A5102924030- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- HIV Research and Treatment
- vaccines and immunoinformatics approaches
- Immune Response and Inflammation
- Immune cells in cancer
- SARS-CoV-2 and COVID-19 Research
- Estrogen and related hormone effects
- Monoclonal and Polyclonal Antibodies Research
- RNA and protein synthesis mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Influenza Virus Research Studies
- Fungal Infections and Studies
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- S100 Proteins and Annexins
- Diabetes and associated disorders
- Psoriasis: Treatment and Pathogenesis
- interferon and immune responses
- Bacterial Genetics and Biotechnology
- Ferroptosis and cancer prognosis
Baylor Scott & White Health
2025
Baylor Medical Center at Garland
2021-2022
Inserm
2009-2021
Baylor University
2008-2019
Hôpital Albert-Chenevier
2017
Institut de Recherche Vaccinale
2014-2017
Assistance Publique – Hôpitaux de Paris
2017
Baylor Institute for Rehabilitation
2011-2015
Baylor University Medical Center
2009
Molecular Biology Consortium
2002
IL-23 is a heterodimeric cytokine composed of the IL-12p40 "soluble receptor" subunit and novel cytokine-like related to IL-12p35, termed p19. Human mouse exhibit some activities similar IL-12, but differ in their capacities stimulate particular populations memory T cells. Like binds IL-12R IL-12Rbeta1. However, it does not use IL-12Rbeta2. In this study, we identify member hemopoietin receptor family as for IL-23, "IL-23R." IL-23R pairs with IL-12Rbeta1 confer responsiveness on cells...
Abstract We have biologically characterized two new members of the IL-17 cytokine family: IL-17F and IL-25. In contrast to conventional in vitro screening approaches, we activity these molecules by direct vivo analysis compared their function that other family members. Intranasal administration adenovirus expressing IL-17, IL-17C, or resulted bronchoalveolar lavage neutrophilia inflammatory gene expression lung. contrast, intranasal IL-25-expressing IL-25 protein production IL-4, IL-5,...
Abstract The sequence of a novel hemopoietic cytokine was discovered in computational screen genomic databases, and its homology to mouse thymic stromal lymphopoietin (TSLP) suggests that it is the human orthologue. Human TSLP proposed signal through heterodimeric receptor complex consists new member hemopoietin family termed IL-7R α-chain. Cells transfected with both subunits proliferated response purified, recombinant TSLP, induced phosphorylation Stat3 Stat5. TSLPR IL-7Rα are principally...
Antigenic or mitogenic stimulation of T cells induces the secretion an array protein hormones that regulate immune responses. Molecular cloning has contributed strongly to our present understanding nature this regulation. A complementary DNA (cDNA) library prepared from a cloned concanavalin A-activated mouse T-helper cell line was screened for abundant and induction-specific cDNA's. One such randomly chosen cDNA found encode preproenkephalin messenger RNA (mRNA). Preproenkephalin mRNA...
Interleukin 4 (IL-4) and IL-13 share many biological functions. Both cytokines promote growth of activated human B cells induce naive surface immunoglobulin D+ (sIgD+) to produce IgG4 IgE. Here we show that a mutant form IL-4, in which the tyrosine residue at position 124 is replaced by aspartic acid (hIL-4.Y124D), specifically blocks IL-4 IL-13-induced proliferation costimulated anti-CD40 mAbs dose-dependent fashion. A mouse protein (mIL-4.Y119D), antagonizes activity was ineffective. In...
Mouse and human interleukin 2 (IL 2) both cause proliferation of T cells the homologous species at high efficiency. Human IL also stimulates mouse similar concentrations, whereas a lower (sixfold to 170-fold) In contrast, cell stimulating activities B stimulatory factor 1 (interleukin 4; 4) appear be specific over range concentrations tested; we detected no activity 4 on cells, or cells.
Abstract Inflammation affects tumor immune surveillance and resistance to therapy. Here, we show that production of IL1β in primary breast cancer tumors is linked with advanced disease originates from tumor-infiltrating CD11c+ myeloid cells. triggered by cell membrane–derived TGFβ. Neutralizing TGFβ or IL1 receptor prevents progression humanized mouse model. Patients metastatic HER2− display a transcriptional signature inflammation the blood leukocytes, which attenuated after blockade. When...
Efforts aimed at restoring robust immune responses limiting human immunodeficiency virus (HIV)-1 replication therapeutically are warranted. We report that vaccination with dendritic cells generated ex vivo and loaded HIV lipopeptides in patients (n = 19) on antiretroviral therapy was well tolerated immunogenic. Vaccination increased: (i) the breadth of response from 1 (1-3) to 4 (2-5) peptide-pool responses/patient (p 0.009); (ii) frequency functional T (producing least two cytokines among...
Highlights•HIV-1 vaccine-induced broadly neutralizing antibodies targeted the V1V2-glycan site•V1V2-glycan arose when host factors limited CD4 binding site antibodies•V-region secondary rearrangement was a mechanism for generating antibodiesSummaryThe events required induction of broad (bnAbs) following HIV-1 envelope (Env) vaccination are unknown, and their in animal models as proof concept would be critical. Here, we describe plasma capable heterologous primary (tier 2) strains one macaque...
Journal Article Structure of the Escherichia coli S10 ribosomal protein operon Get access Gerard Zurawski, Zurawski DNAX Research Institute Molecular and Cellular Biology901 California Avenue, Palo Alto, CA 94304, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Sandra Marvo Nucleic Acids Research, Volume 13, Issue 12, 25 June 1985, Pages 4521–4526, https://doi.org/10.1093/nar/13.12.4521 Published: 1985 history Received: 05 April Revision received: 20 May...
Dectin-1, a C-type lectin recognizing fungal and mycobacterial pathogens, can deliver intracellular signals that activate dendritic cells (DCs), resulting in initiation of immune responses expansion Th17 CD4(+) T cell responses. In this paper, we studied the roles human Dectin-1 (hDectin-1) expressed on DCs induction activation Ag-specific CD8(+) We first generated an agonistic anti-hDectin-1 mAb, which recognizes hDectin-1 Glu(143)-Ile(162) region. It bound to vitro monocyte-derived vivo...
Dendritic cells (DCs) are major antigen-presenting that can efficiently prime and cross-prime antigen-specific T cells. Delivering antigen to DCs via surface receptors is thus an appealing strategy evoke cellular immunity. Nonetheless, which DC receptor target yield the optimal CD8+ CD4+ cell responses remains elusive. Herein, we report superiority of CD40 over 9 different lectins scavenger at evoking responses. However, (e.g., LOX-1 Dectin-1) were more efficient than eliciting Common...
The etiology of sporadic human chronic inflammatory diseases remains mostly unknown. To fill this gap, we developed a strategy that simultaneously integrates blood leukocyte responses to innate stimuli at the transcriptional, cellular, and secreted protein levels. When applied systemic juvenile idiopathic arthritis (sJIA), an autoinflammatory disease unknown etiology, approach identified gene sets associated with specific cytokine environments activated subsets. During remission off...
Abstract We have recently shown that IL-10 fails to trigger Stat3 and Stat1 tyrosine phosphorylation in freshly isolated human neutrophils. In this study, we report can nonetheless induce the binding of IFN-γ response region or high-affinity synthetic derivative c-sis-inducible element neutrophils been cultured for at least 3 h with LPS. Similarly, ability up-regulate suppressor cytokine signaling (SOCS)-3 mRNA was dramatically enhanced and, as a result, translated into SOCS-3 protein. Since...
Pancreatic islets produce and secrete cytokines chemokines in response to inflammatory metabolic stress. The physiological role of these “isletokines” health disease is largely unknown. We observed that release multiple mediators patients undergoing islet transplants within hours infusion. proinflammatory cytokine interferon-γ–induced protein 10 (IP-10/CXCL10) was among the highest released, high levels correlated with poor transplant outcomes. Transgenic mouse studies confirmed donor...