A5100343916- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- Lipid metabolism and biosynthesis
- Developmental Biology and Gene Regulation
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Hippo pathway signaling and YAP/TAZ
- Kruppel-like factors research
- Liver Disease Diagnosis and Treatment
- Genetics, Aging, and Longevity in Model Organisms
- Sulfur Compounds in Biology
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Plant biochemistry and biosynthesis
- Luminescence Properties of Advanced Materials
- Pluripotent Stem Cells Research
- Metabolism and Genetic Disorders
- Mechanisms of cancer metastasis
- Single-cell and spatial transcriptomics
- Invertebrate Immune Response Mechanisms
- Dental materials and restorations
Peking University
2011-2025
Center for Life Sciences
2014-2025
Sichuan University
2024-2025
Fudan University
2025
West China Second University Hospital of Sichuan University
2025
Beibu Gulf University
2024
Central South University
2014-2024
Shenzhen Bioeasy Biotechnology (China)
2024
Second Affiliated Hospital of Zhejiang University
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Substantial epigenetic resetting during early embryo development from fertilization to blastocyst formation ensures zygotic genome activation and leads progressive cellular heterogeneities1–3. Mapping single-cell epigenomic profiles of core histone modifications that cover each individual cell is a fundamental goal in developmental biology. Here we develop target chromatin indexing tagmentation (TACIT), method enabled genome-coverage profiling seven across mouse embryos. We integrated these...
GSK-3, a component of the canonical Wnt signaling pathway, is implicated in regulation bone mass. The effect small molecule GSK-3 inhibitor was evaluated pre-osteoblasts and osteopenic rats. induced osteoblast differentiation vitro increased markers formation vivo with concomitant mass strength rats.Inactivation glycogen synthase kinase -3 (GSK-3) leads to stabilization, accumulation, translocation beta-catenin into nucleus activate downstream target genes. To examine whether directly...
Abstract The physiological role of Dickkopf-1 (Dkk1) during postnatal bone growth in rodents and adult was examined utilizing an antibody to Dkk1 (Dkk1-Ab) that blocked binding both low density lipoprotein receptor-related protein 6 (LRP6) Kremen2, thereby preventing the Wnt inhibitory activity Dkk1. Treatment growing mice rats with Dkk1-Ab resulted a significant increase mineral because increased formation. In contrast, treatment ovariectomized did not appreciably impact bone, effect...
Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide, and it second leading cause cancer-related mortality. Aquaporin 9 (AQP9) an essential aquaporin in located basolateral membrane hepatocytes, but its roles on HCC has not been completely elucidated. This study investigated regulatory functions AQP9 pathogenesis HCC. The expression levels were significantly down-regulated tissues cells, which was also correlated with tumor size number, TNM stage, five-year...
Oral squamous cell carcinoma (OSCC) stands as a prevalent subtype of head and neck carcinoma, leading to disease recurrence low survival rates. PPARγ, ligand-dependent nuclear transcription factor, holds significance in tumor development. However, the role PPARγ development OSCC has not been fully elucidated. Through transcriptome sequencing analysis, we discovered notable enrichment ferroptosis-related molecules upon treatment with antagonist. We subsequently confirmed occurrence...
Abstract Glaucoma is a leading cause of irreversible blindness worldwide and characterized by progressive retinal ganglion cell (RGC) degeneration vision loss. Since neurodegeneration occurs before diagnosable, early diagnosis effective neuroprotection are critical for glaucoma management. Small extracellular vesicles (sEVs) demonstrated to be potential novel biomarkers therapeutics variety diseases. In this study, it found that intravitreal injection circulating plasma‐derived sEVs (PDEV)...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic worldwide. If left untreated, MASLD can progress from simple hepatic steatosis to metabolic steatohepatitis, which characterized by inflammation and fibrosis. Current treatment options for remain limited, leaving substantial unmet medical needs innovative therapeutic approaches. Here, we show that PLIN2, a lipid droplet protein inhibiting lipolysis, serves as promising target MASLD. Hepatic PLIN2...
In head and neck squamous cell carcinoma (HNSCC) cells, Rap1 shuttles between the nucleus cytoplasm. Prior findings suggested that may modulate beta-catenin-independent Wnt pathway in some settings, but role of beta-catenin-dependent signaling remains undefined.We observed beta-catenin bound to active vitro activated beta-catenin/T-cell factor (TCF)-dependent transcription. Immunofluorescence studies showed ectopic expression increased nuclear translocation beta-catenin. Overexpression...
Tung tree (Vernicia fordii) provides the sole source of tung oil widely used in industry. Lack fatty acid composition and molecular markers hinders biochemical, genetic breeding research. The objectives this study were to determine profiles develop unigene-derived simple sequence repeat (SSR) tree. Fatty 41 accessions showed that ratio α-eleostearic was increasing continuously with a parallel trend amount accumulation while ratios other acids decreasing different stages seeds (18∶3)...
Superwettable microwell arrays were constructed for the first time by synergic photocatalysis of silver-doped-ZnO (Ag-ZnO) nanorods patterned on indium tin oxide (ITO) electrodes electroanalysis glutathione (GSH) in hela cells through signal output AgCl electrochemistry. The newly prepared Ag-ZnO with high dispersed into an octadecyltrichlorosilane (OTS) matrix to be deposited onto ITO substrates, yielding superhydrophobic Ag-ZnO-OTS coatings. Superhydrophilic microwells further created...
Massive Open Online Courses (MOOCs) are used to support professional learning at scale in many countries. The present study examined a MOOC named Flipped Classrooms that was specially designed for in-service teachers China. This offered seven consecutive iterations across three years and allowed re-take this course connection with their teaching practice. Overall, 16% of all 105,370 learners enrolled least two the MOOC. To understand motivations, engagement within MOOC, connections they...
Abstract Background Malnutrition is implicated in human metabolic disorders, including hepatic steatosis and myosteatosis. The corresponding nutrient signals sensors as well signalling pathways have not yet been studied. This study aimed to unravel the nutrient‐sensing mechanisms pathogenesis of steatosis. Methods Plin2, a lipid droplet (LD) protein‐inhibiting lipolysis, associated with liver muscle. Taking advantage Gal4‐UAS system, we used Drosophila melanogaster wing imaginal disc an vivo...
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Postnatal respiration requires bulk formation of alveoli that produces extensive surface area for gas diffusion from epithelium to the circulatory system. Alveolar morphogenesis initiates at late gestation or postnatal stage during mammalian development and is mediated by coordination among multiple cell types. Here we show fibroblast-derived Heparan Sulfate Glycosaminoglycan (HS-GAG) essential maintaining a niche supports alveolar modulating both biophysical biochemical cues. Gli1-CreER...