A5035972806- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- Viral Infections and Immunology Research
- Genetic and Kidney Cyst Diseases
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Genetic Mapping and Diversity in Plants and Animals
- Genetic diversity and population structure
- Genetic and phenotypic traits in livestock
University of Washington
2024-2025
Yangzhou University
2004
Abstract Dipeptidyl peptidase-4 (DPP4) is a well-established receptor for several MERS-related coronaviruses (MERSr-CoVs) isolated from humans, camels, pangolins, and bats (1–6). However, the usage of many genetically diverse bat MERSr-CoVs with broad geographical distributions remains poorly understood. Recent studies have identified angiotensin-converting enzyme 2 (ACE2) as an entry multiple merbecovirus clades. Here, using viral antigen pseudovirus-based functional assays, we demonstrate...
Dipeptidyl peptidase-4 (DPP4) is a well-established receptor for several MERS-related coronaviruses (MERSr-CoVs) isolated from humans, camels, pangolins, and bats. However, the usage of many genetically diverse bat MERSr-CoVs with broad geographical distributions remains poorly understood. Recent studies have identified angiotensin-converting enzyme 2 (ACE2) as an entry multiple merbecovirus clades. Here, using viral antigen pseudovirus-based functional assays, we demonstrate that...
Abstract Hedgehog (Hh) signaling relies on the primary cilium, a cell surface organelle that serves as hub for cell. Using proximity labeling and quantitative proteomics, we identify Numb ciliary protein positively regulates Hh signaling. localizes to pocket acts an endocytic adaptor incorporate Ptch1 into clathrin-coated vesicles, thereby promoting exit from key step in activation. loss impedes Sonic hedgehog (Shh)-induced resulting reduced spinal neural progenitors reduces Shh-induced...
SARS-CoV-2 nonstructural protein 1 (nsp1) promotes innate immune evasion by inhibiting host translation in human cells. However, the role of nsp1 other species remains elusive, especially bats which are natural reservoirs sarbecoviruses and possess a markedly different system than humans. Here, we reveal that potently inhibits bat cells from Rhinolophus lepidus, belonging to same genus as known sarbecovirus hosts. We determined cryo-electron microscopy structure bound lepidus 40S ribosome...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 1 (nsp1) promotes innate immune evasion by inhibiting host translation in human cells. However, the role of nsp1 other species remains elusive, especially bats-natural reservoirs sarbecoviruses with a markedly different system than humans. We reveal that potently inhibits Rhinolophus lepidus bat cells, which belong to same genus as known sarbecovirus reservoir hosts. determined cryoelectron microscopy...
A genetic examination using 14 structural loci and 7 microsatellite markers was carried out among random samples of Hu sheep (Hu), Tong (Tong) Yantse River Delta White goat (YRD); The mean heterozygosity (H), polymorphism information contents (PIC) effective numbers alleles (Ne) calculated based on the data from above two types were compared.The standard distances three populations gene frequencies results show that are greater than those loci.The are: 0.0268-0.2487, 0.2321-1.2313.The study...
SUMMARY The transduction of Hedgehog (Hh) signaling relies on the primary cilium, a cell surface organelle serving as hub for cell. Using proximity labeling and quantitative proteomics, we identified Numb new ciliary protein that positively regulates Hh signaling. localizes to pocket acts an endocytic adaptor incorporate Ptch1 into clathrin-coated vesicles, thereby promoting exit from key step in activation. loss hampers Sonic (Shh)-induced departure resulting reduced activation spinal...