A5101459015- Peptidase Inhibition and Analysis
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Protease and Inhibitor Mechanisms
- Neuroendocrine Tumor Research Advances
- Ferroptosis and cancer prognosis
- Neonatal Respiratory Health Research
- Circular RNAs in diseases
- Neuroblastoma Research and Treatments
- Acute Ischemic Stroke Management
- Bone health and treatments
- Neurological Disease Mechanisms and Treatments
- Cardiac Structural Anomalies and Repair
- Gout, Hyperuricemia, Uric Acid
- Congenital Diaphragmatic Hernia Studies
- Parvovirus B19 Infection Studies
- Amoebic Infections and Treatments
- Migraine and Headache Studies
- Spondyloarthritis Studies and Treatments
- Management of metastatic bone disease
- Renal cell carcinoma treatment
- S100 Proteins and Annexins
- Renal and related cancers
- Epigenetics and DNA Methylation
Sichuan University
2024-2025
West China Second University Hospital of Sichuan University
2024-2025
Xuzhou Medical College
2025
Fudan University
2025
Affiliated Hospital of Southwest Medical University
2021-2024
Southwest Medical University
2021-2023
Puer University
2018-2023
First Affiliated Hospital of Sichuan Medical University
2021-2023
Jiangxi Agricultural University
2023
China Medical University
2021
Bone metastases of malignant tumors significantly threaten the patient survival and quality life. We designed synthesized a novel bisphosphonate radiopharmaceutical [68Ga- or 177Lu-labeled DOTA-Ibandronate(68Ga/177Lu-DOTA-IBA)] for targeted diagnosis treatment bone metastases. This study explored basic biological characteristics 177Lu-DOTA-IBA, guiding clinical translation providing evidence future applications. The control variable method was used to optimize optimal labeling conditions. in...
We designed and synthesized a novel theranostic bisphosphonate radiopharmaceutical ( 68 Ga- or 177 Lu-labeled DOTA-ibandronic acid [ Ga/ Lu-DOTA-IBA]) for bone metastasis. In this study, the dosimetry, safety, efficacy of Lu-DOTA-IBA as metastases were evaluated in patients with malignancy based on images, blood samples, dosimetric analysis.Eighteen metastasis progression under conventional therapies included study. Baseline 99m Tc-MDP SPECT Ga-DOTA-IBA PET/CT performed comparative purposes...
Purpose In this study, DOTA-IBA was radiolabeled with 68 Ga and we determined the optimum labelling conditions assessed biological properties of Ga-DOTA-IBA. We investigated biodistribution Ga-DOTA-IBA in normal animals undertook PET/CT imaging humans. Finally, explored feasibility as a bone agent demonstrated its potential for therapeutic release 177 Lu/ 225 Ac-DOTA-IBA. Methods The controlled variables method used to assess impact on radiochemical purity were investigated. micro-PET/CT...
We have developed a new pharmaceutical, ibandronic acid (IBA), and preliminarily demonstrated that it is an efficient bisphosphonate for the diagnosis treatment of bone metastases. This study aims to examine biodistribution internal dosimetry diagnostic 68 Ga-DOTA-IBA in patients.68 was intravenously injected based on 1.81-2.57 MBq/Kg into 8 patients with Each patient underwent 4 sequential static whole-body PET scans at 0.1, 0.45, 0.8, 1.8 hours after injection. The acquisition time each...
Postnatal respiration requires bulk formation of alveoli that produces extensive surface area for gas diffusion from epithelium to the circulatory system. Alveolar morphogenesis initiates at late gestation or postnatal stage during mammalian development and is mediated by coordination among multiple cell types. Here we show fibroblast-derived Heparan Sulfate Glycosaminoglycan (HS-GAG) essential maintaining a niche supports alveolar modulating both biophysical biochemical cues. Gli1-CreER...
Impaired angiogenesis characterized by the reduced proliferation of pulmonary endothelial cells leads to capillary density in patients with bronchopulmonary dysplasia (BPD). In a mouse model BPD, perinatal hyperoxic injury decreases number recently identified lung stem termed as general (gCap) cells, along specific reduction Ntrk2, which encodes for Tropomyosin receptor kinase B (TrkB), within this subpopulation. Herein, we determine whether TrkB signaling is required gCap cell and hyperoxia...
In the tumor microenvironment, programmed death protein 1 and ligand (PD-L1) signaling pathways help tumors escape immune system. We designed a gallium-68 (68Ga)-labeled small-molecule peptide-targeting PD-L1 used positron emission tomography/computed tomography (PET/CT) to detect dynamically monitor expression level of in tumors. S-Cyclo(ETSK)-SF-NH2 (SETSKSF) is cyclic peptide inhibitor comprising seven amino-acid residues. connected it with chelating agent DOTA, labeled DOTA-SETSKSF,...
Uric acid (UA) is a major contributor to naturally-occurring antioxidant activity and thought have protective effects against neurodegenerative processes. However, UA also implicated as risk factor in vascular, including cerebrovascular, disease. Its association with, role in, dementia its component diseases Alzheimer’s disease (AD) vascular (VaD) remains unclear inconsistently studied. Changes blood lipids, particularly cholesterol measures, been dementias although the relationship or...
We presented a case of 67-year-old man with epigastric discomfort and anorexia for more than 2 months. No abnormal 18F-FDG uptake was found throughout the gastrointestinal tract on PET/CT. The patient enrolled in 68Ga-FAPI PET/CT clinical trial, performed to help detect primary lesion. This examination demonstrated nodular thickening gastric wall an increased greater curvature stomach. Finally, pathological result confirmed diagnosis stromal tumor. highlights that might outperform helping...
The aim of this study was to investigate the effects total variation regularized expectation maximization (TVREM) reconstruction on improving 68Ga-DOTA-TATE PET/CT images compared ordered subset (OSEM) reconstruction.A 17 patients with neuroendocrine tumors who underwent clinical were involved in retrospectively. PET acquired either 3 min-per-bed (min/bed) acquisition time and reconstructed OSEM (2 iterations, 20 subsets, a 3.2-mm Gaussian filter) TVREM (seven penalization factors = 0.01,...
Background Prophylactic medication in clinical detoxification programs for the treatment of overuse headache is still debated. Gastrodin, a main bioactive constituent Rhizoma Gastrodiae , has been applied clinically to treat primary more than 30 years China due its potential analgesic and anti-migraine mechanisms. However, evidence supporting routing use MOH insufficient. The present study aims investigate efficacy tolerability oral gastrodin headache. Methods A multicenter, randomized,...
Exposure to environmental neurotoxins associated with agricultural work, such as pesticides, may be a risk factor for neurodegenerative disorders Alzheimer's (AD) and Parkinson's (PD) diseases. There is strong evidence that exposure the development of PD; AD current equivocal. Several mechanisms are proposed mediate this toxicity, one which oxidative stress. Uric acid (UA) an endogenous antioxidant, low levels also implicated in disease.This study aimed determine whether work was population...
Langerhans cell histiocytosis (LCH) is a rare proliferative histiocytic disorder. It mainly occurs in the pediatric population, whereas it rarely reported adults. Herein, we case of patient with isolated rib LCH, which showed elevated 18F-FDG uptake. Our that PET/CT can be potential tool evaluation LCH.
Wilms tumor is the most common renal malignancy in children, with a survival rate of more than 90%; however, treatment outcomes for certain patient subgroups, such as those bilateral and recurrent diseases, remain significantly below this rate. Therefore, it remains essential to identify new biomarkers develop effective therapeutic strategies. Based on Therapeutically Applicable Research Generate Effective Treatments Gene Expression Omnibus RNA microarray datasets, we have identified eight...
Background: Kidney renal clear cell carcinoma (KIRC) is a common malignant tumor of the urinary system. Surgery preferred treatment option; however, rate distant metastasis high. Mast cells in microenvironment promote or inhibit tumorigenesis depending on cancer type; their role KIRC not well-established. Here, we used bioinformatics approach to evaluate roles mast KIRC. Methods: To quantify abundance based gene sets, single-sample set enrichment analysis (ssGSEA) was utilized analyze three...
Abstract Monoamine oxidase type B inhibitors act in Parkinson’s disease (PD) via potentiation of dopamine, but may also have neuroprotective effects by reducing oxidative damage. Oxidative damage is a feature environmental toxins, including pesticides, that are an established risk factor for PD. Another low circulating uric acid (UA), which relate to UA being the major endogenous antioxidant human body. We undertaken study 192 initial admissions PD general hospital neurology department...
Objective: The purpose of this study was to investigate the role [68Ga]Ga-DOTA-FAPI-04 PET/CT in evaluating ovarian physiological FDG uptake. We also prospect future research. Design: Retrospective study. Setting: Nuclear Medicine Department Affiliated Hospital Southwest Medical University. Sample: female patients who underwent simultaneous [18F]-FDG and examinations University from September 2020 January 2021. Methods: reviewed data 78 scanning within 3 days selected those whose ovaries...
Amidst the rising global burden of neurodegenerative diseases, such as Alzheimer's and Parkinson's there is an urgent need for novel therapeutic strategies to combat these debilitating conditions. These diseases are characterized by progressive neural dysfunction leading cognitive impairments, which current remain palliative at best. Recently, discovery ferroptosis, a cell death mode that different from apoptosis autophagy, has opened new avenues in field research. With in-depth research on...