A5100365022- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Peptidase Inhibition and Analysis
- Immune cells in cancer
- Virus-based gene therapy research
- Cancer Mechanisms and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- IL-33, ST2, and ILC Pathways
- Cytomegalovirus and herpesvirus research
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Cancer Cells and Metastasis
- Chemokine receptors and signaling
- Ubiquitin and proteasome pathways
- Cynara cardunculus studies
- Medicinal plant effects and applications
Memorial Sloan Kettering Cancer Center
2022-2025
Anhui Medical University
2010-2025
Kettering University
2025
Zhejiang University
2023-2025
Beijing Proteome Research Center
2022-2024
First Affiliated Hospital of Soochow University
2008-2023
Soochow University
2008-2023
Tongji Hospital
2023
Huazhong University of Science and Technology
2023
Guangxi University of Chinese Medicine
2022
Previous work has indicated that complement is a mediator of ischemia/reperfusion (I/R) injury. To investigate the components responsible for this effect, we examined model renal I/R injury in C3-, C4-, C5-, and C6-deficient mice. We occluded arteries veins (40–58 minutes) and, after reperfusion (0–72 hours), assessed structural functional mice were protected from injury, whereas C4-deficient not protected. treated with antibody to block C5a generation showed no additional protection...
The restoration of tumor suppressor PTEN by synthetic mRNA nanoparticles sensitizes Pten -null or mutated tumors to immune checkpoint blockade therapy.
Abstract Cerebral amyloid β-peptide (Aβ) accumulation resulting from an imbalance between Aβ production and clearance is one of the most important causes in formation Alzheimer’s disease (AD). In order to preserve maintenance homeostasis have a notable AD therapy, achieving method clear up plaques becomes emerging task. Herein, we describe self-destructive nanosweeper based on multifunctional peptide-polymers that capable capturing clearing for effective treatment AD. The recognize bind via...
Cisplatin-based chemotherapy is a widely used first-line strategy for numerous cancers. However, drug resistances are often inevitable accompanied by the long-term use of cisplatin in vivo, significantly hampering its therapeutic efficacy and clinical outcomes. Among others, autophagy induction one most common causes tumor resistance to cisplatin. Herein, self-assembled nanoprodrug platform was developed with synergistic effect RNAi fight against cisplatin-resistant lung cancer. The consists...
We have previously reported that adoptive transfer of tumor-draining lymph node (TDLN) B cells confers tumor regression in a spontaneous pulmonary metastasis mouse model breast cancer. In this study, we identified IL-10-producing within these cells, and found IL-10 removal, either by using IL-10(-/-) TDLN or systemic neutralization IL-10, significantly augmented the therapeutic efficacy adoptively transferred cells. Depletion B-cell transfers increased CTLs activity PBMCs splenic recipient....
Forkhead box P3 (FOXP3) plays an important role in the development and function of CD4(+) regulatory T (Treg) cells. In this study percentage FOXP3(+) Treg cells peripheral blood mononuclear (PBMC) frequency colonic mucosa patients with inflammatory bowel disease (IBD) were investigated.The PBMC was analyzed by flow cytometry. Immunohistochemistry used to examine inflamed mucosa. Real-time polymerase chain reaction Western blot detect expressions FOXP3 mRNA protein mucosal biopsy specimens...
Abstract Dendritic cell (DC)-based vaccine strategies aimed at targeting cancer stem–like cells (CSC) may be most efficacious if deployed in the adjuvant setting. In this study, we offer preclinical evidence that is case for a CSC-DC as tested murine models of SCC7 squamous and D5 melanoma. Vaccination mice with an ALDHhigh after surgical excision established tumors reduced local tumor relapse prolonged host survival. This effect was augmented significantly by simultaneous administration...
Autophagy plays a crucial role in the metabolic process. So far, conventional methods are incapable of rapid, precise, and real-time monitoring autophagy living objects. Herein, we describe an situ intracellular self-assembly strategy for quantitative temporal determination objectives. The intelligent building blocks (DPBP) composed by bulky dendrimer as carrier, bis(pyrene) derivative (BP) signal molecule, peptide linker responsive unit that can be cleaved autophagy-specific enzyme, i.e.,...
Cellular immunotherapeutics aim to employ immune cells as anticancer agents. Ex vivo engineering of dendritic (DCs), the initial role an response, benefits tumor elimination by boosting specific antitumor responses. However, directly activating DCs in is less efficient and therefore quite challenging. Here, we designed a nanoactivator that manufactures through autophagy upregulating directly, which lead high-efficiency antigen presention antigen-specific T generation. The significantly...
Targeted immunomodulation through biomolecule-based nanostructures, especially to dendritic cells (DCs), holds great promise for effective cancer therapy. However, construction of high-performance agonist by mimicking natural ligand activate immune cell signaling is a challenge so far. Here, peptide-based nanoagonist toward CD40 (PVA-CD40) with preorganized interfacial topological structure that activates lymph node DCs efficiently and persistently, achieving amplified therapeutic efficacy...
Intracellular construction of nanoaggregates from synthetic molecules to mimic natural ordered superstructures has gained increasing attention recently. Here, we develop an endogenous stimuli-induced aggregation (eSIA) approach construct functional for sensing and monitoring cellular physiological processes in situ. We design a series thermosensitive polymer–peptide conjugates (PPCs), which are capable constructing cells based on their isothermal phase transition property. The PPCs composed...
Posterior capsule opacification (PCO) is the most common complication after cataract surgery. So far, only method for PCO treatment precisely focused laser However, it causes severe complications such as physical damages and neuron impairments. Here, a nanostructured photothermal ring integrated intraocular lens (Nano-IOLs) reported, in which rim of commercially available IOLs (C-IOLs) decorated with silica coated Au nanorods (Au@SiO2 ), high-efficient prevention The Nano-IOLs capable...
Regulatory T cells (Tregs) display great promise in rheumatoid arthritis (RA) therapy. However, their low number and differentiation rate limit further application the clinics. In present study, we first optimized a combination of IL-2, TGF-β cyclin dependent kinase inhibitor AS2863619 (IL-2/TGF-β/AS), which could induce Tregs with high efficiency vitro. After induced (iTregs) were confirmed to suppress lymphocyte proliferation pro-inflammatory help (Th1 Th17) activation, chitosan-stabilized...
// Yang Xia 1, 2, * , Huimin Tao 3, 8, Yangyang Hu Quanning Chen 4, Xin 5 Leiming 2 Li Zhou 6 Yi Wang Yangyi Bao Shiang Huang 3 Xiubao Ren Steven K. Lundy 7 Fu Dai ** Qiao Alfred E. Chang 1 Department of Surgery, University Michigan, Ann Arbor, USA The No.1 People's Hospital Hefei, China Hubei Province Stem Cell Research & Appling Center, Wuhan Union Hospital, Wuhan, 4 General Tongji University, Shanghai, Oncology, Renmin Biotherapy, Tianjin Cancer Institute and National Clinical Center...
Abstract mRNA‐based non‐immunotherapy applications, instead of vaccines, require a high translational yield without immune activation. However, the intrinsic immunogenicity mRNA therapeutics activates innate immunity, leading to decreased stability, mediocre protein production, and increased safety risks. Substantial efforts have been invested in addressing this challenge, which primarily focuses on engineered structural biochemical modifications molecules their packaging system....
Type I interferons (IFNs) are critical in mediating antitumoral and antiviral responses. However, the roles of IFN IFNAR signaling within tumor microenvironment remain poorly understood. To address this, we utilized a Cre-loxP system to generate IFNAR1 conditional knockout mice, enabling us dissect role innate adaptive immune cells during antitumor responses elicited by immune-stimulating vaccinia viruses. Our first-generation virus, MQ710, was developed deleting E5R, which encodes cGAS...
Prostatic acid phosphatase (PAP) is one of the prostate-related antigens that are applicable to specific immunotherapy for patients with prostate cancer. In this study, we determined whether or not PAP could be a target molecule in nonprostate A variety adenocarcinoma cell lines were examined their expression at mRNA and protein levels by reverse transcription polymerase chain reaction western blot analysis, respectively. Considerable percentages colon, gastric, breast cancer found positive...