A5100453484- Animal Nutrition and Physiology
- Ruminant Nutrition and Digestive Physiology
- Fatty Acid Research and Health
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Glycosylation and Glycoproteins Research
- Food Allergy and Anaphylaxis Research
- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Reproductive Physiology in Livestock
- Meat and Animal Product Quality
- Endometriosis Research and Treatment
- Adipose Tissue and Metabolism
- Analytical Chemistry and Chromatography
- Effects of Environmental Stressors on Livestock
- Proteins in Food Systems
- Reproductive System and Pregnancy
- Immune Response and Inflammation
- Mass Spectrometry Techniques and Applications
- Genetic and phenotypic traits in livestock
- Protein Hydrolysis and Bioactive Peptides
- Microbial Metabolites in Food Biotechnology
- Allergic Rhinitis and Sensitization
- Physiological and biochemical adaptations
- Advanced Proteomics Techniques and Applications
Jilin Agricultural University
2015-2025
North China Electric Power University
2025
Duke University
2023-2025
Jilin Province Science and Technology Department
2021-2025
Yangzhou University
2021-2025
Shanghai Jiao Tong University
2024-2025
Fujian Academy of Agricultural Sciences
2025
Jilin Agricultural Science and Technology University
2016-2024
Shanghai First Maternity and Infant Hospital
2022-2024
Institute of Genetics and Developmental Biology
2024
Evidence suggests that the hyperammonemia (HA)-induced neuroinflammation and alterations in serotonin (5-HT) system may contribute to cognitive decline anxiety disorder during hepatic encephalopathy (HE). Probiotics maintain immune homeostasis regulate 5-HT be potential treatment for HA-mediated neurological disorders HE. In this study, we tested efficacy of probiotic Lactobacillus helveticus strain NS8 preventing anxiety-like behavior HA rats. Chronic was induced by intraperitoneal...
Toll-like receptor (TLR)4-mediated signaling has been implicated in tumor cell invasion, survival, and metastasis a variety of cancers. This study investigated the expression biological role TLR4 human breast cancer metastasis. MCF-7 MDA-MB-231 are lines with low high metastatic potential, respectively. Using lipopolysaccharide (LPS) to stimulate cells, mRNA protein increased compared that control cells. activation notably up-regulated matrix metalloproteinase (MMP)-2, MMP-9 vascular...
The primary objective of this study was to evaluate the impact fluid injection viscosity in combination with different volumes and flow rates on subcutaneous (SC) pain tolerance.The a single-center, comparative, randomized, crossover, Phase I 24 healthy adults. Each participant received six injections abdomen area either 2 or 3 mL placebo solution, three viscosities (1, 8-10, 15-20 cP) combined two (0.02 0.3 mL/s). All were performed 50 syringes 27G, 6 mm needles. Perceived assessed using...
Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) targeting HER2, exhibiting significant clinical efficacy in breast cancer (BC) with varying HER2 expression, including HER2-low and HER2-ultralow. However, the precise mechanism underlying its contribution of immune activation these settings remain unclear. Here, we demonstrate that T-DXd HER2-negative BC independent engagement ADC internalization. Instead, activity relies on extracellular proteases, such as cathepsin L...
Radix Codonopsis has been used in traditional Chinese medicine for strengthening the immune system, improving poor gastrointestinal function, treating gastric ulcers and chronic gastritis so on. In present study, an inulin-type fructan CP-A was obtained from roots of pilosula (Franch.) Nannf. its structure confirmed by MS NMR as (2 → 1) linked-β-d-fructofuranose. The protective effects against ethanol-induced acute ulcer rats were intensively investigated. A Lacy assay demonstrated that...
Endometriosis is a common benign disease in women of reproductive age. It has been defined as disorder characterized by inflammation, compromised immunity, hormone dependence, and neuroangiogenesis. Unfortunately, the mechanisms endometriosis have not yet fully elucidated, available treatment methods are currently limited. The discovery new therapeutic drugs improvements existing schemes remain focus research initiatives. Chinese medicine can improve symptoms associated with endometriosis....
Leucine and isoleucine possess antioxidative anti-inflammatory properties. However, their underlying protective mechanisms against oxidative damage remain unknown. Therefore, in this study, the mechanism of leucine H2O2-induced a bovine mammary epithelial cell lines (MAC-T cells) were investigated. Briefly, MAC-T cells exposed or free to H2O2 incubated with different combinations isoleucine. The cellular relative proliferation rate viability, stress indicators, inflammatory factors...
The human adrenal zona fasciculata (ZF) and reticularis (ZR) are responsible for the production of cortisol 19-carbon steroids (often called androgens), respectively. However, gene profiles exact molecular mechanisms leading to functional phenotype ZF ZR still not clearly defined. In present study, we identified transcripts that differentially expressed in ZR.The objective study was compare transcriptome ZR.ZF were microdissected from 10 adrenals. Total RNA extracted ZF/ZR pairs hybridized...
Trans vaccenic acid (TVA; trans-11 18:1) is a positional and geometric isomer of oleic it the predominant trans found in ruminant fats. TVA can be converted into cis-9, conjugated linoleic (c9, t11-CLA), CLA that has many beneficial effects, by stearoyl CoA desaturase 1 (SCD1) mammary gland. The health benefits associated with are well documented, but unclear whether fatty acids (TFAs) from products have healthy effects. Therefore, effects on proliferation MCF-7 human breast adenocarcinoma...
Copper nanoparticles (Cu-NPs) are components in numerous commercial products, but little is known about their potential hazard the marine environments. In this study effects of Cu-NPs and soluble Cu on juvenile Epinephelus coioides were investigated. The fish exposed triplicate to control, 20 or 100 µg L(-1) as either copper sulphate (CuSO4) for 25 days. growth performance decreased with increasing CuSO4 dose, more so than treatment. Both forms exposure inhibited activities digestive enzymes...
Proteins physiologically exist as "proteoforms" that arise from one gene and acquire additional function by post-translational modifications (PTM). When multiple PTMs coexist on single protein molecules, top-down proteomics becomes the only feasible method of characterization; however, most methods have limited quantitative capacity insufficient throughput to truly address proteoform biology. Here we demonstrate can be quantitative, reproducible, sensitive, high throughput. The proteoforms...
OBJECTIVE To evaluate associations of oily and nonoily fish consumption oil supplements with incident type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We included 392,287 middle-aged older participants (55.0% women) in the UK Biobank who were free diabetes, major cardiovascular disease, cancer had information on habitual intake food groups use at baseline (2006–2010). Of these, 163,706 participated one to five rounds 24-h dietary recalls during 2009–2012. RESULTS During a median 10.1 years...