A5101935101- interferon and immune responses
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Nuclear Structure and Function
- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Material Dynamics and Properties
- Mosquito-borne diseases and control
- Protein Tyrosine Phosphatases
- Metallic Glasses and Amorphous Alloys
- Cell death mechanisms and regulation
- Galectins and Cancer Biology
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Inflammasome and immune disorders
- Traditional Chinese Medicine Studies
- Nitric Oxide and Endothelin Effects
- Wnt/β-catenin signaling in development and cancer
- Genetic Syndromes and Imprinting
- Advanced Causal Inference Techniques
- Immune Response and Inflammation
- Cancer Mechanisms and Therapy
University of North Carolina at Chapel Hill
2020-2025
Segeberger Kliniken
2025
UNC Lineberger Comprehensive Cancer Center
2025
Chinese Academy of Sciences
2017-2024
Center for Excellence in Brain Science and Intelligence Technology
2018-2024
Liaoning University
2023
Shanxi Medical University
2017
East China University of Science and Technology
2013-2017
Shanghai Institutes for Biological Sciences
2014-2017
Inner Mongolia Medical University
2015
A novel fluorescent probe for peroxynitrite, PN600, was rationally designed on the basis of a unique fluorophore assembly approach. PN600 is green-emitting coumarin derivative. Upon oxidation by transformed into highly red-emitting resorufin derivative via an orange-emitting intermediate. This three-channel signaling capability enables to differentiate peroxynitrite from other reactive oxygen and nitrogen species, including hypochlorite hydroxyl radical. Moreover, membrane-permeable...
Radix Codonopsis has been used in traditional Chinese medicine for strengthening the immune system, improving poor gastrointestinal function, treating gastric ulcers and chronic gastritis so on. In present study, an inulin-type fructan CP-A was obtained from roots of pilosula (Franch.) Nannf. its structure confirmed by MS NMR as (2 → 1) linked-β-d-fructofuranose. The protective effects against ethanol-induced acute ulcer rats were intensively investigated. A Lacy assay demonstrated that...
Abstract STING is an innate immune sensor for surveillance of viral/bacterial infection and maintenance immune‐friendly microenvironment to prevent tumorigenesis. However, if how exerts immunity‐independent function remains elusive. Here, the authors report that expression increased in renal cell carcinoma (RCC) patients governs tumor growth through non‐canonical signaling involving mitochondrial ROS calcium homeostasis. Mitochondrial voltage‐dependent anion channel VDAC2 identified as a new...
The nuclear import receptor karyopherin β1 (KPNB1) is involved in the of most proteins and regulation multiple mitotic events. Upregulation KPNB1 has been observed cancers including glioblastoma. Depletion induces arrest apoptosis cancer cells, but underlying mechanism not clearly elucidated. Here, we found that downregulation functional inhibition glioblastoma cells induced growth without apparent arrest. upregulated Puma Noxa freed Mcl-1-sequestered Bax Bak, leading to mitochondrial outer...
Chromosomal translocation results in development of an Ewing sarcoma breakpoint region 1-Friend leukemia integration 1 (EWS-FLI1) fusion oncogene the majority sarcoma. The persistent dependence tumor for this oncoprotein points to EWS-FLI1 as ideal drug target. Although transcriptional targets and binding partners are evaluated, mechanisms regulating protein stability remain elusive. Speckle-type POZ (SPOP) OTU domain-containing 7A (OTUD7A) identified bona fide E3 ligase deubiquitinase,...
Significance Deletion or loss-of-function mutations of the maternally inherited allele UBE3A , which encodes an E3 ubiquitin ligase, lead to Angelman syndrome (AS), a developmental neurological disorder with severe intellectual disability. The consequences dysfunction are not well understood. Here, we demonstrate that ubiquitinates PTPA, activator protein phosphatase 2A. Maternal loss Ube3a in AS mouse model leads significant increases PTPA level and PP2A activity. Genetic reduction...
The membrane protein tyrosine phosphatase receptor U (PTPRU) has been shown to function as a negative regulator of adhesion and proliferation in certain cancer cell types, primarily through its dephosphorylation β-catenin inhibition subsequent downstream signaling. In the present study, we set out characterize role PTPRU glioma found that, while expression full-length is low these tumors, number non-full-length isoforms are highly expressed. Among isoforms, one particular localized nucleus,...
Abstract XPO1 (exportin1) mediates nuclear export of proteins and RNAs is frequently overexpressed in cancers. In this study, we show that the orally bioavailable inhibitor KPT-330 reduced Mcl-1 protein level, by which it synergized with Bcl-xL A-1331852 to induce apoptosis cancer cells. KPT-330/A-1331852 combination disrupted bindings Bax, Bak, and/or Bim, elicited mitochondrial outer membrane permeabilization, triggered apoptosis. generally mitigated mRNA expression synthesis rather than...
Ewing sarcoma is a rare pediatric cancer primarily driven by the EWS::FLI1 oncofusion transcription factor. Despite being an ideal drug target, has proven challenging to inhibit with conventional approaches. Recent studies identified ETV6 as vulnerability in sarcoma, where it competes at short GGAA repeats restrain function. However, no therapies targeting have been developed. In this study, we report discovery of unique (GGAA)3 DNA oligonucleotide that specifically binds but not EWS::FLI1....
cGAS/STING signaling plays an essential role in sensing cytosolic DNA. cGAS activity is regulated by posttranslational modifications and binding partners. interactome largely includes mammalian or viral proteins. Whether how bacterial proteins bind to modulate innate immunity remain elusive. Here, we found streptavidin, a secreted protein, selectively bound promote DNA-induced activation interferon-β production. Mechanistically, streptavidin enhanced DNA phase separation, therefore...
Abstract Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine with potential anticancer effect, but innate and adaptive TRAIL resistance in majority of cancers limit its clinical application. Karyopherin β1 (KPNB1) inhibition cancer cells has been reported to abrogate the nuclear import receptor DR5 facilitate localization on cell surface ready for stimulation. However, our study reveals more complicated mechanism. Genetic or pharmacological KPNB1 potentiated...
Constant-pressure molecular dynamics simulations and analysis of the local atomic structures have been performed to study conventional 'inherent' structural evolution liquid Al during rapid solidification. The results show that radial distribution functions g(r) exhibit a second-peak splitting feature not only for general amorphous states but also inherent structure states. second peak decomposes into three main components, each corresponding different pairs. first subpeak in arises from...
Objective: Glioblastomas multiforme (GBM) is the most malignant brain cancer, which presented vast genomic variation with complicated pathologic mechanism.
Oxidized low-density lipoprotein (ox-LDL) is well recognized to play a key role in the development of atherosclerosis. And influenza virus infection has been also promote atherosclerosis onset and progressing. However, little known about mechanism into it. In present study, we investigated A/Porto Rico/8/1934 (H1N1) (PR8) human endothelial Eahy926 cells, determined induction apoptosis by cell. Then induced ox-LDL influence on ox-LDL-induced cells. Results demonstrated that PR8 infected...
Abstract We have successfully measured the internal friction and electrical resistivity of Pd 43 Ni 10 Cu 27 P 20 bulk metallic glass during a constant heating process. The results suggest that position peak is onset temperature crystallization. dependence on frequencies show both linear nonlinear relations. at 623 K in supercooled liquid region decreases monotonously with increase annealing time, indicating structural relaxation subsequent crystallization occurs isothermal near temperature....