A5001580396- Barrier Structure and Function Studies
- Inflammasome and immune disorders
- NF-κB Signaling Pathways
- Gout, Hyperuricemia, Uric Acid
- Microbial Metabolism and Applications
- Inflammatory Bowel Disease
- Pharmacological Effects of Natural Compounds
- Morinda citrifolia extract uses
- Angiogenesis and VEGF in Cancer
- Gut microbiota and health
- Immune Response and Inflammation
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Dietary Effects on Health
- Neuroinflammation and Neurodegeneration Mechanisms
China Agricultural University
2020-2023
Coixol, a plant polyphenol extracted from coix (Coix lachryma-jobi L.var.ma-yuen Stapf), has not been investigated for its anti-inflammatory effect. In this study, using lipopolysaccharide (LPS)-induced macrophage cell model, we observed that coixol can effectively reduce the expression of interleukin (IL)-1β, IL-6, IL-18, tumor necrosis factor (TNF)-α, nitric oxide (NO), inducible synthases (iNOS), and cyclooxygenase (COX)-2, but had no effect on mediator IL-10. Furthermore, found inhibits...
The microvasculature endothelium accurately regulates the passage of molecules across gut-vascular barrier (GVB), which plays an essential role in intestinal immunity.
The progression of chronic colitis is accompanied by an increase in inflammation and intestinal angiogenesis. Kaempferol, a dietary flavonoid, has been shown to exhibit anti-inflammatory anti-angiogenic properties. However, the effect kaempferol not elucidated. present study aimed investigate effects on angiogenesis microflora mice with colitis. dextran sulfate sodium (DSS)-induced mouse model was used this study. 5-aminosalicylic acid (5-ASA) were evaluated histopathology, ELISA, western...
Coix seed is a functional food in the Chinese diet that possesses ability to alleviate ulcerative colitis clinically. However, underlying mechanisms remain ambiguous. In this study, we investigated protective effect of on experimental mice. The mice were randomly divided into four groups: control group, model feed and positive group. maintenance was replaced with 10 days before orally administering 5% (w/v) dextran sulfate sodium drink. As result, alleviated symptoms, maintained complete...