A5100442677- Epigenetics and DNA Methylation
- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- Inflammasome and immune disorders
- RNA modifications and cancer
- Allergic Rhinitis and Sensitization
- Peptidase Inhibition and Analysis
- Flavonoids in Medical Research
- HER2/EGFR in Cancer Research
- Inflammatory mediators and NSAID effects
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Dental Health and Care Utilization
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Periodontal Regeneration and Treatments
- Cytokine Signaling Pathways and Interactions
- Pediatric health and respiratory diseases
- Dental Implant Techniques and Outcomes
- Drug Transport and Resistance Mechanisms
- Cancer Immunotherapy and Biomarkers
- High-Temperature Coating Behaviors
- Cancer Genomics and Diagnostics
- Salivary Gland Disorders and Functions
- Ovarian cancer diagnosis and treatment
Third Affiliated Hospital of Zhengzhou University
2025
Affiliated Hospital of Southwest Medical University
2025
Southwest Medical University
2025
Huazhong University of Science and Technology
2006-2025
Maternal and Child Health Hospital of Xinjiang Uygur Autonomous Region
2025
Zhejiang Chinese Medical University
2025
First Affiliated Hospital of Harbin Medical University
2023-2025
Harbin Medical University
2011-2025
Yangzhou University
2025
Union Hospital
2025
To evaluate periodontal conditions in adults mainland China based on data from the 4th National Oral Health Survey.Data of adult subjects (35- to 44-year-old group [N = 4409], 55- 64-year-old 4622], and 65- 74-year-old 4428]) were analysed. Demographic, socio-economic, personal habit, dental history, health attitude obtained using a questionnaire. Periodontal condition was assessed standardized case definitions 2018 classification scheme. A multivariate analysis performed investigate...
Multifunctional hydrogels with controllable degradation and drug release have attracted extensive attention in diabetic wound healing. This study focused on the acceleration of healing selenide-linked polydopamine-reinforced hybrid on-demand light-triggered nanozyme release.Herein, selenium-containing hydrogels, defined as DSeP@PB, were fabricated via reinforcement selenol-end capping polyethylene glycol (PEG) by polydopamine nanoparticles (PDANPs) Prussian blue nanozymes a one-pot approach...
Chemoresistance is a formidable issue in clinical anticancer therapy and pertinent to the lowered efficacies of chemotherapeutics activated tumor self-repairing proceedings. Herein, bifunctional amphiphiles containing galactose ligands high-density disulfide are synthesized for encapsulating mitochondrion-targeting tetravalent platinum prodrugs construct cascade targeted mitochondrion-dysfunctional nanomedicine (Gal-NP@TPt). Subsequent investigations verify that Gal-NP@TPt with sequential...
Abstract Purpose: A major challenge in platinum-based cancer therapy is the clinical management of chemoresistant tumors, which have a largely unknown pathogenesis at level epigenetic regulation. Experimental Design: We evaluated potential using global loss 5-hydroxymethylcytosine (5-hmC) levels as novel diagnostic and prognostic marker to better assess chemotherapy response outcome high-grade serous tumors (HGSOC), most common deadliest subtype ovarian cancer. Furthermore, we identified...
Aims . The aim of this study was to investigate whether resveratrol (RSV) could ameliorate ischemia- and hypoxia-associated cardiomyocyte apoptosis injury via inhibiting senescence signaling inflammasome activation. Materials Methods Mice were treated with RSV by gastric tube (320 mg/kg/day) or vehicle one week before left coronary artery ligation sham surgery until the end experiments. After pressure–volume loop analysis, mouse hearts harvested for histopathological (including PSR, TTC,...
Abstract Aim To investigate the effects of sodium butyrate (NaB) and lipopolysaccharide (LPS) on gingival epithelial barrier. Material methods We cultured human primary cells investigated NaB LPS barrier involved mechanisms at in vitro vivo levels by immunostaining, confocal microscopy, field emission scanning electron microscopy (FE‐SEM), transmission electronic (TEM), transepithelial electrical resistance (TEER), FTIC‐dextran flux, flow cytometry, real‐time PCR Western blot assays. Results...
Background Allergen immunotherapy (AIT) can induce immune tolerance to allergens by activating multiple mechanisms, including promoting IgG4 synthesis and blunting IgE production. However, the longitudinal data of sIgE sIgG4 allergen components during AIT are limited. Objective We sought investigate persistence evolution against house dust mite (HDM) explore their correlation with clinical responses. Methods Sixty allergic rhinitis (AR) with/without asthma patients receiving for HDM were...
This study sought to investigate associations of 25-hydroxyvitamin D (25(OH)D) metabolites with periodontitis and assess causality using Mendelian randomization (MR).This included 7246 participants the National Health Nutrition Examination Survey, 2009-2012. The association 25(OH)D was assessed multivariable logistic regression analysis. Two-sample MR for 25(OH)D, 25(OH)D3 , C3-epi-25(OH)D3 (n = 17,353 cases/28,210 controls) conducted. principal analysis employed inverse-variance-weighted...
Intracellular tau aggregates composed of neurofibrillary tangles (NFTs) are a defining feature Alzheimer's disease (AD). Increased expression heme oxygenase-1 (HO-1) is common phenomenon in AD. Interestingly, the spatial distribution HO-1 essentially identical to that pathological accumulation In this study, we developed new transgenic mouse overexpressing HO-1, called CAG-HO-1 Tg mice, explore relationship between and aggregation. model, found long-term overexpression significantly promoted...
Abstract Objective Idiopathic infantile hypercalcemia (IIH) is a rare disorder of PTH-independent hypercalcemia. CYP24A1 and SLC34A1 gene mutations cause two forms hereditary IIH. In this study, the clinical manifestations molecular aspects six new Chinese patients were investigated. Methods The laboratory study with idiopathic analyzed retrospectively. Results Five diagnosed hypercalcemia, hypercalciuria, bilateral medullary nephrocalcinosis. Their symptoms biochemical abnormalities...
Salidroside (SAL) is a phenylethanoid glycoside isolated from the medicinal plant Rhodiola rosea. R. rosea has been reported to have beneficial effects on diabetic nephropathy (DN) and high-glucose (HG)-induced mesangial cell proliferation. Given importance of caveolin-1 (Cav-1) in transcytosis albumin across endothelial barrier, present study was designed elucidate whether SAL could inhibit Cav-1 phosphorylation reduce glomerular cells (GECs) alleviate albuminuria as well explore its...
Abstract Aim The rising prevalence of periodontitis imposes substantial burdens on individuals and society. Identifying environmental risk factors for may contribute to tackling the global public health burden it. This study aimed assess association between long‐term exposure PM 2.5 in a nationally representative population from China. Materials Methods In this multi‐centre cross‐sectional 372 communities 31 provinces Mainland China, we used data Fourth National Oral Health Survey China...