Guangrong Xie
A5101845135- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Treatment of Major Depression
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- Tryptophan and brain disorders
- Transcranial Magnetic Stimulation Studies
- Vitamin C and Antioxidants Research
- Emotional Intelligence and Performance
- Mental Health Treatment and Access
- Bipolar Disorder and Treatment
- S100 Proteins and Annexins
- Birth, Development, and Health
- Schizophrenia research and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurotransmitter Receptor Influence on Behavior
- Vitamin D Research Studies
- Photoreceptor and optogenetics research
- Personality Disorders and Psychopathology
- Venomous Animal Envenomation and Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child and Adolescent Psychosocial and Emotional Development
- Robotic Path Planning Algorithms
Second Xiangya Hospital of Central South University
2014-2024
Central South University
2014-2024
Sichuan Agricultural University
2023-2024
Zhongda Hospital Southeast University
2023
National Clinical Research
2023
Hunan Institute of Mental Health
2017
Xiangya Hospital Central South University
2007-2010
Changhong (China)
2005
Major depressive disorder (MDD) is common and disabling, but its neuropathophysiology remains unclear. Most studies of functional brain networks in MDD have had limited statistical power data analysis approaches varied widely. The REST-meta-MDD Project resting-state fMRI (R-fMRI) addresses these issues. Twenty-five research groups China established the Consortium by contributing R-fMRI from 1,300 patients with 1,128 normal controls (NCs). Data were preprocessed locally a standardized...
Major depressive disorder (MDD) is known to be characterized by altered brain functional connectivity (FC) patterns. However, whether and how the features of dynamic FC would change in patients with MDD are unclear. In this study, we aimed characterize using a large multi-site sample novel network-based approach. Resting-state magnetic resonance imaging (fMRI) data were acquired from total 460 473 healthy controls, as part REST-meta-MDD consortium. networks constructed for each subject...
Major depressive disorder (MDD) is heterogeneous associated with aberrant functional connectivity within the default mode network (DMN). This study focused on data-driven identification and validation of potential DMN-pattern-based MDD subtypes to parse heterogeneity disorder. The sample comprised 1397 participants including 690 patients 707 healthy controls (HC) registered from multiple sites based REST-meta-MDD Project in China. Baseline resting-state magnetic resonance imaging (rs-fMRI)...
Abstract Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder (MDD), reproducible findings are lacking, probably reflecting mostly small sample sizes and heterogeneity in analytic approaches. To address these issues, Depression Imaging REsearch ConsorTium (DIRECT) was launched. The REST-meta-MDD project, pooling 2428 functional brain images processed with standardized pipeline across all participating sites, has been first effort from DIRECT. In this...
Major depressive disorder (MDD) is a globally prevalent and highly disabling disease characterized by dysfunction of large-scale brain networks. Previous studies have found that static functional connectivity not sufficient to reflect the complicated time-varying properties brain. The underlying dynamic interactions between networks MDD remain largely unknown, it also unclear whether neuroimaging-based are sufficiently robust discriminate individuals with from healthy controls since...
Unwillingness to expend more effort pursue high value rewards has been associated with motivational anhedonia in schizophrenia (SCZ) and abnormal dopamine activity the nucleus accumbens (NAcc). The authors hypothesized that dysfunction of NAcc forebrain regions are involved impaired expenditure decision-making SCZ.A 2 (reward magnitude: low vs. high) × 3 (probability: 20% 50% 80%) event-related fMRI design effort-expenditure for reward task (EEfRT) was used examine neural response 23 SCZ...
Objective: To investigate the relationship between leptin and cytokines in depressed patients. Methods: Thirty-three unmedicated patients (24 female, nine male) with depressive disorder 23 healthy controls (16 seven were assessed for serum levels of interleukin (IL)-6, IL-1β, tumour necrosis factor-α (TNF-α) leptin. Results: Levels IL-6 TNF-α higher than normal controls. There significantly lower also significant differences levels, being female male patients, Conclusions: are important...
We examined the impacts of emotional intelligence and self-leadership on coping with stress, assessing mediating roles that positive affect self-efficacy play in this process. Participants were 575 students at 2 Chinese universities, who completed measures self-leadership, intelligence, self-efficacy, affect. The structural equation model analysis results indicated fully mediated relationship between active coping, as we had predicted. Further, a direct effect coping. However, did not...
Background: Melancholic depression has been viewed as one severe subtype of major depressive disorder (MDD). However, it is unclear whether melancholic distinct changes in brain imaging. We aimed to explore specific or distinctive alterations MDD and the could be used separate from non-melancholic healthy controls. Materials Methods: Thirty-one outpatients with thirty-three thirty-two age- gender-matched controls were recruited. All participants scanned by resting-state functional magnetic...
Despite common dissatisfaction with the syndromic heterogeneity of major depression, investigations into its symptom structure are scarce. Self-worthlessness/inadequacy is a distinctive and consistent depression across cultures.We investigated whether self-worthlessness associated self-blaming attribution-related symptoms or instead an expression reduced positive feelings overall, as would be implied by affect accounts depression.44,161 undergraduate students in Study 1, 215 patients current...
Background. Melancholic depression has been assumed as a severe type of major depressive disorder (MDD). We aimed to explore if there were some distinctive alterations in melancholic MDD and whether the could be used discriminate nonmelancholic MDD. Methods. Thirty-one outpatients with MDD, thirty-three thirty-two age- gender-matched healthy controls recruited. All participants scanned by resting-state functional magnetic resonance imaging (fMRI). Imaging data analyzed network homogeneity...
Melancholic major depressive disorder (MDD) is a network-based brain disorder. However, whether or not changes can be applied to differentiate melancholic (MEL) from non-melancholic (NMEL) MDD remains unclear.Thirty-one MEL patients, 28 NMEL and 32 matched healthy controls (HCs) were scanned using resting-state functional magnetic resonance imaging. Patients assessed by the Chinese version of Snaith-Hamilton Pleasure Scale (SHAPS-C) Temporal Experience (TEPS). Fractional amplitude...