A5082720864- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mycobacterium research and diagnosis
- Immune Response and Inflammation
- Lysosomal Storage Disorders Research
- Calcium signaling and nucleotide metabolism
- Pediatric health and respiratory diseases
- Gut microbiota and health
- Parasites and Host Interactions
- Immune Cell Function and Interaction
- Antimicrobial Peptides and Activities
- Adenosine and Purinergic Signaling
- Tuberculosis Research and Epidemiology
- Dermatology and Skin Diseases
- Immune responses and vaccinations
- Bacterial Infections and Vaccines
- Inflammation biomarkers and pathways
- Medical and Biological Ozone Research
- Escherichia coli research studies
- Plant-Microbe Interactions and Immunity
- Cytomegalovirus and herpesvirus research
- Asthma and respiratory diseases
- Nail Diseases and Treatments
University of Birmingham
2019-2025
Institute of Immunology
2020-2023
Czech Academy of Sciences, Institute of Microbiology
2020-2023
National Institute of Allergy and Infectious Diseases
2015-2022
National Institutes of Health
2014-2022
Glasgow Royal Infirmary
2019
Birmingham City Hospital
2019
Royal Berkshire Hospital
2019
Manchester Academic Health Science Centre
2019
University of Manchester
2019
Clearance of invading microbes requires phagocytes the innate immune system. However, successful pathogens have evolved sophisticated strategies to evade killing. The opportunistic human fungal pathogen Candida albicans is efficiently phagocytosed by macrophages, but causes inflammasome activation, host cytolysis, and escapes after hypha formation. Previous studies suggest that macrophage lysis C. results from early inflammasome-dependent cell death (pyroptosis), late damage due glucose...
Candida is the most common human fungal pathogen and causes systemic infections that require neutrophils for effective host defense. Humans deficient in C-type lectin pathway adaptor protein CARD9 develop spontaneous disease targets central nervous system (CNS). However, how promotes protective antifungal immunity CNS remains unclear. Here, we show a patient with deficiency had impaired neutrophil accumulation induction of neutrophil-recruiting CXC chemokines cerebrospinal fluid despite...
Invasive pulmonary aspergillosis is a life-threatening mycosis that only affects patients with immunosuppression, chemotherapy-induced neutropenia, transplantation, or congenital immunodeficiency. We studied the clinical, genetic, histological, and immunological features of 2 unrelated without known immunodeficiency who developed extrapulmonary invasive at ages 8 18. One patient died age 12 progressive intra-abdominal aspergillosis. The other had presented candidiasis 9, central nervous...
Rationale: The clinical features of patients infected with pulmonary nontuberculous mycobacteria (PNTM) are well described, but the genetic components infection susceptibility not.Objectives: To examine variants in PNTM, their unaffected family members, and a control group.Methods: Whole-exome sequencing was done on 69 white PNTM 18 members. We performed candidate gene analysis using immune, cystic fibrosis transmembrance conductance regulator (CFTR), cilia, connective tissue sets. numbers...
The interaction of microbes with pattern recognition receptors (PRRs) is essential for protective immunity. While many PRRs that recognize mycobacteria have been identified, none essentially required host defense in vivo. Here, we identified the C-type lectin receptor CLECSF8 (CLEC4D, MCL) as a key molecule anti-mycobacterial defense. Clecsf8−/− mice exhibit higher bacterial burdens and increased mortality upon M. tuberculosis infection. Additionally, Clecsf8 deficiency associated...
Candidalysin is a cytolytic peptide toxin secreted by Candida albicans hyphae and has significantly advanced our understanding of fungal pathogenesis. critical for mucosal C infections known to activate epithelial cells induce downstream innate immune responses that are associated with protection or immunopathology during oral vaginal infections. Furthermore, candidalysin activates the NLRP3 inflammasome causes cytolysis in mononuclear phagocytes. However, role driving systemic unknown.
The ability of Candida albicans to cause disease is associated with its capacity undergo morphological transition between yeast and filamentous forms, but the role morphology in colonization dissemination from gastrointestinal (GI) tract remains poorly defined.To explore this, we made use wild-type mutants C. an established model GI colonization, induced following antibiotic treatment mice.Our data reveal that favours form albicans, there constitutive low level systemic colonized mice occurs...
Niemann-Pick disease, type C1 (NPC1) is a neurodegenerative disorder with limited treatment options. NPC1 associated neuroinflammation; however, attempts to therapeutically target neuroinflammation in have had mixed success. We show here that characterized by an atypical microglia activation phenotype. Specifically, Npc1-/- demonstrated altered morphology, reduced levels of lineage markers and shift toward glycolytic metabolism. Treatment 2-hydroxypropyl-β-cyclodextrin (HPβCD), drug...
Candida albicans is normally found as a commensal microbe, commonly colonizing the gastrointestinal tract in humans. However, this fungus can also cause mucosal and systemic infections once immune function compromised. Dectin-1 an innate pattern recognition receptor essential for control of fungal both mice humans; however, its role C. colonization has not been defined. Here, we demonstrate that dectin-1 invasion during infection, with deficiency associating impaired clearance dysregulated...
<h3>Background</h3> Myeloid inhibitory C-type lectin-like receptor (MICL, Clec12A) is a lectin (CLR) expressed predominantly by myeloid cells. Previous studies have suggested that MICL involved in controlling inflammation. <h3>Objective</h3> To determine the role of this CLR inflammatory pathology using Clec12A<sup>−/−</sup> mice. <h3>Methods</h3> mice were generated commercially and primarily characterised collagen antibody-induced arthritis (CAIA) model. Mechanisms progress disease...