drug...
BACKGROUND Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) in adults has a poor prognosis with conventional chemotherapy. Treatment tyrosine kinase inhibitors (TKIs) followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT) improved clinical outcomes; however, the relapse rate is still high. Therapeutic options for patients relapsed/refractory (R/R) Ph+ ALL are scarce, very few studies focusing on these patients. Blinatumomab novel bispecific T-cell...