A5110662842- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Gut microbiota and health
- HIV-related health complications and treatments
- Tracheal and airway disorders
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- HIV/AIDS Research and Interventions
- Mycobacterium research and diagnosis
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- HIV Research and Treatment
- Air Quality and Health Impacts
- Respiratory viral infections research
- Tuberculosis Research and Epidemiology
- Cystic Fibrosis Research Advances
- Atomic and Subatomic Physics Research
- Immune cells in cancer
- Smoking Behavior and Cessation
- HIV/AIDS oral health manifestations
St. Paul's Hospital
2016-2025
University of British Columbia
2016-2025
St. Paul's Hospital
2016-2025
Health First
2024
McGill University
2024
Parks Victoria
2022-2023
Nephrologisches Zentrum Goettingen
2022-2023
La Jolla Alcohol Research
2022-2023
RELX Group (United States)
2022-2023
Hamilton Health Sciences
2022-2023
Patients with asthma–chronic obstructive pulmonary disease overlap syndrome (ACOS) have been largely excluded from pivotal therapeutic trials and, as a result, its treatment remains poorly defined and lacking firm evidence. To date, there is no universally accepted definition of ACOS, which has made it difficult to understand epidemiology or pathophysiology. Despite many uncertainties, emerging agreement that some the key features ACOS include persistent airflow limitation in symptomatic...
Rationale: The clinical features of patients infected with pulmonary nontuberculous mycobacteria (PNTM) are well described, but the genetic components infection susceptibility not.Objectives: To examine variants in PNTM, their unaffected family members, and a control group.Methods: Whole-exome sequencing was done on 69 white PNTM 18 members. We performed candidate gene analysis using immune, cystic fibrosis transmembrance conductance regulator (CFTR), cilia, connective tissue sets. numbers...
Rationale: Lung dysbiosis promotes airway inflammation and decreased local immunity, potentially playing a role in the pathogenesis of acute exacerbations chronic obstructive pulmonary disease (AECOPD). Objectives: We sought to determine relationship between sputum microbiome at time AECOPD hospitalization 1-year mortality COPD cohort. Methods: used samples from 102 patients hospitalized because AECOPD. All subjects were followed for 1 year after discharge. The profile was assessed through...
Abstract Introduction Coronavirus disease 2019 (COVID-19) is a respiratory infection caused by the severe acute syndrome coronavirus-2 (SARS-CoV-2). This virus uses angiotensin converting enzyme II (ACE-2) as cellular entry receptor to infect lower tract. Because individuals with chronic obstructive pulmonary (COPD) are at increased risk of COVID-19, we determined whether ACE-2 expression in airways was related COPD and cigarette smoking. Methods Using RNA-seq, gene levels bronchial...
Background The role of epigenetic aging in the environmental pathogenesis and prognosis fibrotic interstitial lung disease (fILD) is unclear. We evaluated whether ambient particulate matter ≤2.5 μm (PM 2.5 ) neighbourhood disadvantage exposures are associated with accelerated aging, age adverse clinical outcomes patients fILD. Methods This multicentre, international, cohort study included fILD from University Pittsburgh (UPitt, n=306) British Columbia (UBC, n=170). Five-year PM were...
Sarcopenia is a prominent prognostic indicator in patients with coronary artery disease (CAD). This study aimed to examine the feasibility and preliminary effects of resistance-based exercise intervention CAD sarcopenia. pilot assessor-blinded two-arm randomized controlled trial recruited 40 aged ≥60 years sarcopenia (mean age: 69.1 ± 5.03 years; 52.5% male), assigning them 1:1 ratio either usual care or 12-week (60 minutes/session, 2 sessions/week). The followed an individualized,...
Rationale: Pulmonary nontuberculous mycobacterial (PNTM) disease has increased over the past several decades, especially in older women. Despite extensive investigation, no consistent immunological abnormalities have been found. Using evidence from diseases such as cystic fibrosis and primary ciliary dyskinesia, which mucociliary dysfunction predisposes subjects to high rates of that increase with age, we investigated correlates function PNTM infections healthy control subjects.Objectives:...
Combination antiretroviral therapy (cART) has extended the longevity of human immunodeficiency virus (HIV)-infected individuals. However, this resulted in greater awareness age-associated diseases such as chronic obstructive pulmonary disease (COPD). Accelerated cellular senescence may be responsible, but its magnitude measured by leukocyte telomere length is unknown and relationship to HIV-associated COPD not yet been established. We absolute (aTL) peripheral leukocytes from 231...
Abstract The classical M1/M2 polarity of macrophages may not be applicable to inflammatory lung diseases including chronic obstructive pulmonary disease (COPD) due the complex microenvironment in lungs and plasticity macrophages. We examined macrophage sub-phenotypes bronchoalveolar lavage (BAL) fluid 25 participants with CD40 (a M1 marker) CD163 M2 marker). Of these, we performed RNA-sequencing on each subtype 10 patients using Illumina NextSeq 500. Approximately 25% did harbor or surface...
Rationale: Age-related diseases like chronic obstructive pulmonary disease (COPD) occur at higher rates in people living with human immunodeficiency virus (PLWH) than uninfected populations. Objectives: To identify whether accelerated aging can be observed the airways of PLWH COPD, manifest by a unique DNA methylation signature. Methods: Bronchial epithelial brushings from and without COPD HIV-uninfected adults (N = 76) were profiled for gene expression. We evaluated global Alu LINE-1...