A5052767668- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Viral gastroenteritis research and epidemiology
- Microbial Inactivation Methods
- Virus-based gene therapy research
- Advanced Fluorescence Microscopy Techniques
- Ultrasound and Cavitation Phenomena
- Ultrasonics and Acoustic Wave Propagation
- Gold and Silver Nanoparticles Synthesis and Applications
- Flow Measurement and Analysis
- Animal Virus Infections Studies
- Health and Well-being Studies
- Near-Field Optical Microscopy
- Optical Coherence Tomography Applications
- CRISPR and Genetic Engineering
- Plasmonic and Surface Plasmon Research
- Infrared Thermography in Medicine
- Advanced Photocatalysis Techniques
- Microfluidic and Bio-sensing Technologies
- Advanced Optical Sensing Technologies
- Advanced biosensing and bioanalysis techniques
- Viral Infectious Diseases and Gene Expression in Insects
- Animal Disease Management and Epidemiology
- Digital Holography and Microscopy
Sun Yat-sen University
2024-2025
Chongqing University
2025
University of Michigan
2016-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
National Engineering Research Center of Electromagnetic Radiation Control Materials
2024
University of Electronic Science and Technology of China
2023-2024
Institute of Laboratory Animal Science
2011-2024
Michigan United
2018-2024
Xinjiang University
2024
Sichuan University
2019-2024
Abstract In 2011, porcine epidemic diarrhea virus (PEDV) infection rates rose substantially in vaccinated swine herds. To determine the distribution profile of PEDV outbreak strains, we sequenced full-length spike gene from samples 9 farms where animals exhibited severe and mortality were high. Three new variants identified.
Abstract In 2011, porcine epidemic diarrhea virus (PEDV) infection rates rose substantially in vaccinated swine herds. To determine the distribution profile of PEDV outbreak strains, we sequenced full-length spike gene from samples 9 farms where animals exhibited severe and mortality were high. Three new variants identified.
Aqueous Zn ion batteries are promising systems due to their intrinsic safety, low cost, and non-toxicity, the corrosion dendrite growth will cause poor reversibility of anode. Herein, porous Zn@C solid, hollow, yolk-shell microsphere films developed as anode antifluctuator (ZAAF). The prepared microspheres (Zn@C [ZCYSM]) film with superior buffering can effectively restrict deposition metal in its interior inhibit volume expansion during plating/stripping process, thus modulating Zn2+ flux...
Abstract Background High intensity focused ultrasound (HIFU) is an emerging non-invasive treatment modality for localized of cancers. While current clinical strategies employ HIFU exclusively thermal ablation the target sites, biological responses associated with both and mechanical damage from have not been thoroughly investigated. In particular, endogenous danger signals HIFU-damaged tumor cells may trigger activation dendritic cells. This response play a critical role in HIFU-elicited...
A multifunctional NbN-modified separator and an innovative work function chemistry strategy are designed to enhance the durability of ZMBs.
Background A recent study provided evidence that farmed rabbits in China harbor a novel hepatitis E virus (HEV) genotype. Although the rabbit HEV isolate had 77–79% nucleotide identity to mammalian genotypes 1 4, their genomic organization is very similar. Since are used widely experimentally, including as models of infection, we investigated whether they constitute an appropriate animal model for human infection. Methods Forty-two SPF were divided randomly into eleven groups and inoculated...
Quantitative cell motility studies are necessary for understanding biophysical processes, developing models locomotion and drug discovery. Such typically performed by controlling environmental conditions around a lens-based microscope, requiring costly instruments while still remaining limited in field-of-view. Here we present compact monitoring platform utilizing wide-field (24 mm2) lensless holographic microscope that enables automated single-cell tracking of large populations is...
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by mutations in the FMR1 gene that inactivate expression of product, fragile mental retardation 1 protein (FMRP). In this study, we used clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) technology to generate Fmr1 knockout (KO) rats disruption fourth exon gene. Western blotting analysis confirmed FMRP was absent from brains KO (Fmr1exon4-KO ). Electrophysiological revealed...
BackgroundExposure to anesthetics during early life may impair cognitive functions. However, the underlying mechanisms remain largely unknown. We set out determine effects of sevoflurane anesthesia on folate metabolism and myelination in young non-human primates, mice children.MethodsYoung rhesus macaque received 2.5 3% daily for three days. DNA RNA sequencing immunohistochemistry among others were used studies. performed unbiased transcriptome profiling prefrontal cortex macaques after...
Parkinson's disease (PD) is characterized by age-dependent neurodegeneration and the accumulation of toxic phosphorylated α-synuclein (pS129-α-syn). The mechanisms underlying these crucial pathological changes remain unclear. Mutations in parkin RBR E3 ubiquitin protein ligase (PARK2), gene encoding that PTEN-induced putative kinase 1 (PINK1) to participate mitophagy, cause early onset PD. However, current parkin-KO mouse pig models do not exhibit neurodegeneration. In study, we utilized...
The traditional method for calculating acoustic pressure amplitude is to divide a hydrophone output voltage measurement by the sensitivity at working frequency, but this approach neglects frequency dependence of sensitivity. Another perform complex deconvolution between waveform and impulse response (the inverse Fourier transform sensitivity). In paper, effects on measurements peak compressional (p+), rarefactional (p-), pulse intensity integral (PII) are studied. Time-delay spectrometry...
The cytoplasmic accumulation of the nuclear TAR DNA-binding protein 43 (TDP-43) is a pathologic hallmark in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and other neurological disorders. However, most transgenic TDP-43 rodent models show predominant distribution brain. By expressing mutant (M337V) brains rhesus monkeys mice, we verified that distributed cytoplasm monkey brain majority remains nuclei mouse primate-specific caspase-4, but not homologue caspase-11, could...
Abstract Background Experimental animals are used to study physiological phenomena, pathological mechanisms, and disease prevention. The gut microbiome is known as a potential confounding factor for inconsistent data from preclinical studies. Although many studies have been conducted in recent decades, few focused on microbiota fluctuation among representative mouse strains. Methods A range of frequently strains were selected 34 isolation packages representing disease‐related animal (DRA),...
Abstract Bio‐inspired synaptic devices have garnered considerable interest in neuromorphic computing. The Bienenstock‐Cooper‐Munro (BCM) learning rule stands out as one of the most accurate models, featuring non‐monotonic behavior and threshold sliding effect, crucial for stable processes. direct device strategy completely mimicking BCM is a tough issue since current lack two competitive working modes within device. In this work, dual‐junction with opposite built‐in electric fields using...
A tissue-mimicking material (TMM) for the acoustic and thermal characterization of high-intensity focused ultrasound (HIFU) devices has been developed. The is a high-temperature hydrogel matrix (gellan gum) combined with different sizes aluminum oxide particles other chemicals. ultrasonic properties (attenuation coefficient, speed sound, acoustical impedance, conductivity diffusivity) were characterized as function temperature from 20 to 70°C. backscatter coefficient nonlinearity parameter...
Purpose: To study how pressure pulses affect nerves through mechanisms that are neither thermal nor cavitational, and investigate the effects related to cumulative radiation-force impulse (CRFI). Applications include traumatic brain injury acoustic neuromodulation. Methods: A simple neural model consisting of giant axon a live earthworm was exposed trains produced by an 825 kHz focused ultrasound transducer. The peak negative duty cycle pulse train were controlled so cavitation significant...
Nonlinear acoustic signals contain significant energy at many harmonic frequencies. For applications, the sensitivity (frequency response) of a hydrophone will not be uniform over such broad spectrum. In continuation previous investigation involving deconvolution methodology, (implemented in frequency domain as an inverse filter computed from frequency-dependent sensitivity) was investigated for improvement accuracy and precision nonlinear output measurements. Timedelay spectrometry used to...
A method based on time-delay spectrometry (TDS) was developed for measuring both magnitude and phase response of a hydrophone. The tested several types hydrophones used in medical ultrasound exposimetry over the range from 5 to 18 MHz. These included polyvinylidene fluoride (PVDF) spot-poled membrane, needle, capsule designs. One needle hydrophone designed high-intensity focused (HIFU) applications. average reproducibility (after repositioning hydrophone) measurement 2.4°. minimum-phase...