A5101906778- Functional Brain Connectivity Studies
- Atrial Fibrillation Management and Outcomes
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Epilepsy research and treatment
- Cardiac Arrhythmias and Treatments
- Neuroscience and Neuropharmacology Research
- Acute Ischemic Stroke Management
- Bipolar Disorder and Treatment
- Advanced MRI Techniques and Applications
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- Cardiac pacing and defibrillation studies
- Schizophrenia research and treatment
- Child Abuse and Trauma
- High Altitude and Hypoxia
- Cardiac electrophysiology and arrhythmias
- Diet and metabolism studies
- Electroconvulsive Therapy Studies
- Gene Regulatory Network Analysis
- Parvovirus B19 Infection Studies
- Family Dynamics and Relationships
- Fetal and Pediatric Neurological Disorders
- Pluripotent Stem Cells Research
Capital Medical University
2012-2025
Beijing Friendship Hospital
2023-2025
Central South University
2022-2025
Hainan Medical University
2025
Hainan General Hospital
2025
Fujian Medical University
2025
Qilu Hospital of Shandong University
2025
Sichuan University
2020-2024
West China Hospital of Sichuan University
2020-2024
Beijing Anzhen Hospital
2015-2024
Aim We sought to use a regional homogeneity (ReHo) approach as an index in resting-state functional magnetic resonance imaging (fMRI) investigate the features of spontaneous brain activity within default mode network (DMN) patients suffering from bipolar depression (BD). Methods Twenty-six with BD and 26 gender-, age-, education-matched healthy subjects participated fMRI scans. compared differences ReHo between two groups DMN investigated relationships sex, age, years education, disease...
Major depressive disorder (MDD) is heterogeneous associated with aberrant functional connectivity within the default mode network (DMN). This study focused on data-driven identification and validation of potential DMN-pattern-based MDD subtypes to parse heterogeneity disorder. The sample comprised 1397 participants including 690 patients 707 healthy controls (HC) registered from multiple sites based REST-meta-MDD Project in China. Baseline resting-state magnetic resonance imaging (rs-fMRI)...
Aim The extent and specifics regarding cognitive dysfunction in patients with bipolar disorder (BD) or major depressive (MDD) their unaffected first‐degree relatives (FDR) have not been addressed any single study. present study compared the function of BD MDD, FDR, healthy control (HC) individuals. Methods population comprised adults (aged 18–55 years) BD, FDR (children siblings MDD), HC ( n = 105, 109, 85, 95, respectively). Repeatable Battery for Assessment Neuropsychological Status was...
Abstract Aims Patients with atrial fibrillation (AF) have an increased risk of cardiovascular events and dementia, even if anticoagulated. Hypertension is highly prevalent in AF population; however, the optimal blood pressure (BP) target for patients remains unknown. Methods results We conducted subgroup analysis Systolic Blood Pressure Intervention Trial (SPRINT) to examine whether modified treatment effects intensive BP control on cognitive outcomes using Cox proportional hazards...
BACKGROUND Schizophrenia (SZ), a chronic and widespread brain disorder, presents with complex etiology pathogenesis that remain inadequately understood. Despite the absence of universally recognized endophenotype, peripheral blood mononuclear cells (PBMCs) serve as robust model for investigating intracellular alterations linked to SZ. AIM To preliminarily investigate potential pathogenic mechanisms identify novel biomarkers METHODS PBMCs from SZ patients were subjected integrative...
The management of postoperative fluid collections, which refers to the accumulation in peritoneal cavity following pancreaticoduodenectomy, presents significant challenges. However, ultrasonography has emerged as a promising tool for diagnosing and guiding interventions this condition. Ultrasonography offers several advantages, including accessibility, cost-effectiveness, real-time imaging capabilities. It plays crucial role identifying ascitic characterizing their contents, evaluating...
Preeclampsia (PE) is a significant pregnancy complication associated with adverse maternal and fetal outcomes, particularly growth restriction (FGR). Identifying risk factors for FGR in PE patients can facilitate timely management improve neonatal outcomes. This retrospective case-control study analyzed 714 singleton pregnancies complicated by preeclampsia at Fujian Maternity Child Health Hospital from January 2016 to October 2023. Participants were categorized based on the presence of FGR....
Abstract Background Mild fetal ventriculomegaly (VM) is a nonspecific finding common to several pathologies with varying prognosis and is, therefore, challenge in consultation. We aimed perform constant, detailed analysis of prenatal findings postnatal outcomes fetuses early-onset late-onset mild ventriculomegaly, provide new evidence basis perspective for counseling. Methods This retrospective cohort study women diagnosis VM between January 2018 October 2020. The population was divided into...
Mutations in PKD1 or PKD2 gene lead to autosomal dominant polycystic kidney disease (ADPKD). The mechanism of ADPKD progression and its link increased cardiovascular mortality is still elusive.We differentiated patient induced pluripotent stem cells (iPSCs) cardiomyocytes (CMs). electrophysiological properties at the cellular level were analyzed by calcium imaging whole cell patch clamping.The iPSC-CMs had decreased sarcoplasmic reticulum content compared with Control-CMs. Spontaneous action...
Anemia is a common comorbidity in patients with atrial fibrillation (AF). Reports on the association of anemia and adverse events AF, especially from Asia, are limited.Based data Chinese Atrial Fibrillation Registry Study (CAFR), total 18,106 AF enrolled between August 2011 December 2018 had hemoglobin (Hb) values recorded at baseline. Patients were classified into three groups according to Hb levels: 15,606 (86.2%) no group (male Hb≥130 g/L; female Hb≥120 g/L), 1800 (9.9%) mild 110≤Hb<129...
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High-altitude exposure can adversely affect neurocognitive functions; however, the underlying mechanisms remain elusive. Why and how does high-altitude impair functions, particularly sleep? This study seeks to identify molecular markers involved, with goal of forming prevention mitigation strategies for altitude sickness. Using serum proteomics metabolomics, we analyzed blood samples from 23 Han Chinese plain dwellers before after six months work in Tibet. The correlation analysis revealed...
ABSTRACT Major Depressive Disorder (MDD) is common and disabling, but its neuropathophysiology remains unclear. Most studies of functional brain networks in MDD have had limited statistical power data analysis approaches varied widely. The REST-meta-MDD Project resting-state fMRI (R-fMRI) addresses these issues. Twenty-five research groups China established the Consortium by contributing R-fMRI from 1,300 patients with 1,128 normal controls (NCs). Data were preprocessed locally a...
Bipolar disorder's (BD) potential endophenotypes include neurological soft signs (NSS) and neurocognitive disorders (ND). Few research, meanwhile, has coupled NSS ND as combined of BD.This study intends to investigate compare their differences in euthymic patients with bipolar disorder (EBP), unaffected first-degree relatives (FDR), healthy controls (HC). Additionally, search for endophenotypic subprojects construct verify a composite endophenotypic.The subjects were all Han Chinese...
Metabolomic signatures of type 2 diabetes mellitus (T2DM) in Tibetan Chinese population, a group with high burden, remain largely unclear. Identifying the serum metabolite profile T2DM (T-T2DM) individuals may provide novel insights into early diagnosis and intervention. Hence, we conducted untargeted metabolomics analysis plasma samples from retrospective cohort study 100 healthy controls T-T2DM patients by using liquid chromatography-mass spectrometry. The had significant metabolic...
The features of cerebral metabolism associated with loss consciousness in patients temporal lobe epilepsy (TLE) have not been fully elucidated. We aim to investigate the alterations cortical-subcortical impaired awareness seizures (IAS).Regional was measured using fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG PET) TLE-IAS and healthy controls. All had a comprehensive evaluation confirm their seizure origin lateralization. Videos all were viewed rated by at least two...